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RHOBTB2 (Rho-related BTB domain containing 2)

Cai, Shuo; Rivero-Crespo, Francisco; Schenková, Kristína

Authors

Shuo Cai

Kristína Schenková



Abstract

RhoBTB2 is one of the three members of the RhoBTB family. All RhoBTB proteins are characterized by a GTPase domain followed by a proline-rich region, a tandem of two BTB domains and a C-terminal putative RING finger domain. RHOBTB2 is a putative tumour suppressor gene. Expression of RHOBTB2 has been found decreased in breast, lung and bladder tumors, head and neck squamous cell carcinoma and osteosarcoma. Decreased expression is often the result of promoter methylation. Mutations are uncommon. The role of RhoBTB2 in tumorigenesis is unknown but may be related to its function as a component of Cullin 3-dependent ubiquitin ligase complexes regulating the cell cycle and apoptosis.

Citation

Cai, S., Rivero-Crespo, F., & Schenková, K. (2016). RHOBTB2 (Rho-related BTB domain containing 2). Atlas of genetics and cytogenetics in oncology and haematology,

Acceptance Date Feb 1, 2016
Publication Date 2016-02
Deposit Date Aug 26, 2016
Publicly Available Date Mar 28, 2024
Journal Atlas of genetics and cytogenetics in oncology and haematology
Print ISSN 1768-3262
Peer Reviewed Peer Reviewed
Keywords RhoBTB2
Public URL https://hull-repository.worktribe.com/output/442646
Publisher URL http://atlasgeneticsoncology.org/Genes/RHOBTB2ID42109ch8p21.html
Additional Information This is a copy of an open access article published in: Atlas of genetics and cytogenetics in oncology and haematology, 2016.