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Microfluidic culture of head and neck tumour maintains viability, as shown by single cell analysis, providing potential for novel applications and personalised medicine

Bower, Ruth; Green, Victoria; Kuvshinov, Dmitriy; Crank, Stephen; Stafford, Nicholas; Greenman, John

Authors

Ruth Bower

Victoria Green

Dmitriy Kuvshinov

Stephen Crank

Nicholas Stafford



Abstract

The current paper details a succinct characterisation of an in-house designed microfluidic culture device. The maintenance of tissue viability was determined by studying single cells, following dissociation, of head and neck tumour pre and post culture. In addition, irradiation schedules have been elucidated using cell lines for transfer to the on-chip model. This provides a platform for a move towards personalised medicine in which the interrogation of biopsies on-chip will provide an evidence-base for treatment. (Fig 1.).

Start Date Oct 9, 2016
Publication Date Jan 1, 2016
Pages 535-536
ISBN 9780979806490
APA6 Citation Bower, R., Green, V., Kuvshinov, D., Crank, S., Stafford, N., & Greenman, J. (2016). Microfluidic culture of head and neck tumour maintains viability, as shown by single cell analysis, providing potential for novel applications and personalised medicine