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The effect of a simulated commercial flight environment with hypoxia and low humidity on clotting, platelet, and endothelial function in participants with type 2 diabetes - A cross-over study

Konya, Judit; Spurgeon, Benjamin E. J.; Al Qaissi, Ahmed; Sathyapalan, Thozhukat; Ajjan, Ramzi; Madden, Leigh; Naseem, Khalid M.; Garrett, Andrew Thomas; Kilpatrick, Eric; Atkin, Stephen L.

Authors

Judit Konya

Benjamin E. J. Spurgeon

Ahmed Al Qaissi

Thozhukat Sathyapalan

Ramzi Ajjan

Leigh Madden

Khalid M. Naseem

Andrew Thomas Garrett

Eric Kilpatrick

Stephen L. Atkin



Contributors

Abstract

© 2018 Konya, Al Qaissi, Sathyapalan, Ajjan, Madden, Naseem, Garrett, Kilpatrick and Atkin. Aims: To determine if clotting, platelet, and endothelial function were affected by simulated short-haul commercial air flight conditions (SF) in participants with type 2 diabetes (T2DM) compared to controls. Methods: 10 participants with T2DM (7 females, 3 males) and 10 controls (3 females, 7 males) completed the study. Participants were randomized to either spend 2 h in an environmental chamber at sea level conditions (temperature: 23°C, oxygen concentration 21%, humidity 45%), or subject to a simulated 2-h simulated flight (SF: temperature: 23°C, oxygen concentration 15%, humidity 15%), and crossed over 7 days later. Main outcome measures: clot formation and clot lysis parameters, functional platelet activation markers, and endothelial function measured by reactive hyperemia index (RHI) by EndoPAT and serum microparticles. Results: Comparing baseline with SF conditions, clot maximal absorption was increased in controls (0.375 ± 0.05 vs. 0.39 ± 0.05, p < 0.05) and participants with T2DM (0.378 ± 0.089 vs. 0.397 ± 0.089, p < 0.01), while increased basal platelet activation for both fibrinogen binding and P-selectin expression (p < 0.05) was seen in participants with T2DM. Parameters of clot formation and clot lysis, stimulated platelet function (stimulated platelet response to ADP and sensitivity to prostacyclin), and endothelial function were unchanged. Conclusion: While SF resulted in the potential of denser clot formation with enhanced basal platelet activation in T2DM, the dynamic clotting, platelet, and endothelial markers were not affected, suggesting that short-haul commercial flying adds no additional hazard for venous thromboembolism for participants with T2DM compared to controls.

Journal Article Type Article
Publication Date Feb 13, 2018
Print ISSN 1664-2392
Electronic ISSN 1664-2392
Publisher Frontiers Media
Peer Reviewed Peer Reviewed
Volume 9
Issue FEB
Article Number 26
APA6 Citation Konya, J., Spurgeon, B. E. J., Al Qaissi, A., Sathyapalan, T., Ajjan, R., Madden, L., …Atkin, S. L. (2018). The effect of a simulated commercial flight environment with hypoxia and low humidity on clotting, platelet, and endothelial function in participants with type 2 diabetes - A cross-over study. Frontiers in endocrinology, 9(FEB), https://doi.org/10.3389/fendo.2018.00026
DOI https://doi.org/10.3389/fendo.2018.00026
Keywords Type 2 diabetes; Hypoxia; Flight simulation; Platelet function; Endothelial function; Clotting
Publisher URL https://www.frontiersin.org/articles/10.3389/fendo.2018.00026/full
Copyright Statement © 2018 Konya, Al Qaissi, Sathyapalan, Ajjan, Madden, Naseem, Garrett, Kilpatrick and Atkin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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