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Statins and ischaemia reperfusion injury: a molecular biological review (2010)
Journal Article
N.A. Abdul Rahman, M., & C. Chetter, I. (2010). Statins and ischaemia reperfusion injury: a molecular biological review. Current Vascular Pharmacology, 8(6), 831-835. https://doi.org/10.2174/157016110793563780

The 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase inhibitors (statins) are a class of drug used to lower low-density lipoprotein (LDL) levels. However, in recent years, statins have been shown to possess a pleiotropic effect beyond its choleste... Read More about Statins and ischaemia reperfusion injury: a molecular biological review.

A randomized placebo controlled trial of the effect of preoperative statin use on matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in areas of low and peak wall stress in patients undergoing elective open repair of abdominal ao (2010)
Journal Article
Rahman, M. A., Khan, J. A., Mazari, F. A. K., Mockford, K., McCollum, P. T., & Chetter, I. (2011). A randomized placebo controlled trial of the effect of preoperative statin use on matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in areas of low and peak wall stress in patients undergoing elective open repair of abdominal ao. Annals of vascular surgery, 25(1), 32-38. https://doi.org/10.1016/j.avsg.2010.06.006

BackgroundA double-blind, randomized controlled trial was carried out to study the effects of statins on matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) in areas of peak and low abdominal aortic aneurysm (A... Read More about A randomized placebo controlled trial of the effect of preoperative statin use on matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in areas of low and peak wall stress in patients undergoing elective open repair of abdominal ao.

Computerized dynamic posturography in the objective assessment of balance in patients with intermittent claudication (2010)
Journal Article
Mockford, K. A., Mazari, F. A. K., Jordan, A. R., Vanicek, N., Chetter, I. C., & Coughlin, P. A. (2011). Computerized dynamic posturography in the objective assessment of balance in patients with intermittent claudication. Annals of vascular surgery, 25(2), 182-190. https://doi.org/10.1016/j.avsg.2010.07.021

One-third of all elderly patients fall each year and impaired balance has been recognized as a specific risk factor. Intermittent claudication is common among the elderly population, affecting approximately 5% of the population over the age of 50. Th... Read More about Computerized dynamic posturography in the objective assessment of balance in patients with intermittent claudication.

Hull early walking aid for rehabilitation of transtibial amputees - randomized controlled trial (HEART) (2010)
Journal Article
Mazari, F. A. K., Mockford, K., Vanicek, N., Barnett, C., Khan, J. A., Brown, B., …Chetter, I. C. (2010). Hull early walking aid for rehabilitation of transtibial amputees - randomized controlled trial (HEART). Journal of vascular surgery, 52(6), 1564-1571. https://doi.org/10.1016/j.jvs.2010.07.006

Purpose: To compare articulated and nonarticulated early walking aids (EWAs) for clinical and quality-of-life outcomes in transtibial amputees. Methods: Patients undergoing lower limb amputation in a tertiary-care vascular surgical unit were screened... Read More about Hull early walking aid for rehabilitation of transtibial amputees - randomized controlled trial (HEART).

Randomized clinical trial of tranexamic acid-free fibrin sealant during vascular surgical procedures (2010)
Journal Article
Chalmers, R. T. A., Darling, R. C., Wingard, J. T., Chetter, I., Cutler, B., Kern, J. A., & Hart, J. C. (2010). Randomized clinical trial of tranexamic acid-free fibrin sealant during vascular surgical procedures. British journal of surgery, 97(12), 1784-1789. https://doi.org/10.1002/bjs.7235

Background: This study evaluated the safety and haemostatic effectiveness of a fibrin sealant (EVICELTM Fibrin Sealant (Human)) during vascular surgery. Methods: This prospective randomized controlled trial compared the haemostatic effectiveness of f... Read More about Randomized clinical trial of tranexamic acid-free fibrin sealant during vascular surgical procedures.

Kinematic adaptations to ischemic pain in claudicants during continuous walking (2010)
Journal Article
Mockford, K. A., Vanicek, N., Jordan, A., Chetter, I. C., & Coughlin, P. A. (2010). Kinematic adaptations to ischemic pain in claudicants during continuous walking. Gait and Posture, 32(3), 395-399. https://doi.org/10.1016/j.gaitpost.2010.06.021

Intermittent claudication has been associated with impaired gait and balance. The study aim was to compare gait adaptations over time between claudicants classified with good versus poor balance. Kinematic data were collected from 24 claudicants duri... Read More about Kinematic adaptations to ischemic pain in claudicants during continuous walking.

Prospective observational study for comparison of use of Short Form-36 dimension scores and patient responses for derivation of preference based Short Form-6D index to calculate of quality adjusted life years (QALYs) for economic analyses in patients with (2010)
Journal Article
Mazari, F., Abdul Rahman, H., Khan, J., Mockford, K., McCollum, P., & Chetter, I. (2010). Prospective observational study for comparison of use of Short Form-36 dimension scores and patient responses for derivation of preference based Short Form-6D index to calculate of quality adjusted life years (QALYs) for economic analyses in patients with. British journal of surgery, 97,

Energy delivery during 810 nm endovenous laser ablation of varicose veins and post-procedural morbidity (2010)
Journal Article
Carradice, D., Mazari, F. A., Mekako, A., Hatfield, J., Allgar, V., & Chetter, I. (2010). Energy delivery during 810 nm endovenous laser ablation of varicose veins and post-procedural morbidity. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 40(3), 393-398. https://doi.org/10.1016/j.ejvs.2010.04.010

Aim: The durability of occlusion post endovenous laser therapy (EVLT) for varicose veins is linked to the magnitude of energy delivered to the vein and consequently increasing amounts of energy are employed. The aim of this study is to establish whet... Read More about Energy delivery during 810 nm endovenous laser ablation of varicose veins and post-procedural morbidity.

Cost utility analysis of a randomised control trial of percutaneous transluminal angioplasty (PTA), supervised exercise programme (SEP) and combined treatment (PTA plus SEP) for patients with intermittent claudication (IC) due to femoropopliteal disease (2010)
Journal Article
Mazari, F., Abdul Rahman, H., Khan, J., McCollum, P., Gulati, S., Mehta, T., & Chetter, I. (2010). Cost utility analysis of a randomised control trial of percutaneous transluminal angioplasty (PTA), supervised exercise programme (SEP) and combined treatment (PTA plus SEP) for patients with intermittent claudication (IC) due to femoropopliteal disease. British journal of surgery, 97, 42829

Randomized clinical trial of co-amoxiclav versus no antibiotic prophylaxis in varicose vein surgery (2009)
Journal Article
Mekako, A. I., Chetter, I. C., Coughlin, P. A., Hatfield, J., & McCollum, P. T. (2010). Randomized clinical trial of co-amoxiclav versus no antibiotic prophylaxis in varicose vein surgery. British journal of surgery, 97(1), 29-36. https://doi.org/10.1002/bjs.6849

Background: Wound infection rates of up to 16 per cent are reported following varicose vein surgery and the value of antibiotic prophylaxis in clean surgery remains unclear. Methods: Some 443 patients undergoing varicose vein surgery randomly receive... Read More about Randomized clinical trial of co-amoxiclav versus no antibiotic prophylaxis in varicose vein surgery.

Early outcomes from a randomized, controlled trial of supervised exercise, angioplasty, and combined therapy in intermittent claudication (2009)
Journal Article
Mazari, F., Gulati, S., Rahman, M., Lee, H., Mehta, T., McCollum, P., & Chetter, I. (2010). Early outcomes from a randomized, controlled trial of supervised exercise, angioplasty, and combined therapy in intermittent claudication. Annals of vascular surgery, 24(1), 69-79. https://doi.org/10.1016/j.avsg.2009.07.005

Background To compare angioplasty (PTA), supervised exercise (SEP) and PTA + SEP in the treatment of intermittent claudication (IC) due to femoropopliteal disease Methods Over a 6-year period, 178 patients (108 men; median age, 70 years) with fe... Read More about Early outcomes from a randomized, controlled trial of supervised exercise, angioplasty, and combined therapy in intermittent claudication.

Randomized clinical trial of concomitant or sequential phlebectomy after endovenous laser therapy for varicose veins (2009)
Journal Article
Carradice, D., Mekako, A. I., Hatfield, J., & Chetter, I. C. (2009). Randomized clinical trial of concomitant or sequential phlebectomy after endovenous laser therapy for varicose veins. British journal of surgery, 96(4), 369-375. https://doi.org/10.1002/bjs.6556

Background: The management of residual varicosities following endovenous laser therapy (EVLT) for varicose veins is contentious. Ambulatory phlebectomy may be performed concomitantly with the initial EVLT, or sequentially as a secondary procedure. Th... Read More about Randomized clinical trial of concomitant or sequential phlebectomy after endovenous laser therapy for varicose veins.

Laser venous interventions (2009)
Journal Article
Carradice, D., & Chetter, I. (2009). Laser venous interventions. Vascular Disease Management, 6(2), 41 - 46

Kinematic gait adaptations in unilateral transtibial amputees during rehabilitation (2009)
Journal Article
Barnett, C., Vanicek, N., Polman, R., Hancock, A., Brown, B., Smith, L., & Chetter, I. (2009). Kinematic gait adaptations in unilateral transtibial amputees during rehabilitation. Prosthetics and orthotics international, 33(2), 135-147. https://doi.org/10.1080/03093640902751762

Introduction: Physiotherapists routinely prescribe the use of two different early walking aids (EWAs) to individuals who have recently undergone unilateral transtibial amputation. No research to date has investigated the kinematic gait patterns of tr... Read More about Kinematic gait adaptations in unilateral transtibial amputees during rehabilitation.

General anaesthesia versus local anaesthesia for carotid surgery (GALA): a multicentre, randomised controlled trial (2008)
Journal Article
Chetter, I. (2008). General anaesthesia versus local anaesthesia for carotid surgery (GALA): a multicentre, randomised controlled trial. Lancet, 372(9656), 2132-2142. https://doi.org/10.1016/S0140-6736%2808%2961699-2

BackgroundThe effect of carotid endarterectomy in lowering the risk of stroke ipsilateral to severe atherosclerotic carotid-artery stenosis is offset by complications during or soon after surgery. We compared surgery under general anaesthesia with th... Read More about General anaesthesia versus local anaesthesia for carotid surgery (GALA): a multicentre, randomised controlled trial.

Quality of life in patients with lower limb ischemia; revised suggestions for analysis (2008)
Journal Article
Gulati, S., Coughlin, P. A., Hatfield, J., & Chetter, I. C. (2009). Quality of life in patients with lower limb ischemia; revised suggestions for analysis. Journal of vascular surgery, 49(1), 122-126. https://doi.org/10.1016/j.jvs.2008.08.011

Background: Quality of life (QoL) is a crucial outcome measure in patients with lower limb ischemia (LLI). The Short Form 36 (SF36) has been proposed as the gold standard instrument for generic QoL analysis in patients with LLI. The Short Form 8 (SF8... Read More about Quality of life in patients with lower limb ischemia; revised suggestions for analysis.