Yuan Li
Assessment of mitochondrial dysfunction and implications in cardiovascular disorders
Li, Yuan; Ma, Ying; Dang, Qing Ya; Fan, Xin Rong; Han, Chu Ting; Xu, Shang Zhong; Li, Peng Yun
Abstract
Mitochondria play a pivotal role in cellular function, not only acting as the powerhouse of the cell, but also regulating ATP synthesis, reactive oxygen species (ROS) production, intracellular Ca2+ cycling, and apoptosis. During the past decade, extensive progress has been made in the technology to assess mitochondrial functions and accumulating evidences have shown that mitochondrial dysfunction is a key pathophysiological mechanism for many diseases including cardiovascular disorders, such as ischemic heart disease, cardiomyopathy, hypertension, atherosclerosis, and hemorrhagic shock. The advances in methodology have been accelerating our understanding of mitochondrial molecular structure and function, biogenesis and ROS and energy production, which facilitates new drug target identification and therapeutic strategy development for mitochondrial dysfunction-related disorders. This review will focus on the assessment of methodologies currently used for mitochondrial research and discuss their advantages, limitations and the implications of mitochondrial dysfunction in cardiovascular disorders.
Citation
Li, Y., Ma, Y., Dang, Q. Y., Fan, X. R., Han, C. T., Xu, S. Z., & Li, P. Y. (2022). Assessment of mitochondrial dysfunction and implications in cardiovascular disorders. Life Sciences, 306, Article 120834. https://doi.org/10.1016/j.lfs.2022.120834
Journal Article Type | Review |
---|---|
Acceptance Date | Jul 20, 2022 |
Online Publication Date | Jul 25, 2022 |
Publication Date | Oct 1, 2022 |
Deposit Date | Aug 30, 2022 |
Publicly Available Date | Jan 31, 2024 |
Journal | Life Sciences |
Print ISSN | 0024-3205 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 306 |
Article Number | 120834 |
DOI | https://doi.org/10.1016/j.lfs.2022.120834 |
Keywords | Mitochondrial dysfunction; Mitochondrial dynamics; Oxidative stress; Mitochondrial energy metabolism; Ca2+ signaling; Mitochondrial permeability transition pore |
Public URL | https://hull-repository.worktribe.com/output/4063165 |
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https://creativecommons.org/licenses/by-nc-nd/4.0/
Copyright Statement
© 2022. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
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