Professor Mark Lorch M.Lorch@hull.ac.uk
Professor of Public Engagement and Science Communication.
MRI contrast agent delivery using spore capsules: controlled release in blood plasma
Lorch, Mark; Thomasson, Matthew J.; Diego-Taboada, Alberto; Barrier, Sylvain; Atkin, Stephen L.; Mackenzie, Grahame; Archibald, Stephen J.
Authors
Matthew J. Thomasson
Alberto Diego-Taboada
Sylvain Barrier
Stephen L. Atkin
Grahame Mackenzie
Professor Steve Archibald S.J.Archibald@hull.ac.uk
Professor in Molecular Imaging
Abstract
The exine coatings of spores can be used to encapsulate drug molecules. We have demonstrated that these microcapsules can be filled with a commercial gadolinium(III) MRI contrast agent (in this proof of concept study Gd-DTPA-BMA was used) which is slowly released in plasma due to enzymatic digestion of the capsule.
Citation
Lorch, M., Thomasson, M. J., Diego-Taboada, A., Barrier, S., Atkin, S. L., Mackenzie, G., & Archibald, S. J. (2009). MRI contrast agent delivery using spore capsules: controlled release in blood plasma. Chemical communications : Chem comm / the Royal Society of Chemistry, 6442-6444. https://doi.org/10.1039/b909551a
| Journal Article Type | Article |
|---|---|
| Acceptance Date | Sep 8, 2009 |
| Online Publication Date | Oct 1, 2009 |
| Publication Date | Oct 1, 2009 |
| Deposit Date | Nov 13, 2014 |
| Journal | Chemical communications |
| Print ISSN | 1359-7345 |
| Publisher | Royal Society of Chemistry |
| Peer Reviewed | Peer Reviewed |
| Issue | 42 |
| Pages | 6442-6444 |
| DOI | https://doi.org/10.1039/b909551a |
| Keywords | MRI contrast agents, drug delivery, spore exine, encapsulation, gadolinium, |
| Public URL | https://hull-repository.worktribe.com/output/472887 |
| Publisher URL | http://pubs.rsc.org/en/Content/ArticleLanding/2009/CC/b909551a#!divAbstract |
| Contract Date | Nov 13, 2014 |
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