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Validation of an algorithm to reveal the U wave in atrial fibrillation

Al-Karadi, M. S.; Wilkinson, A. J.; Caldwell, J.; Langley, P.

Authors

M. S. Al-Karadi

A. J. Wilkinson

J. Caldwell



Abstract

Major cardiac organisations recommend U wave abnormalities should be reported during ECG interpretation. However, U waves cannot be measured in patients with atrial fibrillation (AF) due to the obscuring fibrillatory wave. The aim was to validate a U wave measurement algorithm for AF patients. Multi-beat averaging was applied to ECGs of 25 patients during paroxysms of AF and the presence of U waves compared to those from the same patients during sinus rhythm (SR). In a further database of 10 long-term AF recordings, the number of beats for effective U wave extraction by the algorithm was calculated. U waves were revealed in all AF recordings and there was no significant difference between the presence of U waves in AF and SR (p = 0.88). U wave amplitude was significantly increased in AF (mean (s.d.) amplitude 55 (39) AF vs 37 (28) μV SR, p = 0.005). The presence of U waves could easily be discerned when as few as 10 beats were used in the algorithm. The study demonstrates the validity of the algorithm to reveal U waves in AF recordings. The algorithm offers the potential to detect U wave abnormalities in patients with AF.

Journal Article Type Article
Publication Date Aug 9, 2018
Journal Scientific Reports
Print ISSN 2045-2322
Publisher Nature Publishing Group
Peer Reviewed Peer Reviewed
Volume 8
Issue 1
Article Number 11946
Institution Citation Al-Karadi, M. S., Wilkinson, A. J., Caldwell, J., & Langley, P. (2018). Validation of an algorithm to reveal the U wave in atrial fibrillation. Scientific reports, 8(1), https://doi.org/10.1038/s41598-018-30493-8
DOI https://doi.org/10.1038/s41598-018-30493-8
Keywords Multidisciplinary
Publisher URL https://www.nature.com/articles/s41598-018-30493-8

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