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Effect of terbutaline on hyperpnoea-induced bronchoconstriction and urinary club cell protein 16 in athletes

Simpson, A. J.; Simpson, A. J.; Tufvesson, E.; Tufvesson, E.; Anderson, S. D.; Anderson, S. D.; Romer, L. M.; Romer, L. M.; Bjermer, L.; Bjermer, L.; Kippelen, P.; Kippelen, P.

Authors

E. Tufvesson

E. Tufvesson

S. D. Anderson

S. D. Anderson

L. M. Romer

L. M. Romer

L. Bjermer

L. Bjermer

P. Kippelen

P. Kippelen



Abstract

Repeated injury of the airway epithelium caused by hyperpnoea of poorly conditioned air has been proposed as a key factor in the pathogenesis of exercise-induced bronchoconstriction (EIB) in athletes. In animals, the short-acting β2-agonist terbutaline has been shown to reduce dry airflow-induced bronchoconstriction and the associated shedding of airway epithelial cells. Our aim was to test the efficacy of inhaled terbutaline in attenuating hyperpnoea-induced bronchoconstriction and airway epithelial injury in athletes. Twenty-seven athletes with EIB participated in a randomized, double-blind, placebo-controlled, crossover study. Athletes completed an 8-min eucapnic voluntary hyperpnoea (EVH) test with dry air on two separate days 15 min after inhaling 0.5 mg terbutaline or a matching placebo. Forced expiratory volume in 1 s (FEV1) and urinary concentration of the club cell (Clara cell) protein 16 (CC16, a marker of airway epithelial perturbation) were measured before and up to 60 min after EVH. The maximum fall in FEV1 of 17 ± 8% (SD) on placebo was reduced to 8 ± 5% following terbutaline (P < 0.001). Terbutaline gave bronchoprotection (i.e., post-EVH FEV1 fall

Publication Date Nov 15, 2013
Journal Journal of Applied Physiology
Print ISSN 8750-7587
Electronic ISSN 1522-1601
Publisher American Physiological Society
Peer Reviewed Peer Reviewed
Volume 115
Issue 10
Pages 1450-1456
APA6 Citation Simpson, A. J., Simpson, A. J., Tufvesson, E., Tufvesson, E., Anderson, S. D., Anderson, S. D., …Kippelen, P. (2013). Effect of terbutaline on hyperpnoea-induced bronchoconstriction and urinary club cell protein 16 in athletes. Journal of Applied Physiology, 115(10), 1450-1456. https://doi.org/10.1152/japplphysiol.00716.2013
DOI https://doi.org/10.1152/japplphysiol.00716.2013
Keywords Physiology (medical); Physiology; exercise-induced bronchoconstriction; epithelial injury; Clara cell
Publisher URL http://www.physiology.org/doi/abs/10.1152/japplphysiol.00716.2013
Related Public URLs http://bura.brunel.ac.uk/handle/2438/8432
Copyright Statement This article is made available through the Brunel Open Access Publishing Fund and is distributed by the Creative Commons CC-BY 3.0 license, under which all are free to reuse or distribute the article under the condition that this original publication must be cited.

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Copyright Statement
This article is made available through the Brunel Open Access Publishing Fund and is distributed by the Creative Commons CC-BY 3.0 license, under which all are free to reuse or distribute the article under the condition that this original publication must be cited.



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