Microfluidic culture of head and neck tumour maintains viability, as shown by single cell analysis, providing potential for novel applications and personalised medicine

Bower, Ruth; Green, Victoria; Kuvshinov, Dmitriy; Crank, Stephen; Stafford, Nicholas; Greenman, John

Abstract

The current paper details a succinct characterisation of an in-house designed microfluidic culture device. The maintenance of tissue viability was determined by studying single cells, following dissociation, of head and neck tumour pre and post culture. In addition, irradiation schedules have been elucidated using cell lines for transfer to the on-chip model. This provides a platform for a move towards personalised medicine in which the interrogation of biopsies on-chip will provide an evidence-base for treatment. (Fig 1.).

Citation

Bower, R., Green, V., Kuvshinov, D., Crank, S., Stafford, N., & Greenman, J. (2016). Microfluidic culture of head and neck tumour maintains viability, as shown by single cell analysis, providing potential for novel applications and personalised medicine.

• Conference Name: 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
• Conference Location: Dublin, Ireland
• Start Date: Oct 9, 2016
• End Date: Oct 13, 2016
• Acceptance Date: Jan 1, 2016
• Publication Date: Jan 1, 2016
• Deposit Date: Jun 11, 2019
• Pages: 535-536
• ISBN: 9780979806490
• Public URL: https://hull-repository.worktribe.com/output/520444