Mohan Prasath Mani
Grapefruit Oil and Cobalt Nitrate-Loaded Polyurethane Hybrid Nanofibrous Scaffold for Biomedical Applications
Mani, Mohan Prasath; Mohd Faudzi, Ahmad Athif; Mohamaddan, Shahrol; Ismail, Ahmad Fauzi; Rathanasamy, Rajasekar; Ayyar, Manikandan; Jaganathan, Saravana Kumar
Authors
Ahmad Athif Mohd Faudzi
Shahrol Mohamaddan
Ahmad Fauzi Ismail
Rajasekar Rathanasamy
Manikandan Ayyar
Saravana Kumar Jaganathan
Abstract
The goal of this work is to fabricate a new composite based on polyurethane (PU), grapefruit (GP) oil, and cobalt nitrate [Co(NO3)2] using an electrospinning technique. Morphology results revealed the reduction in the fiber diameter of the composites compared to pristine PU control. The interaction of PU with GP and Co(NO3)2 was confirmed by hydrogen bond formation evident in infrared analysis. The fabricated PU/GP composites depicted a more hydrophobic behavior, while PU/GP/Co(NO3)2 showed a hydrophilic behavior than the pristine PU. Atomic force micrographs (AFM) revealed that the developed composites showed a decrease in the surface roughness (Ra) compared to PU. The addition of GP and Co(NO3)2 improved the mechanical strength of the pristine PU. The blood compatibility assays concluded not only the increase in blood clotting levels but also the less toxic nature of the fabricated composites compared to the pristine PU. Hence, the newly designed composites possessing outstanding physicochemical and biological properties may be used as a potential candidate for scaffolding in tissue engineering applications.
Citation
Mani, M. P., Mohd Faudzi, A. A., Mohamaddan, S., Ismail, A. F., Rathanasamy, R., Ayyar, M., & Jaganathan, S. K. (2022). Grapefruit Oil and Cobalt Nitrate-Loaded Polyurethane Hybrid Nanofibrous Scaffold for Biomedical Applications. Frontiers in Materials, 9, Article 827009. https://doi.org/10.3389/fmats.2022.827009
| Journal Article Type | Article |
|---|---|
| Acceptance Date | Jan 25, 2022 |
| Online Publication Date | Mar 9, 2022 |
| Publication Date | Mar 9, 2022 |
| Deposit Date | Apr 28, 2022 |
| Publicly Available Date | May 3, 2022 |
| Journal | Frontiers in Materials |
| Electronic ISSN | 2296-8016 |
| Publisher | Frontiers Media |
| Peer Reviewed | Peer Reviewed |
| Volume | 9 |
| Article Number | 827009 |
| DOI | https://doi.org/10.3389/fmats.2022.827009 |
| Keywords | PU; Co(NO3)2; Grapefruit oil; Electrospun scaffold; Tissue engineering |
| Public URL | https://hull-repository.worktribe.com/output/3970988 |
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http://creativecommons.org/licenses/by/4.0
Copyright Statement
Copyright © 2022 Mani, Mohd Faudzi, Mohamaddan, Ismail, Rathanasamy, Ayyar and Jaganathan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.