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Advances in processes for PET radiotracer synthesis: Separation of [18F]fluoride from enriched [18O]water

He, Ping; Haswell, Stephen J.; Pamme, Nicole; Archibald, Stephen J.


Ping He

Stephen J. Haswell

Nicole Pamme


Positron emission tomography (PET) is a powerful scientific and clinical tool for the study and visualization of human physiology that can provide important information about metabolism and diseases such as cancer. At present, [ 18 F]fluorodeoxyglucose ([ 18 F]FDG) is the most frequently used radiotracer for the routine clinical evaluation of malignant tumors in a range of body tissues. FDG synthesis is continuously being developed to improve and simplify the synthetic procedure including the isolation of [ 18 F]fluoride from [ 18 O]water. There are many methods reported in literature for the isolation of [ 18 F]fluoride, including evaporation, coat-capture-elution, the use of cation-exchange resin and electrode trapping. This review article gives an overview of some of the most common methods for the separation of [ 18 F]fluoride ions from [ 18 O]water, highlighting the potential strength of the methods and also problems and weaknesses for synthesis of 18 F PET tracers. © 2014 Elsevier Ltd.


He, P., Haswell, S. J., Pamme, N., & Archibald, S. J. (2014). Advances in processes for PET radiotracer synthesis: Separation of [18F]fluoride from enriched [18O]water. Applied radiation and isotopes : including data, instrumentation, and methods for use in agriculture, industry, and medicine, 91, 64-70.

Journal Article Type Review
Acceptance Date Apr 28, 2014
Online Publication Date May 14, 2014
Publication Date 2014-09
Deposit Date Dec 8, 2020
Journal Applied Radiation and Isotopes
Print ISSN 0969-8043
Electronic ISSN 1872-9800
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 91
Pages 64-70
Keywords Electrochemical cell; Fluorine-18; Separation; Positron emission tomography; FDG; Radiochemical synthesis
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