All Outputs (10)

Procoagulant tumor microvesicles attach to endothelial cells on biochips under microfluidic flow (2019)
Journal Article
Algarni, A., Greenman, J., & Madden, L. A. (2019). Procoagulant tumor microvesicles attach to endothelial cells on biochips under microfluidic flow. Biomicrofluidics, 13(6), Article 064124. https://doi.org/10.1063/1.5123462

Tumor patients are at a high risk of venous thromboembolism (VTE), and the mechanism by which this occurs may involve tumor-derived microvesicles (MVs). Previously, it has been shown that tumor MVs become attached to endothelial cells in static condi... Read More about Procoagulant tumor microvesicles attach to endothelial cells on biochips under microfluidic flow.

Isolated tumour microparticles induce endothelial microparticle release in vitro (2019)
Journal Article
Faulkner, L. G., Alqarni, S., Maraveyas, A., & Madden, L. A. (2020). Isolated tumour microparticles induce endothelial microparticle release in vitro. Blood Coagulation and Fibrinolysis, 31(1), 35-42. https://doi.org/10.1097/MBC.0000000000000876

© 2019 Wolters Kluwer Health, Inc. All rights reserved. Cancer induces a hypercoagulable state, resulting in an increased risk of venous thromboembolism. One of the mechanisms driving this is tissue factor (TF) production by the tumour, released in s... Read More about Isolated tumour microparticles induce endothelial microparticle release in vitro.

Targeted removal of blood cancer cells from mixed cell populations by cell recognition with matching particle imprints (2019)
Journal Article
Das, A. A., Remaud, P., Medlock, J., Das, A. A. K., Allsup, D. J., Madden, L. A., Nees, D., Weldrick, P. J., & Paunov, V. N. (2019). Targeted removal of blood cancer cells from mixed cell populations by cell recognition with matching particle imprints. Materials Chemistry Frontiers, 4(1), 197-205. https://doi.org/10.1039/c9qm00531e

We report a new approach for separation of blood cancer cells from healthy white blood cells based on cell recognition by surface functionalised particle imprints. We prepared polymeric particle imprints from a layer of suspension of monodisperse PMM... Read More about Targeted removal of blood cancer cells from mixed cell populations by cell recognition with matching particle imprints.

Impaired heat shock protein 72 expression in women with polycystic ovary syndrome following a supervised exercise programme (2019)
Journal Article
Vince, R. V., Kirk, R. J., Aye, M. M., Atkin, S. L., & Madden, L. A. (2020). Impaired heat shock protein 72 expression in women with polycystic ovary syndrome following a supervised exercise programme. Cell Stress and Chaperones, 25(1), 73-80. https://doi.org/10.1007/s12192-019-01048-1

Induction of heat shock protein expression and the heat shock (stress) response are seen in exercise. This exercise-induced response is thought protective against cellular stress through the expression of heat shock proteins. The highly inducible hea... Read More about Impaired heat shock protein 72 expression in women with polycystic ovary syndrome following a supervised exercise programme.

Feasibility of a novel exercise prehabilitation programme in patients scheduled for elective colorectal surgery: a feasibility randomised controlled trial (2019)
Journal Article
Northgraves, M. J., Arunachalam, L., Madden, L. A., Marshall, P., Hartley, J. E., MacFie, J., & Vince, R. V. (2019). Feasibility of a novel exercise prehabilitation programme in patients scheduled for elective colorectal surgery: a feasibility randomised controlled trial. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, https://doi.org/10.1007/s00520-019-05098-0

© 2019, The Author(s). Background and objectives: To investigate the feasibility of delivering a functional exercise-based prehabilitation intervention and its effects on postoperative length of hospital stay, preoperative physical functioning and he... Read More about Feasibility of a novel exercise prehabilitation programme in patients scheduled for elective colorectal surgery: a feasibility randomised controlled trial.

Effect of home-based resistance training performed with or without a high-speed component in adults with severe obesity (2019)
Journal Article
Orange, S. T., Marshall, P., Madden, L. A., & Vince, R. V. (2020). Effect of home-based resistance training performed with or without a high-speed component in adults with severe obesity. Translational Sports Medicine, 3(1), 34-45. https://doi.org/10.1002/tsm2.115

The objectives of this study were to:(a) evaluate the effects of walking and home-based resistance training on function, strength, power, anthropometry, and quality of life (QoL) in adults with severe obesity, and (b) assess whether performing resist... Read More about Effect of home-based resistance training performed with or without a high-speed component in adults with severe obesity.

The CD105:CD106 microparticle ratio is CD106 dominant in polycystic ovary syndrome compared to type 2 diabetes and healthy subjects (2019)
Journal Article
Al-Qaissi, A., Alqarni, S., Javed, Z., Atkin, S. L., Sathyapalan, T., Vince, R., & Madden, L. A. (2019). The CD105:CD106 microparticle ratio is CD106 dominant in polycystic ovary syndrome compared to type 2 diabetes and healthy subjects. Endocrine, https://doi.org/10.1007/s12020-019-02059-9

© 2019, The Author(s). Background: A retrospective analysis was carried out from patients and controls during the past 5 years from a series of studies investigating endothelial microparticles (MP). Methods: In total, 319 samples from 207 individuals... Read More about The CD105:CD106 microparticle ratio is CD106 dominant in polycystic ovary syndrome compared to type 2 diabetes and healthy subjects.

Fabrication of Human Keratinocyte Cell Clusters for Skin Graft Applications by Templating Water-in-Water Pickering Emulsions (2019)
Journal Article
Celik, S., Dominici, S., Filby, B., Das, A., Madden, L. A., & Paunov, V. N. (2019). Fabrication of Human Keratinocyte Cell Clusters for Skin Graft Applications by Templating Water-in-Water Pickering Emulsions. Biomimetics, 4(3), Article 50. https://doi.org/10.3390/biomimetics4030050

Most current methods for the preparation of tissue spheroids require complex materials, involve tedious physical steps and are generally not scalable. We report a novel alternative, which is both inexpensive and up-scalable, to produce large quantiti... Read More about Fabrication of Human Keratinocyte Cell Clusters for Skin Graft Applications by Templating Water-in-Water Pickering Emulsions.

Bioimprint aided cell recognition and depletion of human leukemic HL60 cells from peripheral blood (2019)
Journal Article
Das, A. A., Medlock, J., Liang, H., Nees, D., Allsup, D. J., Madden, L. A., & Paunov, V. N. (2019). Bioimprint aided cell recognition and depletion of human leukemic HL60 cells from peripheral blood. Journal of Materials Chemistry B, 7(22), 3497-3504. https://doi.org/10.1039/c9tb00679f

We report a large scale preparation of bioimprints of layers of cultured human leukemic HL60 cells which can perform cell shape and size recognition from a mixture with peripheral blood mononuclear cells (PBMCs). We demonstrate that the bioimprint-ce... Read More about Bioimprint aided cell recognition and depletion of human leukemic HL60 cells from peripheral blood.

Circulating endothelial microparticles reduce in concentration following an exercise programme in women with polycystic ovary syndrome (2019)
Journal Article
Kirk, R. J., Madden, L. A., Peart, D. J., Aye, M. M., Atkin, S. L., & Vince, R. V. (2019). Circulating endothelial microparticles reduce in concentration following an exercise programme in women with polycystic ovary syndrome. Frontiers in endocrinology, 10(MAR), Article 200. https://doi.org/10.3389/fendo.2019.00200

Purpose: Endothelial dysfunction is a known comorbidity in women with polycystic ovary syndrome (PCOS). The aim was to assess if supervised, moderate intensity exercise could potentially impact markers of endothelial disruption; endothelial cell deri... Read More about Circulating endothelial microparticles reduce in concentration following an exercise programme in women with polycystic ovary syndrome.