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Impact of Surface Ligand on the Biocompatibility of InP/ZnS Quantum Dots with Platelets

Gil, Hélio M.; Booth, Zoe; Price, Thomas W.; Lee, Jessica; Naylor‐Adamson, Leigh; Avery, Michelle; Muravitskaya, Alina; Hondow, Nicole; Allsup, David; Schneider, Jürgen E.; Naseem, Khalid; Adawi, Ali M.; Bouillard, Jean Sebastien G.; Chamberlain, Thomas W.; Calaminus, Simon D.J.; Stasiuk, Graeme J.


Hélio M. Gil

Zoe Booth

Thomas W. Price

Jessica Lee

Leigh Naylor‐Adamson

Michelle Avery

Alina Muravitskaya

Nicole Hondow

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Dr David Allsup
Senior Lecturer in Haematology and Honorary Consultant

Jürgen E. Schneider

Khalid Naseem

Thomas W. Chamberlain


InP/ZnS quantum dots (QDs) have received a large focus in recent years as a safer alternative to heavy metal-based QDs. Given their intrinsic fluorescent imaging capabilities, these QDs can be potentially relevant for in vivo platelet imaging. The InP/ZnS QDs are synthesized and their biocompatibility investigated through the use of different phase transfer agents. Analysis of platelet function indicates that platelet-QD interaction can occur at all concentrations and for all QD permutations tested. However, as the QD concentration increases, platelet aggregation is induced by QDs alone independent of natural platelet agonists. This study helps to define a range of concentrations and coatings (thioglycolic acid and penicillamine) that are biocompatible with platelet function. With this information, the platelet-QD interaction can be identified using multiple methods. Fluorescent lifetime imaging microscopy (FLIM) and confocal studies have shown QDs localize on the surface of the platelet toward the center while showing evidence of energy transfer within the QD population. It is believed that these findings are an important stepping point for the development of fluorescent probes for platelet imaging.


Gil, H. M., Booth, Z., Price, T. W., Lee, J., Naylor‐Adamson, L., Avery, M., …Stasiuk, G. J. (in press). Impact of Surface Ligand on the Biocompatibility of InP/ZnS Quantum Dots with Platelets. Small, Article 2304881.

Journal Article Type Article
Acceptance Date Oct 26, 2023
Online Publication Date Nov 9, 2023
Deposit Date Nov 15, 2023
Publicly Available Date Nov 16, 2023
Journal Small
Print ISSN 1613-6810
Electronic ISSN 1613-6829
Publisher Wiley
Peer Reviewed Peer Reviewed
Article Number 2304881
Keywords Fluorescence lifetime imaging microscopy (FLIM); Fluorescence; Hot-injections; InP/ZnS quantum dots (QDs); Platelet imaging; Platelets biocompatibility
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Copyright Statement
©2023 The Authors. Small published by Wiley-VCH GmbH. This is an
open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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