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The effect of treatment of liraglutide on quality of life and depression in young obese women with PCOS and controls

Kahal, H; Kilpatrick, ES; Rigby, A; Coady, AM; Atkin, SL


H Kahal

ES Kilpatrick

A Rigby

AM Coady

SL Atkin


Polycystic ovary syndrome (PCOS) is associated with reduced quality of life (QoL), though the role of associated obesity is unclear. In this study we examined the effects of six months treatment with liraglutide, 1.8 mg od, on obesity, depression and QoL in young women with PCOS and obesity compared to age- and weight-matched controls. In a cross-sectional study, 36 women were recruited (19 PCOS, 17 controls), age 33.9 ± 6.7 vs. 33.5 ± 7.1 yr, and weight 102.1 ± 17.1 vs. 100.4 ± 15.1 kg, respectively. PCOS was diagnosed according to the Rotterdam criteria. Depression was measured using the Centre for Epidemiologic Studies Depression Scale (CES-D). QoL was measured using the World Health Organization QoL questionnaire (WHOQOL-BREF). At baseline there was no difference in QoL or CES-D scores between the two groups. At six months, weight was reduced by 3.0 ± 4.2 kg, p = .01, in the PCOS group and 3.8 ± 3.4 kg, p = .001, in controls. Psychological health improved in the PCOS group (percentage change 11.3%, p smaller than .02). Combining the two groups revealed significant improvement (p smaller than .05) in physical (82.6 ± 11.2 vs. 78.9 ± 13.6), psychological (62.4 ± 16.5 vs. 57.5 ± 16.4) and social health (76.6 ± 15.3 vs. 71 ± 16.8) components of the WHOQOL-BREF at six months. Weight loss is associated with an improvement in QoL; and when matched for age and obesity, PCOS was not independently associated with reduced QoL or depression.


Kahal, H., Kilpatrick, E., Rigby, A., Coady, A., & Atkin, S. (2019). The effect of treatment of liraglutide on quality of life and depression in young obese women with PCOS and controls. Gynecological Endocrinology, 35(2), 142-145.

Journal Article Type Article
Acceptance Date Jul 25, 2018
Online Publication Date Jan 1, 2019
Publication Date Jan 1, 2019
Deposit Date Jul 26, 2018
Publicly Available Date Jan 2, 2020
Print ISSN 0951-3590
Publisher Taylor & Francis
Peer Reviewed Peer Reviewed
Volume 35
Issue 2
Pages 142-145
Keywords PCOS; Liraglutide; Obesity; Quality of life; Depression
Public URL
Publisher URL
Copyright Statement ©2018 University of Hull


V3 Accepted PCOS Lir QoL Paper 18.07.2018 (77 Kb)

Copyright Statement
©2018 University of Hull

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