Giolanta Kogianni
Endo180 expression with cofunctional partners MT1-MMP and uPAR-uPA is correlated with prostate cancer progression
Kogianni, Giolanta; Walker, Marjorie M.; Waxman, Jonathan; Sturge, Justin
Abstract
Endo180 (CD280; MRC2; uPARAP) regulates collagen remodelling and chemotactic cell migration through cooperation with membrane type-1 matrix metalloproteinase (MT1-MMP), urokinase-type plasminogen activator receptor (uPAR) and urokinase-type plasminogen activator (uPA). One hundred and sixty nine prostate tissue sections clinically graded as benign prostatic hyperplasia (BPH) (n = 29) or prostate cancer (PCA) with Gleason scores indicating low (≤7(3 + 4); n = 26), intermediate (7(4 + 3)-8; n = 96) or high (9-10; n = 19) clinical risk were immunofluorescently stained for Endo180, pan-cytokeratin (pCk), vimentin, MT1-MMP and uPAR-uPA. Quantification of % Endo180 + /pCk - and Endo180 + /pCk + cells in entire tissue cores revealed stromal (p = 0.0001) and epithelial (p = 0.0001) upregulation of Endo180 in PCA compared to BPH. Epithelial Endo180 expression was significantly different between the three clinical risk groups of PCA (p < 0.05). Correlations with MT1-MMP and uPAR-uPA confirmed the functionality of Endo180 during PCA progression. This molecular evaluation is the first step in the exploration of Endo180 in PCA diagnosis and therapy. © 2008 Elsevier Ltd. All rights reserved.
Citation
Kogianni, G., Walker, M. M., Waxman, J., & Sturge, J. (2009). Endo180 expression with cofunctional partners MT1-MMP and uPAR-uPA is correlated with prostate cancer progression. European Journal of Cancer, 45(4), 685-693. https://doi.org/10.1016/j.ejca.2008.11.023
Journal Article Type | Article |
---|---|
Acceptance Date | Nov 10, 2008 |
Online Publication Date | Dec 26, 2008 |
Publication Date | Mar 1, 2009 |
Deposit Date | Nov 13, 2014 |
Publicly Available Date | Mar 28, 2024 |
Journal | European Journal Of Cancer |
Print ISSN | 1879-0852 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 45 |
Issue | 4 |
Pages | 685-693 |
DOI | https://doi.org/10.1016/j.ejca.2008.11.023 |
Keywords | Benign prostatic hyperplasia, Collagen receptor, Endo180, Invasion, Metastasis, Prostate cancer, Proteases, |
Public URL | https://hull-repository.worktribe.com/output/467719 |
You might also like
The toxic effect of cytostatics on primary cilia frequency and multiciliation
(2019)
Journal Article
A 18F radiolabelled Zn(ii) sensing fluorescent probe
(2018)
Journal Article
Downloadable Citations
About Repository@Hull
Administrator e-mail: repository@hull.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search