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Identifying patterns in signs and symptoms preceding the clinical diagnosis of Alzheimer's disease: retrospective medical record review study and a nested case -control design

Bature, Fidelia; Pang, Dong; Robinson, Anthea; Polson, Norma; Pappas, Yannis; Guinn, Barbara

Authors

Fidelia Bature

Dong Pang

Anthea Robinson

Norma Polson

Yannis Pappas



Abstract

Objective
Evidence suggests that individuals with Alzheimer’s disease (AD) are often diagnosed in the later stages of their disease with a poor prognosis. This study aimed to identify patterns in signs and symptoms preceding the clinical diagnosis of AD to suggest a predictive model for earlier diagnosis of the disease in the primary care.
Design
A retrospective medical record review; nested case control design.
Participants
Participants included one hundred and nine patients from three general practice (GP) surgeries in Milton Keynes and Luton Clinical Commissioning groups (CCG) (37 cases with ADand 72 controls without AD).
Main outcome measure
A retrospective analysis using the logistic regression of the presence of signs and symptoms before the diagnosis of AD was attained. Identification of the timing and sequence of appearance of these presentations as first reported before the clinical diagnosis was measured.
Result
Episodic memory with an odds ratio of 1.85 was the most frequent presentation, documented in 1.38% of the controls and 75.6% in cases. Auditory disturbance with an odds ratio of 3.03, which has not previously been noted except in the form of auditory hallucination, could have a diagnostic value.
Conclusion
Auditory disturbance, which occurred mostly in the Caucasian females, could discriminate individuals with ADfrom those without. The symptom, which presented up to 14.5 (mean time) years prior to clinical diagnosis, was identified in Caucasians and mixed race individuals only.

Journal Article Type Article
Publication Date Apr 4, 2018
Journal Current Alzheimer Research
Print ISSN 1567-2050
Electronic ISSN 1875-5828
Publisher Bentham Science Publishers
Peer Reviewed Peer Reviewed
Volume 15
Issue 8
Pages 723-730
APA6 Citation Bature, F., Pang, D., Robinson, A., Polson, N., Pappas, Y., & Guinn, B. (2018). Identifying patterns in signs and symptoms preceding the clinical diagnosis of Alzheimer's disease: retrospective medical record review study and a nested case -control design. Current Alzheimer Research, 15(8), 723-730. https://doi.org/10.2174/1567205015666180404155358
DOI https://doi.org/10.2174/1567205015666180404155358
Keywords Retrospective medical record review; Alzheimer’s disease; Chart review; Case-control; Early signs and symptoms; Dementia; Early diagnosis
Publisher URL https://benthamscience.com/journals/current-alzheimer-research/

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