Soy isoflavones improve cardiovascular disease risk markers in women during 1 the early menopause 2 1

Sathyapalan, Thozhukat; Aye, Myint; Rigby, Alan S; Thatcher, Natalie J; Dargham, Soha R; Kilpatrick, Eric S; Atkin, Stephen L

Abstract

Background
Hormone replacement therapy may be beneficial for cardiovascular disease risk (CVR) in post-menopausal women. Soy isoflavones may act as selective estrogen receptor modulators. The aim of this study was to evaluate whether soy isoflavones had an effect on CVR markers.

Methods
The expected 10-year risk of cardiovascular disease and mortality were calculated as a secondary endpoint from a double blind randomised parallel study involving 200 women (mean age 55 years, Caucasian, Hull, UK, 2012) in the early menopause who were randomised to 15 g soy protein with 66 mg isoflavone (SPI) or 15 g soy protein alone (depleted of all isoflavones; SP) given as a snack bar between meals daily for 6 months. Age, diabetes, smoking, blood pressure and lipid profiles were used to calculate CVR using the Framingham CVR engine.

Results
SPI treatment resulted in a significant reduction in the metabolic parameters and systolic blood pressure compared to SP (p < 0.01). There were no changes in fasting lipid profile and diastolic blood pressure with either treatment. At 6 months, changes in these parameters with SPI treatment were reflected in a calculated 27% (p < 0.01) reduction in 10 year coronary heart disease risk, a 37% (p < 0.01) reduction in myocardial infarction risk, a 24% (p < 0.04) reduction in cardiovascular disease and 42% (p < 0.02) reduction in cardiovascular disease death risk.

Conclusions
Supplementation with soy protein with isoflavones for 6 months significantly improved CVR markers and calculated CVR at 6 months during early menopause compared to soy protein without isoflavones.

Citation

Sathyapalan, T., Aye, M., Rigby, A. S., Thatcher, N. J., Dargham, S. R., Kilpatrick, E. S., & Atkin, S. L. (2018). Soy isoflavones improve cardiovascular disease risk markers in women during 1 the early menopause 2 1. Nutrition, metabolism, and cardiovascular diseases : NMCD, 28(7), 691-697. https://doi.org/10.1016/j.numecd.2018.03.007

• Journal Article Type: Article
• Acceptance Date: Mar 13, 2018
• Online Publication Date: Apr 10, 2018
• Publication Date: 2018-07
• Deposit Date: May 6, 2018
• Publicly Available Date: Apr 11, 2019
• Print ISSN: 0939-4753
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 28
• Issue: 7
• Pages: 691-697
• DOI: https://doi.org/10.1016/j.numecd.2018.03.007
• Keywords: Soy; Isoflavones; Cardiovascular risk; Stroke; Cardiovascular death; Cardiovascular disease; Postmenopausal
• Public URL: https://hull-repository.worktribe.com/output/743436
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S093947531830098X?via%3Dihub