The kinin–kallikrein system: physiological roles, pathophysiology and its relationship to cancer biomarkers

Kashuba, Elena; Bailey, James; Allsup, David; Cawkwell, Lynn

Abstract

The kinin–kallikrein system (KKS) is an endogenous multiprotein cascade, the activation of which leads to triggering of the intrinsic coagulation pathway and enzymatic hydrolysis of kininogens with the consequent release of bradykinin-related peptides. This system plays a crucial role in inflammation, vasodilation, smooth muscle contraction, cardioprotection, vascular permeability, blood pressure control, coagulation and pain. In this review, we will outline the physiology and pathophysiology of the KKS and also highlight the association of this system with carcinogenesis and cancer progression.

Citation

Kashuba, E., Bailey, J., Allsup, D., & Cawkwell, L. (2013). The kinin–kallikrein system: physiological roles, pathophysiology and its relationship to cancer biomarkers. Biomarkers, 18(4), 279-296. https://doi.org/10.3109/1354750x.2013.787544

• Journal Article Type: Review
• Acceptance Date: Mar 16, 2013
• Online Publication Date: May 15, 2013
• Publication Date: May 29, 2013
• Deposit Date: Mar 22, 2018
• Journal: Biomarkers
• Print ISSN: 1354-750X
• Electronic ISSN: 1366-5804
• Publisher: Taylor and Francis
• Peer Reviewed: Peer Reviewed
• Volume: 18
• Issue: 4
• Pages: 279-296
• DOI: https://doi.org/10.3109/1354750x.2013.787544
• Keywords: Clinical Biochemistry; Biochemistry; Health, Toxicology and Mutagenesis
• Public URL: https://hull-repository.worktribe.com/output/752416
• Publisher URL: https://www.tandfonline.com/doi/full/10.3109/1354750X.2013.787544