Endo180 expression with cofunctional partners MT1-MMP and uPAR-uPA is correlated with prostate cancer progression

Kogianni, Giolanta; Walker, Marjorie M.; Waxman, Jonathan; Sturge, Justin

Abstract

Endo180 (CD280; MRC2; uPARAP) regulates collagen remodelling and chemotactic cell migration through cooperation with membrane type-1 matrix metalloproteinase (MT1-MMP), urokinase-type plasminogen activator receptor (uPAR) and urokinase-type plasminogen activator (uPA). One hundred and sixty nine prostate tissue sections clinically graded as benign prostatic hyperplasia (BPH) (n = 29) or prostate cancer (PCA) with Gleason scores indicating low (≤7(3 + 4); n = 26), intermediate (7(4 + 3)-8; n = 96) or high (9-10; n = 19) clinical risk were immunofluorescently stained for Endo180, pan-cytokeratin (pCk), vimentin, MT1-MMP and uPAR-uPA. Quantification of % Endo180 + /pCk - and Endo180 + /pCk + cells in entire tissue cores revealed stromal (p = 0.0001) and epithelial (p = 0.0001) upregulation of Endo180 in PCA compared to BPH. Epithelial Endo180 expression was significantly different between the three clinical risk groups of PCA (p < 0.05). Correlations with MT1-MMP and uPAR-uPA confirmed the functionality of Endo180 during PCA progression. This molecular evaluation is the first step in the exploration of Endo180 in PCA diagnosis and therapy. © 2008 Elsevier Ltd. All rights reserved.

Citation

Kogianni, G., Walker, M. M., Waxman, J., & Sturge, J. (2009). Endo180 expression with cofunctional partners MT1-MMP and uPAR-uPA is correlated with prostate cancer progression. European Journal of Cancer, 45(4), 685-693. https://doi.org/10.1016/j.ejca.2008.11.023

• Journal Article Type: Article
• Acceptance Date: Nov 10, 2008
• Online Publication Date: Dec 26, 2008
• Publication Date: Mar 1, 2009
• Deposit Date: Nov 13, 2014
• Journal: European Journal Of Cancer
• Print ISSN: 1879-0852
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 45
• Issue: 4
• Pages: 685-693
• DOI: https://doi.org/10.1016/j.ejca.2008.11.023
• Keywords: Benign prostatic hyperplasia, Collagen receptor, Endo180, Invasion, Metastasis, Prostate cancer, Proteases,
• Public URL: https://hull-repository.worktribe.com/output/467719
• Contract Date: Nov 23, 2017