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Vitamin D3 supplementation of a high fat high sugar diet ameliorates prediabetic phenotype in female LDLR–/–and LDLR+/+mice

Carroll, Sean; Hobkirk, James; Browning, Michael J.; Janus, Justyna; Kheder, Ramiar; Saeed, Zeayd; Stover, Cordula

Authors

Michael J. Browning

Justyna Janus

Ramiar Kheder

Zeayd Saeed

Cordula Stover

Abstract

© 2017 The Authors. Immunity, Inflammation and Disease Published by John Wiley & Sons Ltd. INTRODUCTION: Fatty liver disease is prevalent in populations with high caloric intake. Nutritherapeutic approaches are being considered, such as supplementary Vitamin D 3 , to improve aspects of metabolic syndrome, namely fatty liver disease, hyperlipidemia, and insulin resistance associated with obesity. METHODS: We analyzed female LDLR -/- and LDLR +/+ mice on a 10-week diabetogenic diet for markers of fatty liver disease, metabolic strain, and inflammation. RESULTS: The groups on a high fat high sugar diet with supplementary Vitamin D 3 , in comparison with the groups on a high fat high sugar diet alone, showed improved transaminase levels, significantly less hypertriglyceridemia and hyperinsulinemia, and histologically, there was less pericentral hepatic steatosis. Levels of non-esterified fatty acids and lipid peroxidation products were significantly lower in the group supplemented with additional Vitamin D 3 , as were systemic markers of inflammation (serum endotoxin and IL-6). M2 macrophage phenotype predominated in the group supplemented with additional Vitamin D 3 . Beneficial changes were observed as early as five weeks’ supplementation with Vitamin D 3 and extended to restoration of high fat high sugar diet induced decrease of bone mineral density. CONCLUSION: In summary, Vitamin D 3 was a significantly beneficial dietary additive to blunt a prediabetic phenotype in diet-induced obesity of female LDLR -/- and LDLR +/+ mice.

Journal Article Type Article
Publication Date 2017-06
Journal Immunity, inflammation and disease
Electronic ISSN 2050-4527
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 5
Issue 2
Pages 151-154
DOI https://doi.org/10.1002/iid3.154
Keywords Diet; Metabolic syndrome; Mouse study; Vitamin D
Publisher URL http://onlinelibrary.wiley.com/doi/10.1002/iid3.154/abstract?
Copyright Statement © 2017 The Authors. Immunity, Inflammation and Disease Published by John Wiley & Sons Ltd.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Additional Information Copy of article first published in: Immunity, inflammation and disease, 2017.

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AM - Accepted Manuscript



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