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Pickering emulsion droplet-based biomimetic microreactors for continuous flow cascade reactions

Zhang, Ming; Ettelaie, Rammile; Dong, Lianlian; Li, Xiaolong; Li, Ting; Zhang, Xiaoming; Binks, Bernard P.; Yang, Hengquan

Authors

Ming Zhang

Rammile Ettelaie

Lianlian Dong

Xiaolong Li

Ting Li

Xiaoming Zhang

Hengquan Yang



Abstract

A continuous flow cascade of multi-step catalytic reactions is a cutting-edge concept to revolutionize stepwise catalytic synthesis yet is still challenging in practical applications. Herein, a method for practical one-pot cascade catalysis is developed by combining Pickering emulsions with continuous flow. Our method involves co-localization of different catalytically active sub-compartments within droplets of a Pickering emulsion yielding cell-like microreactors, which can be packed in a column reactor for continuous flow cascade catalysis. As exemplified by two chemo-enzymatic cascade reactions for the synthesis of chiral cyanohydrins and chiral ester, 5 − 420 fold enhancement in the catalysis efficiency and as high as 99% enantioselectivity were obtained even over a period of 80 − 240 h. The compartmentalization effect and enriching-reactant properties arising from the biomimetic microreactor are theoretically and experimentally identified as the key factors for boosting the catalysis efficiency and for regulating the kinetics of cascade catalysis.

Citation

Zhang, M., Ettelaie, R., Dong, L., Li, X., Li, T., Zhang, X., Binks, B. P., & Yang, H. (2022). Pickering emulsion droplet-based biomimetic microreactors for continuous flow cascade reactions. Nature communications, 13, Article 475. https://doi.org/10.1038/s41467-022-28100-6

Journal Article Type Article
Acceptance Date Jan 4, 2022
Online Publication Date Jan 25, 2022
Publication Date Dec 1, 2022
Deposit Date Jun 5, 2023
Publicly Available Date Jun 9, 2023
Journal Nature Communications
Electronic ISSN 2041-1723
Publisher Nature Publishing Group
Peer Reviewed Peer Reviewed
Volume 13
Article Number 475
DOI https://doi.org/10.1038/s41467-022-28100-6
Keywords Catalyst synthesis; Heterogeneous catalysis
Public URL https://hull-repository.worktribe.com/output/3921235

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http://creativecommons.org/licenses/by/4.0

Copyright Statement
© The Author(s) 2022.
Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.





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