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Development and blood compatibility evaluation of novel fibrous textile scaffold based on polyurethane amalgamated with Alternanthera sessilis oil for the bone tissue engineering

Jaganathan, Saravana Kumar

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Abstract

In the recent decade, the growth of medical textiles is enormous and it paves the sustained development in the quality of life. In this research, an electrospun textile scaffold comprising polyurethane impregnated with Alternanthera sessilis oil was developed for the bone tissue engineering. Morphology analysis showed that the addition of Alternanthera sessilis oil in the polyurethane membrane resulted in reduced fiber diameter (821 ± 140.87 nm) compared to the pristine PU (890 ± 119.11 nm). The presence of Alternanthera sessilis oil in polyurethane membrane was confirmed through hydrogen bond formation as revealed in the infrared analysis. Further, the polyurethane blended with Alternanthera sessilis oil showed hydrophobic (113.7° ± 3.215) and improved surface roughness (329 nm) than the pristine polyurethane (contact angle – 100° ± 0.5774 and Ra – 313 nm). Moreover, the blood compatibility assessments revealed that the developed biocomponent polyurethane/Alternanthera sessilis oil membrane possesses enhanced anticoagulant nature compared to the pristine polyurethane. Finally, the newly developed biocomponent polyurethane/Alternanthera sessilis oil membrane with reduced fiber diameter, hydrophobic behavior, improved surface roughness, and enhanced blood compatibility enabled them as a potential candidate for bone tissue regeneration.

Journal Article Type Article
Journal Journal of Industrial Textiles
Print ISSN 1528-0837
Electronic ISSN 1530-8057
Publisher SAGE Publications
Peer Reviewed Peer Reviewed
Article Number 152808372090680
APA6 Citation Jaganathan, S. K., & Mani, M. P. (in press). Development and blood compatibility evaluation of novel fibrous textile scaffold based on polyurethane amalgamated with Alternanthera sessilis oil for the bone tissue engineering. Journal of Industrial Textiles, https://doi.org/10.1177/1528083720906809
DOI https://doi.org/10.1177/1528083720906809
Keywords Polyurethane; Alternanthera sessilis; Fibrous textile scaffold; Bone tissue engineering
Publisher URL https://journals.sagepub.com/doi/10.1177/1528083720906809

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