Wound complications following surgery to the lymph nodes: A protocol for a systematic review and meta-analysis

Nzenwa, Ikemsinachi C.; Iqbal, Hassan A.; Hardie, Claire; Smith, George E.; Matteucci, Paolo L.; Totty, Joshua P.

Abstract

Background Malignancies that spread to the lymph nodes may be identified through surgical biopsy, and treatment of metastatic disease may be through lymph node dissection. These surgeries, however, may be associated with significant adverse outcomes, particularly wound complications, the true incidence of which remains unknown. Multiple studies have reported their individual rates of complications in isolation. The aim of this study will be to systematically evaluate data that presents the incidence of wound complications in patients undergoing these surgeries. Methods We have designed and registered a protocol for a systematic review and meta-analysis of studies presenting incidence data. We will search MEDLINE, EMBASE and CENTRAL for relevant articles. Meta-analysis will be undertaken to synthesise an overall incidence of surgical site infection, wound dehiscence, haematoma and seroma. Subgroup analyses will investigate the effects of anatomical location, primary malignancy and study design on pooled incidence. Risk of bias will be evaluated for each included study using bespoke tools matched to the study design. Discussion The results of this study will provide the incidence of wound complications and secondary complications following lymph node surgery. This will directly impact upon the consent process, and may influence the nature of future research studies aimed at reducing post-operative complications.

Citation

Nzenwa, I. C., Iqbal, H. A., Hardie, C., Smith, G. E., Matteucci, P. L., & Totty, J. P. (2022). Wound complications following surgery to the lymph nodes: A protocol for a systematic review and meta-analysis. PLoS ONE, 17(8), Article e0272490. https://doi.org/10.1371/journal.pone.0272490

• Journal Article Type: Review
• Acceptance Date: Jul 12, 2022
• Online Publication Date: Aug 3, 2022
• Publication Date: Aug 1, 2022
• Deposit Date: Aug 4, 2022
• Publicly Available Date: Aug 4, 2022
• Journal: PLoS ONE
• Print ISSN: 1932-6203
• Publisher: Public Library of Science
• Peer Reviewed: Peer Reviewed
• Volume: 17
• Issue: 8
• Article Number: e0272490
• DOI: https://doi.org/10.1371/journal.pone.0272490
• Keywords: Multidisciplinary
• Public URL: https://hull-repository.worktribe.com/output/4044745