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Grapefruit Oil and Cobalt Nitrate-Loaded Polyurethane Hybrid Nanofibrous Scaffold for Biomedical Applications

Mani, Mohan Prasath; Mohd Faudzi, Ahmad Athif; Mohamaddan, Shahrol; Ismail, Ahmad Fauzi; Rathanasamy, Rajasekar; Ayyar, Manikandan; Jaganathan, Saravana Kumar


Mohan Prasath Mani

Ahmad Athif Mohd Faudzi

Shahrol Mohamaddan

Ahmad Fauzi Ismail

Rajasekar Rathanasamy

Manikandan Ayyar

Saravana Kumar Jaganathan


The goal of this work is to fabricate a new composite based on polyurethane (PU), grapefruit (GP) oil, and cobalt nitrate [Co(NO3)2] using an electrospinning technique. Morphology results revealed the reduction in the fiber diameter of the composites compared to pristine PU control. The interaction of PU with GP and Co(NO3)2 was confirmed by hydrogen bond formation evident in infrared analysis. The fabricated PU/GP composites depicted a more hydrophobic behavior, while PU/GP/Co(NO3)2 showed a hydrophilic behavior than the pristine PU. Atomic force micrographs (AFM) revealed that the developed composites showed a decrease in the surface roughness (Ra) compared to PU. The addition of GP and Co(NO3)2 improved the mechanical strength of the pristine PU. The blood compatibility assays concluded not only the increase in blood clotting levels but also the less toxic nature of the fabricated composites compared to the pristine PU. Hence, the newly designed composites possessing outstanding physicochemical and biological properties may be used as a potential candidate for scaffolding in tissue engineering applications.


Mani, M. P., Mohd Faudzi, A. A., Mohamaddan, S., Ismail, A. F., Rathanasamy, R., Ayyar, M., & Jaganathan, S. K. (2022). Grapefruit Oil and Cobalt Nitrate-Loaded Polyurethane Hybrid Nanofibrous Scaffold for Biomedical Applications. Frontiers in Materials, 9, Article 827009.

Journal Article Type Article
Acceptance Date Jan 25, 2022
Online Publication Date Mar 9, 2022
Publication Date Mar 9, 2022
Deposit Date Apr 28, 2022
Publicly Available Date May 3, 2022
Journal Frontiers in Materials
Electronic ISSN 2296-8016
Publisher Frontiers Media
Peer Reviewed Peer Reviewed
Volume 9
Article Number 827009
Keywords PU; Co(NO3)2; Grapefruit oil; Electrospun scaffold; Tissue engineering
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Copyright Statement
Copyright © 2022 Mani, Mohd Faudzi, Mohamaddan, Ismail, Rathanasamy, Ayyar and Jaganathan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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