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Protein free microcapsules obtained from plant spores as a model for drug delivery: Ibuprofen encapsulation, release and taste masking

Diego-Taboada, Alberto; Maillet, Laurent; Banoub, Joseph H.; Lorch, Mark; Rigby, Alan S.; Boa, Andrew N.; Atkin, Stephen L.; Mackenzie, Grahame

Authors

Alberto Diego-Taboada

Laurent Maillet

Joseph H. Banoub

Professor Mark Lorch M.Lorch@hull.ac.uk
Professor of Public Engagement and Science Communication. Interim Head of Department for Chemistry, Biochemistry and Chemical Engineering

Alan S. Rigby

Stephen L. Atkin

Grahame Mackenzie



Abstract

Sporopollenin exine capsules (SEC) extracted from Lycopodium clavatum spores were shown to encapsulate ibuprofen as a drug model, with 97 ± 1% efficiency as measured by recovery of the loaded drug and absence of the drug on the SEC surface by scanning electron microscopy (SEM). The encapsulated ibuprofen was shown to be unchanged from its bulk crystalline form by solid state NMR, FTIR and XRD. Essential for drug delivery applications, SEC were shown to be non-toxic to human endothelial cells and free of allergenic protein epitopes by MALDI-TOF-MS and ESI-QqToF-MS. Potential application for targeted release into the intestinal region of the gastrointestinal tract (GIT) was demonstrated by 88 ± 1% of the drug being retained in simulated gastric fluid (SGF) after 45 minutes and 85 ± 2% being released after 5 min in buffer (PBS; pH 7.4). The SEC were shown to provide significant taste masking of encapsulated ibuprofen in a double blind trial with 10 human volunteers. © The Royal Society of Chemistry 2013.

Journal Article Type Article
Publication Date Feb 7, 2013
Journal Journal of Materials Chemistry B
Print ISSN 2050-750X
Electronic ISSN 2050-750X
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 1
Issue 5
Pages 707-713
APA6 Citation Diego-Taboada, A., Maillet, L., Banoub, J. H., Lorch, M., Rigby, A. S., Boa, A. N., …Mackenzie, G. (2013). Protein free microcapsules obtained from plant spores as a model for drug delivery: Ibuprofen encapsulation, release and taste masking. Journal of Materials Chemistry B, 1(5), 707-713. https://doi.org/10.1039/c2tb00228k
DOI https://doi.org/10.1039/c2tb00228k
Publisher URL https://www.scopus.com/inward/record.uri?eid=2-s2.0-84876526833&doi=10.1039%2fc2tb00228k&partnerID=40&md5=c228578ff95783fe380bf7e840f000ca
Copyright Statement This Open Access Article is licensed under a Creative Commons Attribution 3.0 Unported Licence DOI: 10.1039/C2TB00228K (Paper) J. Mater. Chem. B, 2013, 1, 707-713

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Copyright Statement
This Open Access Article is licensed under a Creative Commons Attribution 3.0 Unported Licence DOI: 10.1039/C2TB00228K (Paper) J. Mater. Chem. B, 2013, 1, 707-713





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