A set of highly water-soluble tetraethyleneglycol-substituted Zn(ii) phthalocyanines: synthesis, photochemical and photophysical properties, interaction with plasma proteins and in vitro phototoxicity

Gailer, Juergen; Durmus, Mahmut; Tuncel, Sinem; Dumoulin, Fabienne; Gailer, Jürgen; Sooriyaarachchi, Melani; Atilla, Devrim; Durmu?, Mahmut; Bouchu, Denis; Savoie, Huguette; Boyle, Ross W.; Ahsen, Vefa

Abstract

Three Zn(II) phthalocyanines substituted by hydroxyl-terminated tetraethylene glycol chains have been synthesized. In order to evaluate the potential of these highly water-soluble phthalocyanines as type II-photosensitisers for photodynamic therapy, their structure-activity relationship was assessed by determining relevant photophysical and photochemical properties, such as their aggregation behaviour in aqueous buffers, their fluorescence properties and their efficiency with regard to the generation of singlet oxygen. In addition, evidence for a negligible interaction with plasma proteins in undiluted human plasma was obtained using a recently developed bioanalytical method and compared with the fluorescence quenching approach. These results combined with in vitro data regarding the phototoxicity of these phthalocyanines against HT-29 cancer cells provide evidence for the relevance of the non-peripherally substituted derivative for further in vivo investigations.

Citation

Tuncel, S., Dumoulin, F., Gailer, J., Sooriyaarachchi, M., Atilla, D., Durmuş, M., …Ahsen, V. (2011). A set of highly water-soluble tetraethyleneglycol-substituted Zn(ii) phthalocyanines: synthesis, photochemical and photophysical properties, interaction with plasma proteins and in vitro phototoxicity. Dalton Transactions : an international journal of inorganic chemistry, 40(16), 4067-4079. https://doi.org/10.1039/c0dt01260b

• Journal Article Type: Article
• Acceptance Date: Nov 4, 2010
• Online Publication Date: Dec 14, 2010
• Publication Date: Dec 31, 2011
• Journal: DALTON TRANSACTIONS
• Print ISSN: 1477-9226
• Electronic ISSN: 1477-9234
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 40
• Issue: 16
• Pages: 4067-4079
• DOI: https://doi.org/10.1039/c0dt01260b
• Keywords: Inorganic Chemistry
• Public URL: https://hull-repository.worktribe.com/output/405280