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MRI contrast agent delivery using spore capsules: controlled release in blood plasma

Barrier, S.; Diego-Taboada, A.; Atkin, S.L.; MacKenzie, G.; Archibald, S.J.; Lorch, Mark; Thomasson, Matthew J.; Atkin, Stephen; Diego-Taboada, Alberto; Barrier, Sylvain; Atkin, Stephen L.; Mackenzie, Grahame; Archibald, Stephen J.; Thomasson, Matthew

Authors

S. Barrier

A. Diego-Taboada

S.L. Atkin

G. MacKenzie

S.J. Archibald

Professor Mark Lorch M.Lorch@hull.ac.uk
Professor of Public Engagement and Science Communication. Interim Head of Department for Chemistry, Biochemistry and Chemical Engineering

Matthew J. Thomasson

Stephen Atkin

Alberto Diego-Taboada

Sylvain Barrier

Stephen L. Atkin

Grahame Mackenzie

Matthew Thomasson



Abstract

The exine coatings of spores can be used to encapsulate drug molecules. We have demonstrated that these microcapsules can be filled with a commercial gadolinium(III) MRI contrast agent (in this proof of concept study Gd-DTPA-BMA was used) which is slowly released in plasma due to enzymatic digestion of the capsule.

Citation

Lorch, M., Thomasson, M. J., Diego-Taboada, A., Barrier, S., Atkin, S. L., Mackenzie, G., & Archibald, S. J. (2009). MRI contrast agent delivery using spore capsules: controlled release in blood plasma. Chemical communications : Chem comm / the Royal Society of Chemistry, 6442-6444. https://doi.org/10.1039/b909551a

Journal Article Type Article
Acceptance Date Sep 8, 2009
Online Publication Date Oct 1, 2009
Publication Date Oct 1, 2009
Deposit Date Nov 13, 2014
Journal Chemical communications
Print ISSN 1359-7345
Electronic ISSN 1364-548X
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Issue 42
Pages 6442-6444
DOI https://doi.org/10.1039/b909551a
Keywords MRI contrast agents, drug delivery, spore exine, encapsulation, gadolinium,
Public URL https://hull-repository.worktribe.com/output/472887
Publisher URL http://pubs.rsc.org/en/Content/ArticleLanding/2009/CC/b909551a#!divAbstract