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Estimated peak functional capacity: an accurate method for assessing change in peak oxygen consumption after cardiac rehabilitation?

Nichols, S.; Gleadall-Siddall, D. O.; Antony, R.; Clark, A. L.; Cleland, J. G. F.; Carroll, S.; Ingle, L.


S. Nichols

D. O. Gleadall-Siddall

R. Antony

A. L. Clark

J. G. F. Cleland


Summary Objective Cardiopulmonary exercise testing (CPET) is the ‘gold standard’ method of determining VO2peak. When CPET is unavailable, VO2peak may be estimated from treadmill or cycle ergometer workloads and expressed as estimated metabolic equivalents (METs). Cardiac rehabilitation (CR) programmes use estimated VO2peak (METs) to report changes in cardiorespiratory fitness (CRF). However, the accuracy of determining changes in VO2peak based on estimated functional capacity is not known. Methods A total of 27 patients with coronary heart disease (88·9% male; age 59·5 ± 10·0 years, body mass index 29·6 ± 3·8 kg m−2) performed maximal CPET before and after an exercise-based CR intervention. VO2peak was directly determined using ventilatory gas exchange data and was also estimated using the American College of Sports Medicine (ACSM) leg cycling equation. Agreement between changes in directly determined VO2peak and estimated VO2peak was evaluated using Bland–Altman limits of agreement (LoA) and intraclass correlation coefficients. Results Directly determined VO2peak did not increase following CR (0·5 ml kg−1 min−1 (2·7%); P = 0·332). Estimated VO2peak increased significantly (0·4 METs; 1·4 ml kg−1 min−1; 6·7%; P = 0·006). The mean bias for estimated VO2peak versus directly determined VO2peak was 0·7 ml kg−1 min−1 (LoA −4·7 to 5·9 ml kg−1 min−1). Aerobic efficiency (ΔVO2/ΔWR slope) was significantly associated with estimated VO2peak measurement error. Conclusion Change in estimated VO2peak derived from the ACSM leg cycling equation is not an accurate surrogate for directly determined changes in VO2peak. Our findings show poor agreement between estimates of VO2peak and directly determined VO2peak. Applying estimates of VO2peak to determine CRF change may over-estimate the efficacy of CR and lead to a different interpretation of study findings.


Nichols, S., Gleadall-Siddall, D. O., Antony, R., Clark, A. L., Cleland, J. G. F., Carroll, S., & Ingle, L. (2018). Estimated peak functional capacity: an accurate method for assessing change in peak oxygen consumption after cardiac rehabilitation?. Clinical physiology and functional imaging, 38(4), 681-688.

Journal Article Type Article
Acceptance Date Jul 14, 2017
Online Publication Date Aug 30, 2017
Publication Date Jul 1, 2018
Deposit Date Sep 14, 2017
Publicly Available Date Sep 3, 2018
Journal Clinical physiology and functional imaging
Print ISSN 1475-0961
Electronic ISSN 1475-097X
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 38
Issue 4
Pages 681-688
Keywords Cardiac rehabilitation; Cardiopulmonary exercise testing; Coronary heart disease; Estimated VO 2peak; Exercise testing; Metabolic equivalents; METs; VO 2peak
Public URL
Publisher URL;jsessionid=D13B54426F04D51F4C3E6C39B07FE2A5.f04t03
Additional Information This is the accepted manuscript of an article published in Clinical physiology and functional imaging, 2018. The version of record is available at the DOI link in this record.


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