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Recurring patterns of atrial fibrillation in surface ECG predict restoration of sinus rhythm by catheter ablation

Di Marco, Luigi Yuri; Raine, Daniel; Bourke, John P.; Langley, Philip

Authors

Luigi Yuri Di Marco

Daniel Raine

John P. Bourke



Abstract

Background Non-invasive tools to help identify patients likely to benefit from catheter ablation (CA) of atrial fibrillation (AF) would facilitate personalised treatment planning. Aim To investigate atrial waveform organisation through recurrence plot indices (RPI) and their ability to predict CA outcome. Methods One minute 12-lead ECG was recorded before CA from 62 patients with AF (32 paroxysmal AF; 45 men; age 57±10 years). Organisation of atrial waveforms from i) TQ intervals in V1 and ii) QRST suppressed continuous AF waveforms (CAFW), were quantified using RPI: percentage recurrence (PR), percentage determinism (PD), entropy of recurrence (ER). Ability to predict acute (terminating vs. non-terminating AF), 3-month and 6-month postoperative outcome (AF vs. AF free) were assessed. Results RPI either by TQ or CAFW analysis did not change significantly with acute outcome. Patients arrhythmia-free at 6-month follow-up had higher organisation in TQ intervals by PD (p<0.05) and ER (p<0.005) and both were significant predictors of 6-month outcome (PD (AUC=0.67, p<0.05) and ER (AUC=0.72, p<0.005)). For paroxysmal AF cases, all RPI predicted 3-month (AUC(ER)=0.78, p<0.05; AUC(PD)=0.79, p<0.05; AUC(PR)=0.80, p<0.01) and 6-month (AUC(ER)=0.81, p<0.005; AUC(PD)=0.75, p<0.05; AUC(PR)=0.71, p<0.05) outcome. CAFW-derived RPIs did not predict acute or postoperative outcomes. Higher values of any RPI from TQ (values greater than 25th percentile of preoperative distribution) were associated with decreased risk of AF relapse at follow-up (hazard ratio ≤0.52, all p<0.05). Conclusions Recurring patterns from preprocedural 1-minute recordings of ECG TQ intervals were significant predictors of CA 6-month outcome.

Journal Article Type Article
Publication Date Nov 1, 2014
Journal Computers in biology and medicine
Print ISSN 0010-4825
Electronic ISSN 1879-0534
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 54
Pages 172-179
APA6 Citation Di Marco, L. Y., Raine, D., Bourke, J. P., & Langley, P. (2014). Recurring patterns of atrial fibrillation in surface ECG predict restoration of sinus rhythm by catheter ablation. Computers in biology and medicine, 54, 172-179. https://doi.org/10.1016/j.compbiomed.2014.09.005
DOI https://doi.org/10.1016/j.compbiomed.2014.09.005
Keywords Atrial fibrillation; TQ interval; Recurrence quantification analysis; Principal component analysis; Electrocardiogram segmentation
Publisher URL http://www.sciencedirect.com/science/article/pii/S001048251400256X
Additional Information This is an accepted version of an article published in Computers in biology and medicine, 2014, v.54.

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Copyright Statement
©2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/





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