Effect of terbutaline on hyperpnoea-induced bronchoconstriction and urinary club cell protein 16 in athletes

Simpson, A. J.; Simpson, A. J.; Tufvesson, E.; Tufvesson, E.; Anderson, S. D.; Anderson, S. D.; Romer, L. M.; Romer, L. M.; Bjermer, L.; Bjermer, L.; Kippelen, P.; Kippelen, P.

Abstract

Repeated injury of the airway epithelium caused by hyperpnoea of poorly conditioned air has been proposed as a key factor in the pathogenesis of exercise-induced bronchoconstriction (EIB) in athletes. In animals, the short-acting β2-agonist terbutaline has been shown to reduce dry airflow-induced bronchoconstriction and the associated shedding of airway epithelial cells. Our aim was to test the efficacy of inhaled terbutaline in attenuating hyperpnoea-induced bronchoconstriction and airway epithelial injury in athletes. Twenty-seven athletes with EIB participated in a randomized, double-blind, placebo-controlled, crossover study. Athletes completed an 8-min eucapnic voluntary hyperpnoea (EVH) test with dry air on two separate days 15 min after inhaling 0.5 mg terbutaline or a matching placebo. Forced expiratory volume in 1 s (FEV1) and urinary concentration of the club cell (Clara cell) protein 16 (CC16, a marker of airway epithelial perturbation) were measured before and up to 60 min after EVH. The maximum fall in FEV1 of 17 ± 8% (SD) on placebo was reduced to 8 ± 5% following terbutaline (P < 0.001). Terbutaline gave bronchoprotection (i.e., post-EVH FEV1 fall

Citation

Simpson, A. J., Simpson, A. J., Tufvesson, E., Tufvesson, E., Anderson, S. D., Anderson, S. D., …Kippelen, P. (2013). Effect of terbutaline on hyperpnoea-induced bronchoconstriction and urinary club cell protein 16 in athletes. Journal of Applied Physiology, 115(10), 1450-1456. https://doi.org/10.1152/japplphysiol.00716.2013

• Acceptance Date: Sep 4, 2013
• Online Publication Date: Sep 12, 2013
• Publication Date: Nov 15, 2013
• Deposit Date: Nov 23, 2017
• Publicly Available Date: Jan 19, 2018
• Journal: Journal of Applied Physiology
• Print ISSN: 8750-7587
• Electronic ISSN: 1522-1601
• Publisher: American Physiological Society
• Peer Reviewed: Peer Reviewed
• Volume: 115
• Issue: 10
• Pages: 1450-1456
• DOI: https://doi.org/10.1152/japplphysiol.00716.2013
• Keywords: Physiology (medical); Physiology; exercise-induced bronchoconstriction; epithelial injury; Clara cell
• Public URL: https://hull-repository.worktribe.com/output/426258
• Publisher URL: http://www.physiology.org/doi/abs/10.1152/japplphysiol.00716.2013
• Related Public URLs: http://bura.brunel.ac.uk/handle/2438/8432