All Outputs (137)

In Silico and invitro modelling of chronic wounds to improve our understanding of wound biomechanics and to test novel medical devices (2024)
Thesis
Hendon, A. C. In Silico and invitro modelling of chronic wounds to improve our understanding of wound biomechanics and to test novel medical devices. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4703110

Negative pressure wound therapy (NPWT) is a widely used system that aids the healing of chronic wounds through the application of sub-atmospheric pressure. The effectiveness of this method is widely recognised, however the mechanisms behind this are... Read More about In Silico and invitro modelling of chronic wounds to improve our understanding of wound biomechanics and to test novel medical devices.

Bioartificial scaffolds fabrication and their use for in vitro testing of wound healing devices (2023)
Thesis
Mandolini, N. Bioartificial scaffolds fabrication and their use for in vitro testing of wound healing devices. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4386661

In the last decades Negative Pressure Wound Therapy (NPWT) has shown its efficacy in wound healing, applying continuous or intermittent subatmospheric pressure to the wound surface by means of dressing systems. While there is general consen... Read More about Bioartificial scaffolds fabrication and their use for in vitro testing of wound healing devices.

Airflow rates and breathlessness recovery from submaximal exercise in healthy adults: prospective, randomised, cross-over study (2023)
Journal Article
Brew, A., O'Beirne, S., Johnson, M. J., Ramsenthaler, C., Watson, P., Rubini, P. A., Fagan, M. J., Swan, F., & Simpson, A. (online). Airflow rates and breathlessness recovery from submaximal exercise in healthy adults: prospective, randomised, cross-over study. BMJ supportive & palliative care, https://doi.org/10.1136/spcare-2023-004309

Objectives: Facial airflow from a hand-held fan may reduce breathlessness severity and hasten postexertion recovery. Data from randomised controlled trials are limited and the optimal airflow speed remains unknown. We aimed to determine the effect of... Read More about Airflow rates and breathlessness recovery from submaximal exercise in healthy adults: prospective, randomised, cross-over study.

Assessment of the mechanical role of cranial sutures in the mammalian skull: Computational biomechanical modelling of the rat skull (2023)
Journal Article
Sharp, A. C., Dutel, H., Watson, P. J., Gröning, F., Crumpton, N., Fagan, M. J., & Evans, S. E. (2023). Assessment of the mechanical role of cranial sutures in the mammalian skull: Computational biomechanical modelling of the rat skull. Journal of morphology, 284(3), Article e21555. https://doi.org/10.1002/jmor.21555

Cranial sutures are fibrocellular joints between the skull bones that are progressively replaced with bone throughout ontogeny, facilitating growth and cranial shape change. This transition from soft tissue to bone is reflected in the biomechanical p... Read More about Assessment of the mechanical role of cranial sutures in the mammalian skull: Computational biomechanical modelling of the rat skull.

Patient specific training: development of a CT-based mixed reality fibreoptic intubation simulator (2022)
Journal Article
Wright, D., Ma, X., Atkin, W., Wang, L., Fagan, M., & Wellbelove, Z. (2022). Patient specific training: development of a CT-based mixed reality fibreoptic intubation simulator. International Journal of Healthcare Simulation, 2(1), A86. https://doi.org/10.54531/QOJS8275

Fibreoptic intubation training has traditionally been performed using real fibreoptic scopes and manikins or improvised airway ‘boxes’, recently progressing to virtual reality training devices [1]. The latter are populated with computer generated ima... Read More about Patient specific training: development of a CT-based mixed reality fibreoptic intubation simulator.

Biomechanical evaluation of the unilateral crossbite on the asymmetrical development of the craniofacial complex. A mechano-morphological approach (2022)
Journal Article
Ortún-Terrazas, J., Fagan, M. J., Cegoñino, J., Illipronti-Filho, E., & del Palomar, A. P. (2022). Biomechanical evaluation of the unilateral crossbite on the asymmetrical development of the craniofacial complex. A mechano-morphological approach. Computer Methods and Programs in Biomedicine, 217, Article 106703. https://doi.org/10.1016/j.cmpb.2022.106703

Background and Objective: The occlusion effect on the craniofacial development is a controversial topic that has attracted the interest of many researchers but that remains unclear, mainly due to the difficulties on measure its mechanical response ex... Read More about Biomechanical evaluation of the unilateral crossbite on the asymmetrical development of the craniofacial complex. A mechano-morphological approach.

A hierarchical opportunistic screening model for osteoporosis using machine learning applied to clinical data and CT images (2022)
Journal Article
Liu, L., Si, M., Ma, H., Cong, M., Xu, Q., Sun, Q., …Ji, B. (2022). A hierarchical opportunistic screening model for osteoporosis using machine learning applied to clinical data and CT images. BMC Bioinformatics, 23, Article 63. https://doi.org/10.1186/s12859-022-04596-z

Background: Osteoporosis is a common metabolic skeletal disease and usually lacks obvious symptoms. Many individuals are not diagnosed until osteoporotic fractures occur. Bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA) i... Read More about A hierarchical opportunistic screening model for osteoporosis using machine learning applied to clinical data and CT images.

Modeling and control of anterior–posterior and medial–lateral sways in standing posture (2022)
Journal Article
Hou, M., Fagan, M., Vanicek, N., & Dobson, C. A. (2022). Modeling and control of anterior–posterior and medial–lateral sways in standing posture. Journal of biomechanics, 134, Article 110930. https://doi.org/10.1016/j.jbiomech.2021.110930

To study essential anterior–posterior and medial–lateral sways of the stance caused by rotational movements about the ankle and hip joints, a mathematical model is developed for the 3D postural kinematics and dynamics. The model is in the form of non... Read More about Modeling and control of anterior–posterior and medial–lateral sways in standing posture.

Assessments of bilateral asymmetry with application in human skull analysis (2021)
Journal Article
Hou, M., & Fagan, M. J. (2021). Assessments of bilateral asymmetry with application in human skull analysis. PLoS ONE, 16(10), Article e0258146. https://doi.org/10.1371/journal.pone.0258146

As a common feature, bilateral symmetry of biological forms is ubiquitous, but in fact rarely exact. In a setting of analytic geometry, bilateral symmetry is defined with respect to a point, line or plane, and the well-known notions of fluctuating as... Read More about Assessments of bilateral asymmetry with application in human skull analysis.

From micro to macroevolution: drivers of shape variation in an island radiation of Podarcis lizards (2021)
Journal Article
Taverne, M., Dutel, H., Fagan, M., Štambuk, A., Lisičić, D., Tadić, Z., …Herrel, A. (2021). From micro to macroevolution: drivers of shape variation in an island radiation of Podarcis lizards. Evolution, 75(11), 2685-2707. https://doi.org/10.1111/evo.14326

Phenotypictraits have been shown to evolve in response to variation in the environment. However, the evolutionary processes underlying the emergence of phenotypic diversity can typically only be understood at the population level. Consequently, how s... Read More about From micro to macroevolution: drivers of shape variation in an island radiation of Podarcis lizards.

Back to the bones: do muscle area assessment techniques predict functional evolution across a macroevolutionary radiation? (2021)
Journal Article
Bates, K. T., Wang, L., Dempsey, M., Broyde, S., Fagan, M. J., & Cox, P. G. (2021). Back to the bones: do muscle area assessment techniques predict functional evolution across a macroevolutionary radiation?. Interface, 18(180), Article 20210324. https://doi.org/10.1098/rsif.2021.0324

Measures of attachment or accommodation area on the skeleton are a popular means of rapidly generating estimates of muscle proportions and functional performance for use in large-scale macroevolutionary studies. Herein, we provide the first evaluatio... Read More about Back to the bones: do muscle area assessment techniques predict functional evolution across a macroevolutionary radiation?.

Computational biomechanical modelling of the rabbit cranium during mastication (2021)
Journal Article
Watson, P. J., Sharp, A. C., Choudhary, T., Fagan, M. J., Dutel, H., Evans, S. E., & Gröning, F. (2021). Computational biomechanical modelling of the rabbit cranium during mastication. Scientific reports, 11(1), https://doi.org/10.1038/s41598-021-92558-5

Although a functional relationship between bone structure and mastication has been shown in some regions of the rabbit skull, the biomechanics of the whole cranium during mastication have yet to be fully explored. In terms of cranial biomechanics, th... Read More about Computational biomechanical modelling of the rabbit cranium during mastication.

Regional patterning in tail vertebral form and function in chameleons (Chamaeleo calyptratus) (2021)
Journal Article
Luger, A. M., Watson, P. J., Dutel, H., Fagan, M. J., Van Hoorebeke, L., Herrel, A., & Adriaens, D. (2021). Regional patterning in tail vertebral form and function in chameleons (Chamaeleo calyptratus). Integrative and Comparative Biology, 61(2), 455-463. https://doi.org/10.1093/icb/icab125

Previous studies have focused on documenting shape variation in the caudal vertebrae in chameleons underlying prehensile tail function. The goal of this study was to test the impact of this variation on tail function using multibody dynamic analysis... Read More about Regional patterning in tail vertebral form and function in chameleons (Chamaeleo calyptratus).

Correction to: Evolutionary biomechanics: Hard tissues and soft evidence? (Proc. R. Soc. B (2021) 288 (20202809) DOI: 10.1098/rspb.2020.2809) (2021)
Journal Article
Broyde, S., Dempsey, M., Wang, L., Cox, P. G., Fagan, M., & Bates, K. T. (2021). Correction to: Evolutionary biomechanics: Hard tissues and soft evidence? (Proc. R. Soc. B (2021) 288 (20202809) DOI: 10.1098/rspb.2020.2809). Proceedings of the Royal Society B: Biological Sciences, 288(1950), Article 20202809. https://doi.org/10.1098/rspb.2021.0831

Further analysis of our finite element (FE) models, as part of ongoing work, has revealed a systematic error running through all 30 models in our original analysis. In all 30 FE models, the force magnitudes applied to represent maximum isometric cont... Read More about Correction to: Evolutionary biomechanics: Hard tissues and soft evidence? (Proc. R. Soc. B (2021) 288 (20202809) DOI: 10.1098/rspb.2020.2809).

Comparative cranial biomechanics in two lizard species: impact of variation in cranial design (2021)
Journal Article
Groning, F., Dutel, H., Gröning, F., Sharp, A. C., Watson, P. J., Herrel, A., Ross, C. F., Jones, M. E. H., Evans, S. E., & Fagan, M. J. (2021). Comparative cranial biomechanics in two lizard species: impact of variation in cranial design. The journal of experimental biology, 224(5), Article jeb.234831. https://doi.org/10.1242/jeb.234831

Cranial morphology in lepidosaurs is highly disparate and characterised by the frequent loss or reduction of bony elements. In varanids and geckos, the loss of the postorbital bar is associated with changes in skull shape, but the mechanical principl... Read More about Comparative cranial biomechanics in two lizard species: impact of variation in cranial design.

Evolutionary biomechanics: hard tissues and soft evidence? (2021)
Journal Article
Broyde, S., Dempsey, M., Wang, L., Cox, P. G., Fagan, M., & Bates, K. T. (2021). Evolutionary biomechanics: hard tissues and soft evidence?. Proceedings of the Royal Society B: Biological Sciences, 288(1945), Article 20202809. https://doi.org/10.1098/rspb.2020.2809

Biomechanical modelling is a powerful tool for quantifying the evolution of functional performance in extinct animals to understand key anatomical innovations and selective pressures driving major evolutionary radiations. However, the fossil record i... Read More about Evolutionary biomechanics: hard tissues and soft evidence?.

The biomechanical role of the chondrocranium and the material properties of cartilage (2020)
Journal Article
Jones, M. E. H., Gröning, F., Aspden, R. M., Dutel, H., Sharp, A., Moazen, M., Fagan, M. J., & Evans, S. E. (2020). The biomechanical role of the chondrocranium and the material properties of cartilage. Vertebrate Zoology, 70(4), 699-715. https://doi.org/10.26049/VZ70-4-2020-10

The chondrocranium is the cartilage component of the vertebrate braincase. Among jawed vertebrates it varies greatly in structure, mineralisation, and in the extent to which it is replaced by bone during development. In mammals, birds, and some bony... Read More about The biomechanical role of the chondrocranium and the material properties of cartilage.

Mathematical modeling of canonical and non-canonical NF-κB pathways in TNF stimulation (2020)
Journal Article
Ji, B., Zhang, Y., Zhen, C., Fagan, M. J., & Yang, Q. (2020). Mathematical modeling of canonical and non-canonical NF-κB pathways in TNF stimulation. Computer Methods and Programs in Biomedicine, 196, Article 105677. https://doi.org/10.1016/j.cmpb.2020.105677

Background and objective: NF-κB can be activated by the canonical and non-canonical pathways. These two pathways interplay via the TRAF1|NIK complex after stimulation by TNF. However existing mathematical models of two pathways are inadequate. In thi... Read More about Mathematical modeling of canonical and non-canonical NF-κB pathways in TNF stimulation.

The influence of musculoskeletal forces on the growth of the prenatal cortex in the ilium: a finite element study (2020)
Journal Article
Watson, P. J., Fagan, M. J., & Dobson, C. A. (in press). The influence of musculoskeletal forces on the growth of the prenatal cortex in the ilium: a finite element study. Computer methods in biomechanics and biomedical engineering, https://doi.org/10.1080/10255842.2020.1777546

Remodelling and adaptation of bone within the pelvis is believed to be influenced by the mechanical strains generated during locomotion. Variation in the cortical bone thickness observed in the prenatal ilium has been linked to the musculoskeletal lo... Read More about The influence of musculoskeletal forces on the growth of the prenatal cortex in the ilium: a finite element study.

Towards an early 3D-diagnosis of craniofacial asymmetry by computing the accurate midplane: A PCA-based method (2020)
Journal Article
Ortún-Terrazas, J., Fagan, M. J., Cegoñino, J., Illipronti-Filho, E., & Pérez del Palomar, A. (2020). Towards an early 3D-diagnosis of craniofacial asymmetry by computing the accurate midplane: A PCA-based method. Computer Methods and Programs in Biomedicine, 191, Article 105397. https://doi.org/10.1016/j.cmpb.2020.105397

Background and objective: Craniofacial asymmetry is a common growth disorder often caused by unilateral chewing. Although an early orthodontic treatment would avoid surgical procedures later in life, the uncertainty of defining the accurate sagittal... Read More about Towards an early 3D-diagnosis of craniofacial asymmetry by computing the accurate midplane: A PCA-based method.