Effect of terbutaline on hyperpnoea-induced bronchoconstriction and urinary club cell protein 16 in athletes

Simpson, A. J.; Simpson, A. J.; Tufvesson, E.; Tufvesson, E.; Anderson, S. D.; Anderson, S. D.; Romer, L. M.; Romer, L. M.; Bjermer, L.; Bjermer, L.; Kippelen, P.; Kippelen, P.

Abstract

Repeated injury of the airway epithelium caused by hyperpnoea of poorly conditioned air has been proposed as a key factor in the pathogenesis of exercise-induced bronchoconstriction (EIB) in athletes. In animals, the short-acting β2-agonist terbutaline has been shown to reduce dry airflow-induced bronchoconstriction and the associated shedding of airway epithelial cells. Our aim was to test the efficacy of inhaled terbutaline in attenuating hyperpnoea-induced bronchoconstriction and airway epithelial injury in athletes. Twenty-seven athletes with EIB participated in a randomized, double-blind, placebo-controlled, crossover study. Athletes completed an 8-min eucapnic voluntary hyperpnoea (EVH) test with dry air on two separate days 15 min after inhaling 0.5 mg terbutaline or a matching placebo. Forced expiratory volume in 1 s (FEV1) and urinary concentration of the club cell (Clara cell) protein 16 (CC16, a marker of airway epithelial perturbation) were measured before and up to 60 min after EVH. The maximum fall in FEV1 of 17 ± 8% (SD) on placebo was reduced to 8 ± 5% following terbutaline (P < 0.001). Terbutaline gave bronchoprotection (i.e., post-EVH FEV1 fall

Citation

Simpson, A. J., Simpson, A. J., Tufvesson, E., Tufvesson, E., Anderson, S. D., Anderson, S. D., Romer, L. M., Romer, L. M., Bjermer, L., Bjermer, L., Kippelen, P., & Kippelen, P. (2013). Effect of terbutaline on hyperpnoea-induced bronchoconstriction and urinary club cell protein 16 in athletes. Journal of Applied Physiology, 115(10), 1450-1456. https://doi.org/10.1152/japplphysiol.00716.2013

• Acceptance Date: Sep 4, 2013
• Online Publication Date: Sep 12, 2013
• Publication Date: Nov 15, 2013
• Deposit Date: Nov 23, 2017
• Publicly Available Date: Jan 19, 2018
• Journal: Journal of Applied Physiology
• Print ISSN: 8750-7587
• Publisher: American Physiological Society
• Peer Reviewed: Peer Reviewed
• Volume: 115
• Issue: 10
• Pages: 1450-1456
• DOI: https://doi.org/10.1152/japplphysiol.00716.2013
• Keywords: Physiology (medical); Physiology; exercise-induced bronchoconstriction; epithelial injury; Clara cell
• Public URL: https://hull-repository.worktribe.com/output/426258
• Publisher URL: http://www.physiology.org/doi/abs/10.1152/japplphysiol.00716.2013
• Related Public URLs: http://bura.brunel.ac.uk/handle/2438/8432
• Contract Date: Dec 19, 2017