Ming Zhang
Compartmentalized droplets for continuous flow liquid-liquid interface catalysis
Zhang, Ming; Wei, Lijuan; Chen, Huan; Du, Zhiping; Binks, Bernard P.; Yang, Hengquan
Authors
Lijuan Wei
Huan Chen
Zhiping Du
Professor Bernie Binks B.P.Binks@hull.ac.uk
Emeritus Professor of Physical Chemistry
Hengquan Yang
Abstract
To address the limitations of batch organic-aqueous biphasic catalysis, we develop a conceptually novel method termed Flow Pickering Emulsion or FPE, to process biphasic reactions in a continuous flow fashion. This method involves the compartmentalization of bulk water into micron-sized droplets based on a water-in-oil Pickering emulsion, which are packed into a column reactor. The compartmentalized water droplets can confine water-soluble catalysts, thus “immobilizing” the catalyst in the column reactor, while the interstices between the droplets allow the organic (oil) phase to flow. Key fundamental principles underpinning this method such as the oil phase flow behavior, the stability of compartmentalized droplets and the confinement capability of these droplets towards water-soluble catalysts are experimentally and theoretically investigated. As a proof of this concept, case studies including a sulphuric acid-catalyzed addition reaction, a heteropolyacid-catalyzed ring opening reaction and an enzyme-catalyzed chiral reaction demonstrate the generality and versatility of the FPE method. Impressively, in addition to the excellent durability, the developed FPE reactions exhibit up to 10-fold reaction efficiency enhancement in comparison to the existing batch reactions, indicating a unique flow interface catalysis effect. This study opens up a new avenue to allow conventional biphasic catalysis reactions to access more sustainable and efficient flow chemistry using an innovative liquid-liquid interface protocol.
Citation
Zhang, M., Wei, L., Chen, H., Du, Z., Binks, B. P., & Yang, H. (2016). Compartmentalized droplets for continuous flow liquid-liquid interface catalysis. Journal of the American Chemical Society, 138(32), 10173-10183. https://doi.org/10.1021/jacs.6b04265
Journal Article Type | Article |
---|---|
Acceptance Date | Jul 18, 2016 |
Online Publication Date | Jul 18, 2016 |
Publication Date | Aug 17, 2016 |
Deposit Date | Jul 21, 2016 |
Publicly Available Date | Jul 21, 2016 |
Journal | Journal of the American Chemical Society |
Print ISSN | 0002-7863 |
Publisher | American Chemical Society |
Peer Reviewed | Peer Reviewed |
Volume | 138 |
Issue | 32 |
Pages | 10173-10183 |
DOI | https://doi.org/10.1021/jacs.6b04265 |
Keywords | Flow Pickering Emulsion |
Public URL | https://hull-repository.worktribe.com/output/441494 |
Publisher URL | http://pubs.acs.org/doi/abs/10.1021/jacs.6b04265 |
Additional Information | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of the American Chemical Society, copyright © American Chemical Society after peer review and technical editing by the publisher.To access the final edited and published work see http://dx.doi.org/10.1021/jacs.6b04265 |
Contract Date | Jul 21, 2016 |
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Copyright Statement
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of the American Chemical Society, copyright © American Chemical Society after peer review and technical editing by the publisher.To access the final edited and published work see http://dx.doi.org/10.1021/jacs.6b04265
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Copyright Statement
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of the American Chemical Society, copyright © American Chemical Society after peer review and technical editing by the publisher.To access the final edited and published work see http://dx.doi.org/10.1021/jacs.6b04265
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