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The kinin–kallikrein system: physiological roles, pathophysiology and its relationship to cancer biomarkers

Kashuba, Elena; Bailey, James; Allsup, David; Cawkwell, Lynn

Authors

Elena Kashuba

James Bailey

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Dr David Allsup hycda1@hyms.ac.uk
Senior Lecturer in Haematology and Honorary Consultant

Lynn Cawkwell



Abstract

The kinin–kallikrein system (KKS) is an endogenous multiprotein cascade, the activation of which leads to triggering of the intrinsic coagulation pathway and enzymatic hydrolysis of kininogens with the consequent release of bradykinin-related peptides. This system plays a crucial role in inflammation, vasodilation, smooth muscle contraction, cardioprotection, vascular permeability, blood pressure control, coagulation and pain. In this review, we will outline the physiology and pathophysiology of the KKS and also highlight the association of this system with carcinogenesis and cancer progression.

Citation

Kashuba, E., Bailey, J., Allsup, D., & Cawkwell, L. (2013). The kinin–kallikrein system: physiological roles, pathophysiology and its relationship to cancer biomarkers. Biomarkers, 18(4), (279-296). doi:10.3109/1354750x.2013.787544. ISSN 1354-750X

Journal Article Type Review
Acceptance Date Mar 16, 2013
Online Publication Date May 15, 2013
Publication Date May 29, 2013
Deposit Date Mar 22, 2018
Journal Biomarkers
Print ISSN 1354-750X
Electronic ISSN 1366-5804
Publisher Taylor & Francis
Peer Reviewed Peer Reviewed
Volume 18
Issue 4
Pages 279-296
DOI https://doi.org/10.3109/1354750x.2013.787544
Keywords Clinical Biochemistry; Biochemistry; Health, Toxicology and Mutagenesis
Public URL https://hull-repository.worktribe.com/output/752416
Publisher URL https://www.tandfonline.com/doi/full/10.3109/1354750X.2013.787544