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The benefits of targeted memory reactivation for consolidation in sleep are contingent on memory accuracy and direct cue-memory associations

Cairney, Scott A.; Lindsay, Shane; Sobczak, Justyna M.; Paller, Ken A.; Gaskell, M. Gareth

Authors

Scott A. Cairney

Justyna M. Sobczak

Ken A. Paller

M. Gareth Gaskell

Abstract

Objectives: To investigate how the effects of targeted memory reactivation (TMR) are influenced by memory accuracy prior to sleep and the presence or absence of direct cue-memory associations. Methods: 30 participants associated each of 50 pictures with an unrelated word and then with a screen location in two separate tasks. During picture-location training, each picture was also presented with a semantically related sound. The sounds were therefore directly associated with the picture locations but indirectly associated with the words. During a subsequent nap, half of the sounds were replayed in slow wave sleep (SWS) (TMR). The effect of TMR on memory for the picture locations (direct cue-memory associations) and picture-word pairs (indirect cue-memory associations) was then examined. Results: TMR reduced overall memory decay for recall of picture locations. Further analyses revealed a benefit of TMR for picture locations recalled with a low degree of accuracy prior to sleep, but not those recalled with a high degree of accuracy. The benefit of TMR for low accuracy memories was predicted by time spent in SWS. There was no benefit of TMR for memory of the picture-word pairs, irrespective of memory accuracy prior to sleep. Conclusions: TMR provides the greatest benefit to memories recalled with a low degree of accuracy prior to sleep. The memory benefits of TMR may also be contingent on direct cue-memory associations.

Publication Date May 1, 2016
Journal Sleep
Print ISSN 0161-8105
Electronic ISSN 1550-9109
Publisher Oxford University Press (OUP)
Peer Reviewed Peer Reviewed
Volume 39
Issue 5
Article Number PII sp-00533-15
Pages 1139-1150
Institution Citation Cairney, S. A., Lindsay, S., Sobczak, J. M., Paller, K. A., & Gaskell, M. G. (2016). The benefits of targeted memory reactivation for consolidation in sleep are contingent on memory accuracy and direct cue-memory associations. SLEEP, 39(5), 1139-1150. https://doi.org/10.5665/sleep.5772
DOI https://doi.org/10.5665/sleep.5772
Keywords Consolidation, Memory, Reactivation, Slow wave sleep
Publisher URL http://www.journalsleep.org/ViewAbstract.aspx?pid=30600
Additional Information This is a description of an article which has been published in: Sleep, 2016, v.39, issue 5

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© Copyright 2016 Associated Professional Sleep Societies, LLC



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