Release of VCAM-1 associated endothelial microparticles following simulated SCUBA dives

Vince, R. V.; McNaughton, L. R.; Taylor, L.; Midgley, A. W.; Laden, G.; Madden, L. A.

Abstract

Microparticles (MP) are shed into the circulation from endothelium following activation or apoptosis. Vascular cell adhesion molecule-1 (VCAM-1) is expressed on endothelial cells following activation and here we report quantification of VCAM-1 positive microparticles (VCAM + MP) following simulated SCUBA dives, breathing either air or oxygen. VCAM + MP were quantified pre-dive (09:00 and 13:00) and post-dive (+1, +3 and +15 h) on both air and oxygen dives and compared with control samples taken from the same subjects. VCAM + MP followed a similar trend in all experiments, however both dives caused a change in endothelial state, as measured by VCAM + MP. A significant increase in VCAM + MP was observed 1 h post-air dive relative to the control (p = 0.013), which was not observed after the oxygen dive (p = 0.095). Oxidative stress (TBARS) was correlated with VCAM + MP. Data presented highlights the potential of MP as a biological marker of both endothelial state and decompression illness.

Citation

Vince, R. V., McNaughton, L. R., Taylor, L., Midgley, A. W., Laden, G., & Madden, L. A. (2009). Release of VCAM-1 associated endothelial microparticles following simulated SCUBA dives. European journal of applied physiology, 105(4), 507-513. https://doi.org/10.1007/s00421-008-0927-z

• Journal Article Type: Article
• Acceptance Date: Oct 27, 2008
• Online Publication Date: Nov 12, 2008
• Publication Date: 2009-03
• Deposit Date: Nov 13, 2014
• Publicly Available Date: Nov 13, 2014
• Journal: European Journal Of Applied Physiology
• Print ISSN: 1439-6319
• Electronic ISSN: 1439-6327
• Publisher: Springer Verlag
• Peer Reviewed: Peer Reviewed
• Volume: 105
• Issue: 4
• Pages: 507-513
• DOI: https://doi.org/10.1007/s00421-008-0927-z
• Keywords: Public Health, Environmental and Occupational Health; Physiology (medical); Orthopedics and Sports Medicine; General Medicine
• Public URL: https://hull-repository.worktribe.com/output/460546