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Quantum Dot Imaging Agents: Haematopoietic Cell Interactions and Biocompatibility

Naylor-Adamson, Leigh; Price, Thomas W.; Booth, Zoe; Stasiuk, Graeme J.; Calaminus, Simon D.J.

Authors

Leigh Naylor-Adamson

Thomas W. Price

Zoe Booth

Graeme J. Stasiuk



Abstract

Quantum dots (QDs) are semi-conducting nanoparticles that have been developed for a range of biological and non-biological functions. They can be tuned to multiple different emission wavelengths and can have significant benefits over other fluorescent systems. Many studies have utilised QDs with a cadmium-based core; however, these QDs have since been shown to have poor biological compatibility. Therefore, other QDs, such as indium phosphide QDs, have been developed. These QDs retain excellent fluorescent intensity and tunability but are thought to have elevated biological compatibility. Herein we discuss the applicability of a range of QDs to the cardiovascular system. Key disease states such as myocardial infarction and stroke are associated with cardiovascular disease (CVD), and there is an opportunity to improve clinical imaging to aide clinical outcomes for these disease states. QDs offer potential clinical benefits given their ability to perform multiple functions, such as carry an imaging agent, a therapy, and a targeting motif. Two key cell types associated with CVD are platelets and immune cells. Both cell types play key roles in establishing an inflammatory environment within CVD, and as such aid the formation of pathological thrombi. However, it is unclear at present how and with which cell types QDs interact, and if they potentially drive unwanted changes or activation of these cell types. Therefore, although QDs show great promise for boosting imaging capability, further work needs to be completed to fully understand their biological compatibility.

Citation

Naylor-Adamson, L., Price, T. W., Booth, Z., Stasiuk, G. J., & Calaminus, S. D. (2024). Quantum Dot Imaging Agents: Haematopoietic Cell Interactions and Biocompatibility. Cells, 13(4), Article 354. https://doi.org/10.3390/cells13040354

Journal Article Type Review
Acceptance Date Feb 13, 2024
Online Publication Date Feb 18, 2024
Publication Date Feb 2, 2024
Deposit Date Mar 13, 2024
Publicly Available Date Mar 13, 2024
Journal Cells
Electronic ISSN 2073-4409
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 13
Issue 4
Article Number 354
DOI https://doi.org/10.3390/cells13040354
Keywords Quantum dots; Cardiovascular diseases; Imaging
Public URL https://hull-repository.worktribe.com/output/4577785

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