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Lifelong exercise, but not short-term high-intensity interval training, increases GDF11, a marker of successful aging: a preliminary investigation

Elliott, Bradley T.; Herbert, Peter; Sculthorpe, Nicholas; Grace, Fergal M.; Stratton, Daniel; Hayes, Lawrence D.

Authors

Bradley T. Elliott

Peter Herbert

Nicholas Sculthorpe

Fergal M. Grace

Lawrence D. Hayes



Abstract

Lifelong exercise is associated with regulation of skeletal mass and function, reductions in frailty, and successful aging. Yet, the influence of exercise on myostatin and myostatin-interacting factors is relatively under examined in older males. Therefore, we investigated whether serum total myostatin, free myostatin, follistatin, and growth and differentiation factor 11 (GDF11) were altered following high-intensity interval training (HIIT) in a group of 13 lifelong sedentary (SED; 64 [6] years) and 11 lifelong exercising (LEX; 62 [6] years) older males. SED follistatin was moderately greater than LEX pre-HIIT (Cohen's d = 0.66), and was largely greater post-HIIT (Cohen's d = 1.22). The HIIT-induced increase in follistatin was large in SED (Cohen's d = 0.82) and absent in LEX (Cohen's d = 0.03). GDF11 was higher in LEX pre-HIIT (Cohen's d = 0.49) and post-HIIT (Cohen's d = 0.63) compared to SED. HIIT resulted in no change to GDF11 in LEX or SED (Cohen's d = 0.00– 0.03). Peak power output and GDF11 were correlated (r = 0.603), independent of grouping. Differences in GDF11 with lifelong exercise training, paired with the correlation between GDF11 and peak power output, suggested that GDF11 may be a relevant myostatin-interacting peptide to successful aging in humans, and strategies to maintain this need to be further explored.

Journal Article Type Article
Publication Date 2017-07
Journal Physiol Rep
Print ISSN 2051-817x
Electronic ISSN 2051-817X
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 5
Issue 13
Article Number e13343
Pages e13343
APA6 Citation Elliott, B. T., Herbert, P., Sculthorpe, N., Grace, F. M., Stratton, D., & Hayes, L. D. (2017). Lifelong exercise, but not short-term high-intensity interval training, increases GDF11, a marker of successful aging: a preliminary investigation. Physiological Reports, 5(13), e13343. doi:10.14814/phy2.13343
DOI https://doi.org/10.14814/phy2.13343
Keywords Aging, exercise, follistatin, GDF11, HIIT,; myostatin; Correspondence
Publisher URL https://physoc.onlinelibrary.wiley.com/doi/abs/10.14814/phy2.13343
Related Public URLs http://westminsterresearch.wmin.ac.uk/19281/
Copyright Statement © 2017 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Copyright Statement
© 2017 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.



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