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Microbubbles enhanced synthetic phorbol ester degradation by ozonolysis

Kuvshinov, Dmitriy; Siswanto, Anggun; Zimmerman, William

Authors

Dmitriy Kuvshinov

Anggun Siswanto

William Zimmerman



Abstract

A phorbol-12-myristate-13-acetate (TPA) is a synthetic analogue of phorbol ester (PE), a natural toxic compound of Euphorbiaceae plant. The oil extracted from plants of this family is useful source for primarily biofuel. However this oil might also be used as a foodstuff due to its significant nutrition content. The limitations for utilizing the oil as a foodstuff are mainly due to a toxicity of PE. Currently, a majority of PE detoxification processes are expensive as include multi steps alcohol extraction sequence. Ozone is considered as a strong oxidative agent. It reacts with PE by attacking the carbon-carbon double bond of PE. This modification of PE molecular structure yields a non toxic ester with high lipid content. This report presents data on development of simple and cheap PE detoxification process with water application as a buffer and ozone as reactive component. The core of this new technique is an application for a new microscale plasma unit to ozone production and the technology permits ozone injection to the water-TPA mixture in form of microbubbles. The efficacy of a heterogeneous process depends on the diffusion coefficient which can be controlled by contact time and interfacial area. The low velocity of rising microbubbles and high surface to volume ratio allow efficient mass transfer to be achieved during the process. Direct injection of ozone is the most efficient way to process with such highly reactive and short lived chemical. Data on the plasma unit behavior are presented and the influence of gas oscillation technology on the microbubble production mechanism has been discussed. Data on overall process efficacy for TPA degradation is shown.

Citation

Kuvshinov, D., Siswanto, A., & Zimmerman, W. (2014). Microbubbles enhanced synthetic phorbol ester degradation by ozonolysis. International journal of chemical, molecular, nuclear, materials and metallurgical engineering, 8(1), 76-79

Journal Article Type Article
Online Publication Date Apr 1, 2014
Publication Date 2014
Deposit Date Apr 12, 2016
Publicly Available Date Apr 12, 2016
Journal International journal of chemical, molecular, nuclear, materials and metallurgical engineering
Publisher World Academy of Science, Engineering and Technology
Peer Reviewed Peer Reviewed
Volume 8
Issue 1
Pages 76-79
Keywords Microbubble; Ozonolysis; Synthetic phorbol ester
Public URL https://hull-repository.worktribe.com/output/435774
Publisher URL https://panel.waset.org/journal/Chemical/2014/1?new=1
Additional Information Copy of article first published in: International journal of chemical, molecular, nuclear, materials and metallurgical engineering, 2014, v.8, issue 1

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