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Soy isoflavones improve cardiovascular disease risk markers in women during 1 the early menopause 2 1

Sathyapalan, Thozhukat; Aye, Myint; Rigby, Alan S; Thatcher, Natalie J; Dargham, Soha R; Kilpatrick, Eric S; Atkin, Stephen L


Myint Aye

Natalie J Thatcher

Soha R Dargham

Eric S Kilpatrick

Stephen L Atkin


Hormone replacement therapy may be beneficial for cardiovascular disease risk (CVR) in post-menopausal women. Soy isoflavones may act as selective estrogen receptor modulators. The aim of this study was to evaluate whether soy isoflavones had an effect on CVR markers.

The expected 10-year risk of cardiovascular disease and mortality were calculated as a secondary endpoint from a double blind randomised parallel study involving 200 women (mean age 55 years, Caucasian, Hull, UK, 2012) in the early menopause who were randomised to 15 g soy protein with 66 mg isoflavone (SPI) or 15 g soy protein alone (depleted of all isoflavones; SP) given as a snack bar between meals daily for 6 months. Age, diabetes, smoking, blood pressure and lipid profiles were used to calculate CVR using the Framingham CVR engine.

SPI treatment resulted in a significant reduction in the metabolic parameters and systolic blood pressure compared to SP (p < 0.01). There were no changes in fasting lipid profile and diastolic blood pressure with either treatment. At 6 months, changes in these parameters with SPI treatment were reflected in a calculated 27% (p < 0.01) reduction in 10 year coronary heart disease risk, a 37% (p < 0.01) reduction in myocardial infarction risk, a 24% (p < 0.04) reduction in cardiovascular disease and 42% (p < 0.02) reduction in cardiovascular disease death risk.

Supplementation with soy protein with isoflavones for 6 months significantly improved CVR markers and calculated CVR at 6 months during early menopause compared to soy protein without isoflavones.


Sathyapalan, T., Aye, M., Rigby, A. S., Thatcher, N. J., Dargham, S. R., Kilpatrick, E. S., & Atkin, S. L. (2018). Soy isoflavones improve cardiovascular disease risk markers in women during 1 the early menopause 2 1. Nutrition, metabolism, and cardiovascular diseases : NMCD, 28(7), 691-697.

Journal Article Type Article
Acceptance Date Mar 13, 2018
Online Publication Date Apr 10, 2018
Publication Date 2018-07
Deposit Date May 6, 2018
Publicly Available Date Apr 11, 2019
Print ISSN 0939-4753
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 28
Issue 7
Pages 691-697
Keywords Soy; Isoflavones; Cardiovascular risk; Stroke; Cardiovascular death; Cardiovascular disease; Postmenopausal
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