Social context prevents heat hormetic effects against mutagens during fish development

Feugere, Lauric; Silva De Freitas, Claudio; Bates, Adam; Storey, Kenneth B.; Beltran-Alvarez, Pedro; Wollenberg Valero, Katharina C.

Abstract

Since stress can be transmitted to congeners via social metabolites, it is paramount to understand how the social context of abiotic stress influences aquatic organisms' responses to global changes. Here, we integrated the transcriptomic and phenotypic responses of zebrafish embryos to a UV damage/repair assay following scenarios of heat stress, its social context and their combination. Heat stress preceding UV exposure had a hormetic effect through the cellular stress response and DNA repair, rescuing and/or protecting embryos from UV damage. However, experiencing heat stress within a social context negated this molecular hormetic effect and lowered larval fitness. We discuss the molecular basis of interindividual chemical transmission within animal groups as another layer of complexity to organisms' responses to environmental stressors.

Citation

Feugere, L., Silva De Freitas, C., Bates, A., Storey, K. B., Beltran-Alvarez, P., & Wollenberg Valero, K. C. (2025). Social context prevents heat hormetic effects against mutagens during fish development. FEBS Letters, https://doi.org/10.1002/1873-3468.70047

• Journal Article Type: Article
• Acceptance Date: Mar 28, 2025
• Online Publication Date: Apr 23, 2025
• Publication Date: 2025
• Deposit Date: Mar 28, 2025
• Publicly Available Date: Apr 28, 2025
• Print ISSN: 0014-5793
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• DOI: https://doi.org/10.1002/1873-3468.70047
• Keywords: Carryover effect; DNA repair; Heat stress; Hormetic effect; Stress communication; UV damage
• Public URL: https://hull-repository.worktribe.com/output/5090258