Malcolm Brown
Feasibility of delivering supervised exercise training following surgical resection and during adjuvant chemotherapy for pancreatic ductal adenocarcinoma (PRECISE): a case series
Brown, Malcolm; O’Connor, Dominic; Turkington, Richard; Eatock, Martin; Vince, Rebecca; Hulme, Claire; Bowdery, Roy; Robinson, Rebecca; Wadsley, Jonathan; Maraveyas, Anthony; Prue, Gillian
Authors
Dominic O’Connor
Richard Turkington
Martin Eatock
Dr Rebecca Vince Rebecca.Vince@hull.ac.uk
Senior Lecturer in Health Physiology
Claire Hulme
Roy Bowdery
Rebecca Robinson
Jonathan Wadsley
Anthony Maraveyas
Gillian Prue
Abstract
Introduction: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive neoplasm, with surgical resection and adjuvant chemotherapy the only curative treatment. Treatment-related toxicities place a considerable burden on patients although exercise training has shown promise is helping to manage such adversities and facilitate rehabilitation. The feasibility and safety of exercise training as a supportive therapy during adjuvant chemotherapy remains unknown. Methods: Patients with PDAC were screened post-surgical resection and enrolled in a 16-week, progressive, concurrent exercise programme alongside their chemotherapy regimen. Feasibility was the primary objective detailing recruitment, retention and adherence rates throughout as well as the safety and fidelity of the intervention. Secondarily, the impact on functional fitness and patient-reported outcomes was captured at baseline, post-intervention and 3-month follow up. Results: Eight patients consented to participate in this trial, with five proceeding to enrol in exercise training. Concurrent exercise training is feasible and safe during adjuvant chemotherapy and prevented an expected decline in functional fitness and patient-reported outcomes during this time. Discussion: This case series provides preliminary evidence that concurrent exercise training during adjuvant therapy is safe, feasible and well tolerated, preventing an expected decline in functional fitness, muscular strength and health-related quality of life (HRQoL). Given the adverse effects of treatment, these findings are promising and provide further evidence for the inclusion of exercise training as a standard of care for surgical rehabilitation and managing treatment-related toxicities. Future research should explore the impact of exercise training during neoadjuvant chemotherapy, with prehabilitation now standard practice for borderline resectable disease. Trial registration: ClinicalTrials.gov Identifier: NCT04305067, prospectively registered 12/03/2020, https://classic.clinicaltrials.gov/ct2/show/NCT04305067 .
Citation
Brown, M., O’Connor, D., Turkington, R., Eatock, M., Vince, R., Hulme, C., …Prue, G. (2023). Feasibility of delivering supervised exercise training following surgical resection and during adjuvant chemotherapy for pancreatic ductal adenocarcinoma (PRECISE): a case series. BMC Sports Science, Medicine and Rehabilitation, 15(1), Article 116. https://doi.org/10.1186/s13102-023-00722-3
Journal Article Type | Article |
---|---|
Acceptance Date | Sep 5, 2023 |
Online Publication Date | Sep 21, 2023 |
Publication Date | Dec 1, 2023 |
Deposit Date | Sep 22, 2023 |
Publicly Available Date | Sep 26, 2023 |
Journal | BMC Sports Science, Medicine and Rehabilitation |
Print ISSN | 2052-1847 |
Electronic ISSN | 2052-1847 |
Publisher | BioMed Central |
Peer Reviewed | Peer Reviewed |
Volume | 15 |
Issue | 1 |
Article Number | 116 |
DOI | https://doi.org/10.1186/s13102-023-00722-3 |
Keywords | Pancreatic ductal adenocarcinoma; Exercise; Feasibility; Functional fitness; Patient-reported outcomes |
Public URL | https://hull-repository.worktribe.com/output/4395298 |
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© 2023 The author(s).
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
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