Advances in processes for PET radiotracer synthesis: Separation of [18F]fluoride from enriched [18O]water

He, Ping; Haswell, Stephen J.; Pamme, Nicole; Archibald, Stephen J.

Abstract

Positron emission tomography (PET) is a powerful scientific and clinical tool for the study and visualization of human physiology that can provide important information about metabolism and diseases such as cancer. At present, [ 18 F]fluorodeoxyglucose ([ 18 F]FDG) is the most frequently used radiotracer for the routine clinical evaluation of malignant tumors in a range of body tissues. FDG synthesis is continuously being developed to improve and simplify the synthetic procedure including the isolation of [ 18 F]fluoride from [ 18 O]water. There are many methods reported in literature for the isolation of [ 18 F]fluoride, including evaporation, coat-capture-elution, the use of cation-exchange resin and electrode trapping. This review article gives an overview of some of the most common methods for the separation of [ 18 F]fluoride ions from [ 18 O]water, highlighting the potential strength of the methods and also problems and weaknesses for synthesis of 18 F PET tracers. © 2014 Elsevier Ltd.

Citation

He, P., Haswell, S. J., Pamme, N., & Archibald, S. J. (2014). Advances in processes for PET radiotracer synthesis: Separation of [18F]fluoride from enriched [18O]water. Applied radiation and isotopes : including data, instrumentation, and methods for use in agriculture, industry, and medicine, 91, 64-70. https://doi.org/10.1016/j.apradiso.2014.04.021

• Journal Article Type: Review
• Acceptance Date: Apr 28, 2014
• Online Publication Date: May 14, 2014
• Publication Date: 2014-09
• Deposit Date: Dec 8, 2020
• Journal: Applied Radiation and Isotopes
• Print ISSN: 0969-8043
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 91
• Pages: 64-70
• DOI: https://doi.org/10.1016/j.apradiso.2014.04.021
• Keywords: Electrochemical cell; Fluorine-18; Separation; Positron emission tomography; FDG; Radiochemical synthesis
• Public URL: https://hull-repository.worktribe.com/output/518558
• Publisher URL: https://www.sciencedirect.com/science/article/abs/pii/S0969804314001602?via%3Dihub