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Lifelong exercise, but not short-term high-intensity interval training, increases GDF11, a marker of successful aging: a preliminary investigation (2017)
Journal Article
Elliott, B. T., Herbert, P., Sculthorpe, N., Grace, F. M., Stratton, D., & Hayes, L. D. (2017). Lifelong exercise, but not short-term high-intensity interval training, increases GDF11, a marker of successful aging: a preliminary investigation. Physiological Reports, 5(13), e13343. doi:10.14814/phy2.13343

Lifelong exercise is associated with regulation of skeletal mass and function, reductions in frailty, and successful aging. Yet, the influence of exercise on myostatin and myostatin-interacting factors is relatively under examined in older males. The... Read More

Sigma-1 receptors modulate neonatal Nav1.5 ion channels in breast cancer cell lines (2016)
Journal Article
Aydar, E., Stratton, D., Fraser, S. P., Djamgoz, M. B., & Palmer, C. (2016). Sigma-1 receptors modulate neonatal Nav1.5 ion channels in breast cancer cell lines. European Biophysics Journal, 45(7), 671-683. doi:10.1007/s00249-016-1135-0

The main aim of this study was to investigate a possible functional connection between sigma-1 receptors and voltage-gated sodium channels (VGSCs) in human breast cancer cells. The hypothesis was that sigma-1 drugs could alter the metastatic properti... Read More

Inhibition of microvesiculation sensitizes prostate cancer cells to chemotherapy and reduces docetaxel dose required to limit tumor growth in vivo (2015)
Journal Article
Jorfi, S., Ansa-Addo, E. A., Kholia, S., Stratton, D., Valley, S., Lange, S., & Inal, J. (2015). Inhibition of microvesiculation sensitizes prostate cancer cells to chemotherapy and reduces docetaxel dose required to limit tumor growth in vivo. Scientific reports, 5(1), doi:10.1038/srep13006

Microvesicles shed from cells carry constituents of the cell cytoplasm, including, of importance in multidrug resistance to cancer chemotherapy, drugs that the tumor cell attempts to efflux. To see whether such drugs could be used at lower concentrat... Read More

Microvesicles released constitutively from prostate cancer cells differ biochemically and functionally to stimulated microvesicles released through sublytic C5b-9 (2015)
Journal Article
Stratton, D., Moore, C., Antwi-Baffour, S., Lange, S., & Inal, J. (2015). Microvesicles released constitutively from prostate cancer cells differ biochemically and functionally to stimulated microvesicles released through sublytic C5b-9. Biochemical and biophysical research communications, 460(3), 589-595. doi:10.1016/j.bbrc.2015.03.074

© 2015 Elsevier Inc. All rights reserved. We have classified microvesicles into two subtypes: larger MVs released upon stimulation of prostate cancer cells, sMVs, and smaller cMVs, released constitutively. cMVs are released as part of cell metabolism... Read More

Prostate cancer cells stimulated by calcium-mediated activation of protein kinase C undergo a refractory period before re-releasing calcium-bearing microvesicles (2015)
Journal Article
Stratton, D., Moore, C., Zheng, L., Lange, S., & Inal, J. (2015). Prostate cancer cells stimulated by calcium-mediated activation of protein kinase C undergo a refractory period before re-releasing calcium-bearing microvesicles. Biochemical and biophysical research communications, 460(3), 511-517. doi:10.1016/j.bbrc.2015.03.061

© 2015 Elsevier Inc.All rights reserved. MVs are released in response to several stress agents, in an attempt to prevent continued cellular damage. After an initial stimulus of prostate cancer cells with sublytic C5b-9 and activation of MV release th... Read More

Label-free real-time acoustic sensing of microvesicle release from prostate cancer (PC3) cells using a Quartz Crystal Microbalance (2014)
Journal Article
Stratton, D., Lange, S., Kholia, S., Jorfi, S., Antwi-Baffour, S., & Inal, J. (2014). Label-free real-time acoustic sensing of microvesicle release from prostate cancer (PC3) cells using a Quartz Crystal Microbalance. Biochemical and biophysical research communications, 453(3), 619-624. doi:10.1016/j.bbrc.2014.09.132

© 2014 Elsevier Inc. All rights reserved. Using a Quartz Crystal Microbalance with dissipation monitoring, QCM-D (label-free system) measuring changes in resonant frequency (Δf) that equate to mass deposited on a sensor, we showed the attachment, ove... Read More

Pulsed extremely low-frequency magnetic fields stimulate microvesicle release from human monocytic leukaemia cells (2012)
Journal Article
Stratton, D., Lange, S., & Inal, J. M. (2013). Pulsed extremely low-frequency magnetic fields stimulate microvesicle release from human monocytic leukaemia cells. Biochemical and biophysical research communications, 430(2), 470-475. doi:10.1016/j.bbrc.2012.12.012

Microvesicles are released from cell surfaces constitutively during early apoptosis or upon activation with various stimuli including sublytic membrane attack complex (MAC). This study shows that an alternating current, pulsed, extremely low-frequenc... Read More