The kinin–kallikrein system: physiological roles, pathophysiology and its relationship to cancer biomarkers

Kashuba, Elena; Bailey, James; Allsup, David; Cawkwell, Lynn

Abstract

The kinin–kallikrein system (KKS) is an endogenous multiprotein cascade, the activation of which leads to triggering of the intrinsic coagulation pathway and enzymatic hydrolysis of kininogens with the consequent release of bradykinin-related peptides. This system plays a crucial role in inflammation, vasodilation, smooth muscle contraction, cardioprotection, vascular permeability, blood pressure control, coagulation and pain. In this review, we will outline the physiology and pathophysiology of the KKS and also highlight the association of this system with carcinogenesis and cancer progression.

• Journal Article Type: Review
• Publication Date: May 29, 2013
• Journal: Biomarkers
• Print ISSN: 1354-750X
• Electronic ISSN: 1366-5804
• Publisher: Taylor & Francis
• Peer Reviewed: Peer Reviewed
• Volume: 18
• Issue: 4
• Pages: 279-296
• APA6 Citation: Kashuba, E., Bailey, J., Allsup, D., & Cawkwell, L. (2013). The kinin–kallikrein system: physiological roles, pathophysiology and its relationship to cancer biomarkers. Biomarkers, 18(4), (279-296). doi:10.3109/1354750x.2013.787544. ISSN 1354-750X
• DOI: https://doi.org/10.3109/1354750x.2013.787544
• Keywords: Clinical Biochemistry; Biochemistry; Health, Toxicology and Mutagenesis
• Publisher URL: https://www.tandfonline.com/doi/full/10.3109/1354750X.2013.787544