All Outputs (375)

A single risk assessment for the most common diseases of ageing, developed and validated on 10 cohort studies (2024)
Journal Article
Huque, M. H., Kootar, S., Kiely, K. M., Anderson, C. S., van Boxtel, M., Brodaty, H., Sachdev, P. S., Carlson, M., Fitzpatrick, A. L., Whitmer, R. A., Kivipelto, M., Jorm, L., Köhler, S., Lautenschlager, N. T., Lopez, O. L., Shaw, J. E., Matthews, F. E., Peters, R., & Anstey, K. J. (2024). A single risk assessment for the most common diseases of ageing, developed and validated on 10 cohort studies. BMC medicine, 22(1), Article 501. https://doi.org/10.1186/s12916-024-03711-6

Background
We aimed to develop risk tools for dementia, stroke, myocardial infarction (MI), and diabetes, for adults aged ≥ 65 years using shared risk factors.
Methods
Data were obtained from 10 population-based cohorts (N = 41,755) with median fo... Read More about A single risk assessment for the most common diseases of ageing, developed and validated on 10 cohort studies.

Evaluating Models of the Ageing BOLD Response (2024)
Journal Article
Henson, R. N., Olszowy, W., Tsvetanov, K. A., Yadav, P. S., Tyler, L. K., Brayne, C., Bullmore, E. T., Calder, A. C., Cusack, R., Dalgleish, T., Duncan, J., Matthews, F. E., Marslen-Wilson, W. D., Rowe, J. B., Shafto, M. A., Campbell, K., Cheung, T., Davis, S., Geerligs, L., Kievit, R., …Zeidman, P. (2024). Evaluating Models of the Ageing BOLD Response. Human Brain Mapping, 45(15), Article e70043. https://doi.org/10.1002/hbm.70043

Neural activity cannot be directly observed using fMRI; rather it must be inferred from the hemodynamic responses that neural activity causes. Solving this inverse problem is made possible through the use of forward models, which generate predicted h... Read More about Evaluating Models of the Ageing BOLD Response.

The association between frailty, care receipt and unmet need for care with the risk of hospital admissions (2024)
Journal Article
Maharani, A., Sinclair, D. R., Clegg, A., Hanratty, B., Nazroo, J., Tampubolon, G., Todd, C., Wittenberg, R., O’Neill, T. W., & Matthews, F. E. (2024). The association between frailty, care receipt and unmet need for care with the risk of hospital admissions. PLoS ONE, 19(9), Article e0306858. https://doi.org/10.1371/journal.pone.0306858

Background Frailty is characterised by a decline in physical, cognitive, energy, and health reserves and is linked to greater functional dependency and higher social care utilisation. However, the relationship between receiving care, or receiving ins... Read More about The association between frailty, care receipt and unmet need for care with the risk of hospital admissions.

Changes in prevalence and incidence of dementia and risk factors for dementia: an analysis from cohort studies (2024)
Journal Article
Mukadam, N., Wolters, F. J., Walsh, S., Wallace, L., Brayne, C., Matthews, F. E., Sacuiu, S., Skoog, I., Seshadri, S., Beiser, A., Ghosh, S., & Livingston, G. (2024). Changes in prevalence and incidence of dementia and risk factors for dementia: an analysis from cohort studies. The Lancet. Public Health, 9(7), e443-e460. https://doi.org/10.1016/S2468-2667%2824%2900120-8

Background: Some cohort studies have reported a decline in dementia prevalence and incidence over time, although these findings have not been consistent across studies. We reviewed evidence on changes in dementia prevalence and incidence over time us... Read More about Changes in prevalence and incidence of dementia and risk factors for dementia: an analysis from cohort studies.

Differences in trajectories of quality of life according to type of dementia: 6-year longitudinal findings from the IDEAL programme (2024)
Journal Article
Martyr, A., Gamble, L. D., Hunt, A., Quinn, C., Morris, R. G., Henderson, C., Allan, L., Opdebeeck, C., Charlwood, C., Jones, R. W., Pentecost, C., Kopelman, M. D., Thom, J. M., Matthews, F. E., & Clare, L. (2024). Differences in trajectories of quality of life according to type of dementia: 6-year longitudinal findings from the IDEAL programme. BMC medicine, 22(1), Article 265. https://doi.org/10.1186/s12916-024-03492-y

Background: People with different types of dementia may have distinct symptoms and experiences that affect their quality of life. This study investigated whether quality of life varied across types of dementia and over time. Methods: The participants... Read More about Differences in trajectories of quality of life according to type of dementia: 6-year longitudinal findings from the IDEAL programme.

Living Alone With Mild-to-Moderate Dementia Over a Two-Year Period: Longitudinal Findings From the IDEAL Cohort (2024)
Journal Article
Clare, L., Gamble, L. D., Martyr, A., Henderson, C., Knapp, M., & Matthews, F. E. (2024). Living Alone With Mild-to-Moderate Dementia Over a Two-Year Period: Longitudinal Findings From the IDEAL Cohort. American Journal of Geriatric Psychiatry, 32(11), 1309-1321. https://doi.org/10.1016/j.jagp.2024.05.012

Objectives: To compare the experiences of people with dementia living alone or with others and how these may change over two years. Design: We analysed longitudinal data from three assessment waves, one year apart, in the British IDEAL cohort. Settin... Read More about Living Alone With Mild-to-Moderate Dementia Over a Two-Year Period: Longitudinal Findings From the IDEAL Cohort.

The longitudinal associations between ambient air pollution exposure and dementia in the UK: results from the cognitive function and ageing study II and Wales (2024)
Journal Article
Wu, Y. T., Kitwiroon, N., Beevers, S., Barratt, B., Brayne, C., Cerin, E., …Matthews, F. (2024). The longitudinal associations between ambient air pollution exposure and dementia in the UK: results from the cognitive function and ageing study II and Wales. BMC public health, 24(1), Article 1233. https://doi.org/10.1186/s12889-024-18723-3

Background: Air pollution has been recognised as a potential risk factor for dementia. Yet recent epidemiological research shows mixed evidence. The aim of this study is to investigate the longitudinal associations between ambient air pollution expos... Read More about The longitudinal associations between ambient air pollution exposure and dementia in the UK: results from the cognitive function and ageing study II and Wales.

Associations between multimorbidity and neuropathology in dementia: Consideration of functional cognitive disorders, psychiatric illness and dementia mimics (2024)
Journal Article
Hamilton, C. A., Matthews, F. E., Attems, J., Donaghy, P. C., Erskine, D., Taylor, J. P., & Thomas, A. J. (2024). Associations between multimorbidity and neuropathology in dementia: Consideration of functional cognitive disorders, psychiatric illness and dementia mimics. British Journal of Psychiatry, 224(6), 237-244. https://doi.org/10.1192/bjp.2024.25

Background Multimorbidity, the presence of two or more health conditions, has been identified as a possible risk factor for clinical dementia. It is unclear whether this is due to worsening brain health and underlying neuropathology, or other factors... Read More about Associations between multimorbidity and neuropathology in dementia: Consideration of functional cognitive disorders, psychiatric illness and dementia mimics.

The Microglial Transcriptome of Age-Associated Deep Subcortical White Matter Lesions Suggests a Neuroprotective Response to Blood–Brain Barrier Dysfunction (2024)
Journal Article
Almansouri, T., Waller, R., Wharton, S. B., Heath, P. R., Matthews, F. E., Brayne, C., van Eeden, F., & Simpson, J. E. (2024). The Microglial Transcriptome of Age-Associated Deep Subcortical White Matter Lesions Suggests a Neuroprotective Response to Blood–Brain Barrier Dysfunction. International Journal of Molecular Sciences, 25(8), Article 4445. https://doi.org/10.3390/ijms25084445

Age-associated deep-subcortical white matter lesions (DSCLs) are an independent risk factor for dementia, displaying high levels of CD68+ microglia. This study aimed to characterize the transcriptomic profile of microglia in DSCLs and surrounding rad... Read More about The Microglial Transcriptome of Age-Associated Deep Subcortical White Matter Lesions Suggests a Neuroprotective Response to Blood–Brain Barrier Dysfunction.

Health conditions in spousal caregivers of people with dementia and their relationships with stress, caregiving experiences, and social networks: longitudinal findings from the IDEAL programme (2024)
Journal Article
Sabatini, S., Martyr, A., Hunt, A., Gamble, L. D., Matthews, F. E., Thom, J. M., …Clare, L. (2024). Health conditions in spousal caregivers of people with dementia and their relationships with stress, caregiving experiences, and social networks: longitudinal findings from the IDEAL programme. BMC Geriatrics, 24(1), Article 171. https://doi.org/10.1186/s12877-024-04707-w

Objectives: Longitudinal evidence documenting health conditions in spousal caregivers of people with dementia and whether these influence caregivers’ outcomes is scarce. This study explores type and number of health conditions over two years in careg... Read More about Health conditions in spousal caregivers of people with dementia and their relationships with stress, caregiving experiences, and social networks: longitudinal findings from the IDEAL programme.

Relationships of Brain Cholesterol and Cholesterol Biosynthetic Enzymes to Alzheimer’s Pathology and Dementia in the CFAS Population-Derived Neuropathology Cohort (2024)
Journal Article
Mistry, H., Richardson, C. D., Higginbottom, A., Ashford, B., Ahamed, S. U., Moore, Z., …Wharton, S. B. (2024). Relationships of Brain Cholesterol and Cholesterol Biosynthetic Enzymes to Alzheimer’s Pathology and Dementia in the CFAS Population-Derived Neuropathology Cohort. Neuroscience Research, 204, Article 22-33. https://doi.org/10.1016/j.neures.2024.01.003

Altered cholesterol metabolism is implicated in brain ageing and Alzheimer's disease. We examined whether key genes regulating cholesterol metabolism and levels of brain cholesterol are altered in dementia and Alzheimer's disease neuropathological ch... Read More about Relationships of Brain Cholesterol and Cholesterol Biosynthetic Enzymes to Alzheimer’s Pathology and Dementia in the CFAS Population-Derived Neuropathology Cohort.

Comorbid health conditions and their impact on social isolation, loneliness, quality of life, and well-being in people with dementia: longitudinal findings from the IDEAL programme (2024)
Journal Article
Sabatini, S., Martyr, A., Hunt, A., Gamble, L. D., Matthews, F. E., Thom, J. M., Jones, R. W., Allan, L., Knapp, M., Victor, C., Pentecost, C., Rusted, J. M., Morris, R. G., & Clare, L. (2024). Comorbid health conditions and their impact on social isolation, loneliness, quality of life, and well-being in people with dementia: longitudinal findings from the IDEAL programme. BMC Geriatrics, 24(1), Article 23. https://doi.org/10.1186/s12877-023-04601-x

Background: Most people with dementia have multiple health conditions. This study explores (1) number and type of health condition(s) in people with dementia overall and in relation to age, sex, dementia type, and cognition; (2) change in number of h... Read More about Comorbid health conditions and their impact on social isolation, loneliness, quality of life, and well-being in people with dementia: longitudinal findings from the IDEAL programme.

Identifying predictors of transition to a care home for people with dementia: findings from the IDEAL programme (2024)
Journal Article
Sabatini, S., Martyr, A., Gamble, L. D., Matthews, F. E., Thom, J. M., Henderson, C., Allan, L., Pentecost, C., Quinn, C., Hunt, A., & Clare, L. (2024). Identifying predictors of transition to a care home for people with dementia: findings from the IDEAL programme. Aging and Mental Health, https://doi.org/10.1080/13607863.2024.2383367

Objectives: This study investigates factors associated with the person with dementia and the caregiver to identify those associated with an increased risk of transition to a care home. Method: IDEAL data were collected at baseline and at 12- and 24-m... Read More about Identifying predictors of transition to a care home for people with dementia: findings from the IDEAL programme.

Living well with dementia: An exploratory matched analysis of minority ethnic and white people with dementia and carers participating in the IDEAL programme (2024)
Journal Article
Victor, C. R., Gamble, L. D., Pentecost, C., Quinn, C., Charlwood, C., Matthews, F. E., & Clare, L. (2024). Living well with dementia: An exploratory matched analysis of minority ethnic and white people with dementia and carers participating in the IDEAL programme. International journal of geriatric psychiatry, 39(1), Article e6048. https://doi.org/10.1002/gps.6048

Objectives: The increasing heterogeneity of the population of older people is reflected in an increasing number of people with dementia and carers drawn from minority ethnic groups. Data from the IDEAL study are used to compare indices of ‘living wel... Read More about Living well with dementia: An exploratory matched analysis of minority ethnic and white people with dementia and carers participating in the IDEAL programme.

Dyadic perspectives on loneliness and social isolation among people with dementia and spousal carers: findings from the IDEAL programme (2023)
Journal Article
Rippon, I., Victor, C. R., Martyr, A., Matthews, F. E., Quinn, C., Rusted, J. M., Jones, R. W., Collins, R., van Horik, J., Pentecost, C., Allan, L., & Clare, L. (in press). Dyadic perspectives on loneliness and social isolation among people with dementia and spousal carers: findings from the IDEAL programme. Aging and Mental Health, 1-9. https://doi.org/10.1080/13607863.2023.2286618

Objectives: This study aims to investigate the impact of self and partner experiences of loneliness and social isolation on life satisfaction in people with dementia and their spousal carers. Methods: We used data from 1042 dementia caregiving dyads... Read More about Dyadic perspectives on loneliness and social isolation among people with dementia and spousal carers: findings from the IDEAL programme.

Study protocol for development and validation of a single tool to assess risks of stroke, diabetes mellitus, myocardial infarction and dementia: DemNCD-Risk (2023)
Journal Article
Kootar, S., Huque, M. H., Kiely, K. M., Anderson, C. S., Jorm, L., Kivipelto, M., …Anstey, K. J. (2023). Study protocol for development and validation of a single tool to assess risks of stroke, diabetes mellitus, myocardial infarction and dementia: DemNCD-Risk. BMJ open, 13(9), Article e076860. https://doi.org/10.1136/bmjopen-2023-076860

Introduction Current efforts to reduce dementia focus on prevention and risk reduction by targeting modifiable risk factors. As dementia and cardiometabolic non-communicable diseases (NCDs) share risk factors, a single risk-estimating tool for dement... Read More about Study protocol for development and validation of a single tool to assess risks of stroke, diabetes mellitus, myocardial infarction and dementia: DemNCD-Risk.

Trajectories of cognitive and perceived functional decline in people with dementia: Findings from the IDEAL programme (2023)
Journal Article
Martyr, A., Ravi, M., Gamble, L. D., Morris, R. G., Rusted, J. M., Pentecost, C., …Clare, L. (2024). Trajectories of cognitive and perceived functional decline in people with dementia: Findings from the IDEAL programme. Alzheimer's & dementia, 20(1), 410-420. https://doi.org/10.1002/alz.13448

INTRODUCTION: Impaired cognition and instrumental activities of daily living (iADL) are key diagnostic features of dementia; however, few studies have compared trajectories of cognition and iADL. METHODS: Participants from the IDEAL study comprised 1... Read More about Trajectories of cognitive and perceived functional decline in people with dementia: Findings from the IDEAL programme.

Insights into the pathological basis of dementia from population-based neuropathology studies (2023)
Journal Article
Wharton, S. B., Simpson, J. E., Ince, P. G., Richardson, C. D., Merrick, R., Matthews, F. E., & Brayne, C. (2023). Insights into the pathological basis of dementia from population-based neuropathology studies. Neuropathology and Applied Neurobiology, 49(4), Article e12923. https://doi.org/10.1111/nan.12923

The epidemiological neuropathology perspective of population and community-based studies allows unbiased assessment of the prevalence of various pathologies and their relationships to late-life dementia. In addition, this approach provides complement... Read More about Insights into the pathological basis of dementia from population-based neuropathology studies.

Predicting cognitive decline using neuropsychiatric symptoms in prodromal Lewy body dementia: A longitudinal study (2023)
Journal Article
Wright, L. M., Donaghy, P. C., Burn, D. J., Taylor, J. P., O'Brien, J. T., Yarnall, A. J., …Lawson, R. A. (2023). Predicting cognitive decline using neuropsychiatric symptoms in prodromal Lewy body dementia: A longitudinal study. Parkinsonism and Related Disorders, 113, Article 105762. https://doi.org/10.1016/j.parkreldis.2023.105762

Introduction: Neuropsychiatric symptoms (NPS) in Lewy body dementias (LBD) occur frequently and early in disease progression. Such symptoms are associated with worse quality of life, caregiver burden and functional limitations. Limited evidence exist... Read More about Predicting cognitive decline using neuropsychiatric symptoms in prodromal Lewy body dementia: A longitudinal study.

Time trends in neuropathology give clues to dementia risk reduction (2023)
Journal Article
Merrick, R., & Matthews, F. E. (2023). Time trends in neuropathology give clues to dementia risk reduction. Nature Reviews Neurology, 19(7), 389-390. https://doi.org/10.1038/s41582-023-00812-3

A new study sheds light on the declining incidence of dementia by examining trends in neuropathology over time in autopsy results from two large US cohorts. Although the prevalence of neurodegenerative pathologies remained similar, a reduction in the... Read More about Time trends in neuropathology give clues to dementia risk reduction.