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Fabrication of Poly(ε-caprolactone)-embedded Lignin-Chitosan Nanocomposite Porous Scaffolds from Pickering Emulsions

Li, Yaozong; Peng, Yingying; Hu, Yang; Liu, Jian; Yuan, Teng; Zhou, Wuyi; Dong, Xianming; Wang, Chaoyang; Binks, Bernard P.; Yang, Zhuohong


Yaozong Li

Yingying Peng

Yang Hu

Jian Liu

Teng Yuan

Wuyi Zhou

Xianming Dong

Chaoyang Wang

Zhuohong Yang


Poly(ε-caprolactone) (PCL)-incorporated lignin-chitosan biomass-based nanocomposite porous scaffolds have been effectively prepared by templating oil-in-water Pickering high internal phase emulsions (HIPEs). PCL is dissolved in oil and chitosan and lignin nanoparticles originate in water. The continuous phase of the emulsions is gelled by cross-linking of chitosan with genipin and then freeze-dried to obtain porous scaffolds. The resulting scaffolds display interconnected and tunable pore structures. An increase in PCL content increases the mechanical strength and greatly reduces the water absorption capacity of the scaffolds. Scaffolds loaded with the anti-bacterial drug enrofloxacin show a slow drug release profile, adjustable release rate, and favorable long-term anti-bacterial activity. Moreover, Pickering emulsion templates with suitable viscosity are used as 3D printing inks to construct porous scaffolds with personalized geometry. The results imply that the simplicity and versatility of the technique of combining freeze-drying with Pickering HIPE templates is a promising approach to fabricate hydrophobic biopolymer-incorporated biomass-based nanocomposite porous scaffolds for biomedical applications.


Li, Y., Peng, Y., Hu, Y., Liu, J., Yuan, T., Zhou, W., …Yang, Z. (2023). Fabrication of Poly(ε-caprolactone)-embedded Lignin-Chitosan Nanocomposite Porous Scaffolds from Pickering Emulsions. Langmuir : the ACS journal of surfaces and colloids, 39(20), 6947-6956.

Journal Article Type Article
Acceptance Date Apr 24, 2023
Online Publication Date May 12, 2023
Publication Date May 23, 2023
Deposit Date Jun 3, 2023
Publicly Available Date May 13, 2024
Journal Langmuir : the ACS journal of surfaces and colloids
Print ISSN 0743-7463
Electronic ISSN 1520-5827
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 39
Issue 20
Pages 6947-6956
Public URL


Accepted manuscript (15 Mb)

Copyright Statement
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Langmuir, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see

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