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All Outputs (34)

Environmental and financial cost of surgical-site infection by severity after lower limb vascular surgery (2025)
Journal Article
Lathan, R., Daysley, H., Ravindhran, B., Lim, A., Cutteridge, J., Sidapra, M., Long, J., Hitchman, L., Beltran-Alvarez, P., Carradice, D., Smith, G., & Chetter, I. (2025). Environmental and financial cost of surgical-site infection by severity after lower limb vascular surgery. BJS Open, 9(3), Article zraf015. https://doi.org/10.1093/bjsopen/zraf015

Background
There is sparse evidence of the relationship between environmental and financial costs of surgical-site infection. Identifying areas of high-cost burden would enable key targets for clinical interventions to aid in achieving the UK nation... Read More about Environmental and financial cost of surgical-site infection by severity after lower limb vascular surgery.

Social context prevents heat hormetic effects against mutagens during fish development (2025)
Journal Article
Feugere, L., Silva De Freitas, C., Bates, A., Storey, K. B., Beltran-Alvarez, P., & Wollenberg Valero, K. C. (online). Social context prevents heat hormetic effects against mutagens during fish development. FEBS Letters, https://doi.org/10.1002/1873-3468.70047

Since stress can be transmitted to congeners via social metabolites, it is paramount to understand how the social context of abiotic stress influences aquatic organisms' responses to global changes. Here, we integrated the transcriptomic and phenotyp... Read More about Social context prevents heat hormetic effects against mutagens during fish development.

Exploring the use of Arginine Methylation Inhibitors Against Brain Tumours in an ex vivo Perfusion System (2025)
Thesis
Barry, A. (2025). Exploring the use of Arginine Methylation Inhibitors Against Brain Tumours in an ex vivo Perfusion System. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/5133792

Glioblastoma (GBM) is the most common primary malignancy in the central nervous system and the most devastating, with a median survival of 18 months from diagnosis. The development of models to research and understand GBM tumourigenesis and progressi... Read More about Exploring the use of Arginine Methylation Inhibitors Against Brain Tumours in an ex vivo Perfusion System.

The Role of Environmentally Relevant Concentrations of SSRIs in Human Wound Healing (2025)
Thesis
Rodriguez-Barucg, Q. (2025). The Role of Environmentally Relevant Concentrations of SSRIs in Human Wound Healing. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/5126336

This thesis investigates the role of environmentally relevant concentrations of fluoxetine, a commonly prescribed selective serotonin reuptake inhibitor (SSRI), in wound healing. While SSRIs are effective in treating psychiatric conditions, their inc... Read More about The Role of Environmentally Relevant Concentrations of SSRIs in Human Wound Healing.

Environmental fluoxetine promotes skin cell proliferation and wound healing (2024)
Journal Article
Rodriguez-Barucg, Q., Garcia, A. A., Garcia-Merino, B., Akinmola, T., Okotie-Eboh, T., Francis, T., Bringas, E., Ortiz, I., Wade, M., Dowle, A., Joyce, D. A., Hardman, M. J., Wilkinson, H. N., & Beltran-Alvarez, P. (2024). Environmental fluoxetine promotes skin cell proliferation and wound healing. Environmental pollution, 362, Article 124952. https://doi.org/10.1016/j.envpol.2024.124952

This study investigates the effects of environmentally-relevant concentrations of fluoxetine (FLX, commercial name: Prozac) on wound healing. Pollution of water systems with pharmaceutical and personal care products, including antidepressants such as... Read More about Environmental fluoxetine promotes skin cell proliferation and wound healing.

Understanding the use of wood-burning stoves in the East Riding - a postnote (2024)
Report
Oresanya, T. O., Norfolk, K., Mullen, S., Taylor, J., Durham, G., & Beltran-Alvarez, P. Understanding the use of wood-burning stoves in the East Riding - a postnote. East Riding of Yorkshire Council

Opening paragraph:
Wood-burning is particularly common in the East Riding of Yorkshire. Wood-burning stoves are used by a higher percentage of households in the East Riding, compared to average use in England as a whole.
Wood burning can lead to po... Read More about Understanding the use of wood-burning stoves in the East Riding - a postnote.

Environmental factors influence cross-talk between a heat shock protein and an oxidative stress protein modification in the lizard Gallotia galloti (2024)
Journal Article
Gilbert, E., Žagar, A., López-Darias, M., Megía-Palma, R., Lister, K. A., Jones, M. D., Carretero, M. A., Serén, N., Beltran-Alvarez, P., & Wollenberg Valero, K. C. (2024). Environmental factors influence cross-talk between a heat shock protein and an oxidative stress protein modification in the lizard Gallotia galloti. PLoS ONE, 19(3 March), Article e0300111. https://doi.org/10.1371/journal.pone.0300111

Better understanding how organisms respond to their abiotic environment, especially at the biochemical level, is critical in predicting population trajectories under climate change. In this study, we measured constitutive stress biomarkers and protei... Read More about Environmental factors influence cross-talk between a heat shock protein and an oxidative stress protein modification in the lizard Gallotia galloti.

Investigating protein arginine methylation in platelets and hair (2023)
Thesis
Marsden, A. J. Investigating protein arginine methylation in platelets and hair. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4386508

Post-translational modification (PTM) of platelet proteins has long been known to have an effect on their ability to aggregate and form a thrombus. Arginine methylation (ArgMe) is catalysed by protein arginine methyltransferases (PRMTs) which... Read More about Investigating protein arginine methylation in platelets and hair.

Investigating the effects of arginine methylation inhibitors on microdissected brain tumour biopsies maintained in a miniaturised perfusion system (2023)
Journal Article
Barry, A., Samuel, S. F., Hosni, I., Moursi, A., Feugere, L., Sennett, C. J., Deepak, S., Achawal, S., Rajaraman, C., Iles, A., Wollenberg Valero, K. C., Scott, I. S., Green, V., Stead, L. F., Greenman, J., Wade, M. A., & Beltran-Alvarez, P. (2023). Investigating the effects of arginine methylation inhibitors on microdissected brain tumour biopsies maintained in a miniaturised perfusion system. Lab on a chip, 23(11), 2664-2682. https://doi.org/10.1039/d3lc00204g

Arginine methylation is a post-translational modification that consists of the transfer of one or two methyl (CH3) groups to arginine residues in proteins. Several types of arginine methylation occur, namely monomethylation, symmetric dimethylation a... Read More about Investigating the effects of arginine methylation inhibitors on microdissected brain tumour biopsies maintained in a miniaturised perfusion system.

Heat induces multiomic and phenotypic stress propagation in zebrafish embryos (2023)
Journal Article
Feugere, L., Bates, A., Emagbetere, T., Chapman, E., Malcolm, L., Bulmer, K., Hardege, J., Beltran-Alvarez, P., & Wollenberg Valero, K. C. (2023). Heat induces multiomic and phenotypic stress propagation in zebrafish embryos. PNAS Nexus, 2(5), Article pgad137. https://doi.org/10.1093/pnasnexus/pgad137

Heat alters biology from molecular to ecological levels, but may also have unknown indirect effects. This includes the concept that animals exposed to abiotic stress can induce stress in naive receivers. Here, we provide a comprehensive picture of th... Read More about Heat induces multiomic and phenotypic stress propagation in zebrafish embryos.

The language of abiotic stress in aquatic animals : molecular characterisation of stress metabolite-mediated stress communication (2022)
Thesis
Feugère, L. The language of abiotic stress in aquatic animals : molecular characterisation of stress metabolite-mediated stress communication. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4311814

It is well established that aquatic animals inform their neighbours of predation risk through chemical cues. In this thesis, I tested the hypothesis that stress propagation is a widespread mechanism also activated by abiotic stressors – such as those... Read More about The language of abiotic stress in aquatic animals : molecular characterisation of stress metabolite-mediated stress communication.

The Epigenetic Regulatory Protein CBX2 Promotes mTORC1 Signalling and Inhibits DREAM Complex Activity to Drive Breast Cancer Cell Growth (2022)
Journal Article
Bilton, L. J., Warren, C., Humphries, R. M., Kalsi, S., Waters, E., Francis, T., Dobrowinski, W., Beltran-Alvarez, P., & Wade, M. A. (2022). The Epigenetic Regulatory Protein CBX2 Promotes mTORC1 Signalling and Inhibits DREAM Complex Activity to Drive Breast Cancer Cell Growth. Cancers, 14(14), Article 3491. https://doi.org/10.3390/cancers14143491

Chromobox 2 (CBX2) is a chromatin-binding component of polycomb repressive complex 1, which causes gene silencing. CBX2 expression is elevated in triple-negative breast cancer (TNBC), for which there are few therapeutic options. Here, we aimed to inv... Read More about The Epigenetic Regulatory Protein CBX2 Promotes mTORC1 Signalling and Inhibits DREAM Complex Activity to Drive Breast Cancer Cell Growth.

Functional genomics of abiotic environmental adaptation in lacertid lizards and other vertebrates (2021)
Journal Article
Wollenberg Valero, K. C., Garcia-Porta, J., Irisarri, I., Feugere, L., Bates, A., Kirchhof, S., Jovanovic Glavas, O., Pafilis, P., Samuel, S. F., Müller, J., Vences, M., Turner, A. P., Beltran-Alvarez, P., & Storey, K. B. (in press). Functional genomics of abiotic environmental adaptation in lacertid lizards and other vertebrates. The journal of animal ecology, https://doi.org/10.1111/1365-2656.13617

Understanding the genomic basis of adaptation to different abiotic environments is important in the context of climate change and resulting short-term environmental fluctuations. Using functional and comparative genomics approaches, we here investiga... Read More about Functional genomics of abiotic environmental adaptation in lacertid lizards and other vertebrates.

Thermal stress induces a positive phenotypic and molecular feedback loop in zebrafish embryos (2021)
Journal Article
Feugere, L., Wollenberg Valero, K. C., Scott, V., Rodriguez-Barucg, Q., & Beltran-Alvarez, P. (2021). Thermal stress induces a positive phenotypic and molecular feedback loop in zebrafish embryos. Journal of Thermal Biology, 102, Article 103114. https://doi.org/10.1016/j.jtherbio.2021.103114

Aquatic organisms must cope with both rising and rapidly changing temperatures. These thermal changes can affect numerous traits, from molecular to ecological scales. Biotic stressors are already known to induce the release of chemical cues which tri... Read More about Thermal stress induces a positive phenotypic and molecular feedback loop in zebrafish embryos.

Inhibition of arginine methylation impairs platelet function (2021)
Journal Article
Marsden, A. J., Riley, D. R. J., Barry, A., Khalil, J. S., Guinn, B. A., Kemp, N. T., Rivero, F., & Beltran-Alvarez, P. (in press). Inhibition of arginine methylation impairs platelet function. ACS Pharmacology & Translational Science, https://doi.org/10.1021/acsptsci.1c00135

Protein arginine methyltransferases (PRMTs) catalyze the transfer of methyl groups to arginine residues in proteins. PRMT inhibitors are novel, promising drugs against cancer that are currently in clinical trials, which include oral administration of... Read More about Inhibition of arginine methylation impairs platelet function.

Love is in the hair: arginine methylation of human hair proteins as novel cardiovascular biomarkers (2021)
Journal Article
Marsden, A. J., Riley, D. R., Birkett, S., Rodriguez-Barucg, Q., Guinn, B. A., Carroll, S., Ingle, L., Sathyapalan, T., & Beltran-Alvarez, P. (in press). Love is in the hair: arginine methylation of human hair proteins as novel cardiovascular biomarkers. Amino acids, https://doi.org/10.1007/s00726-021-03024-5

Cardiovascular disease is the major cause of death worldwide. Extensive cardiovascular biomarkers are available using blood tests but very few, if any, investigations have described non-invasive tests for cardiovascular biomarkers based on readily av... Read More about Love is in the hair: arginine methylation of human hair proteins as novel cardiovascular biomarkers.

Investigating the role of arginine methylation in glioblastoma using biomicrofluidics (2021)
Thesis
Samuel, S. F. Investigating the role of arginine methylation in glioblastoma using biomicrofluidics. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4223865

Despite intense research, the prognosis of patients with glioblastoma (GBM) remains extremely poor, with a median survival of 1.5 years after diagnosis. The need for new therapeutic options is therefore a vital step towards securing a better outlook... Read More about Investigating the role of arginine methylation in glioblastoma using biomicrofluidics.

Arginine methylation: the promise of a ‘silver bullet’ for brain tumours? (2021)
Journal Article
Samuel, S. F., Barry, A., Greenman, J., & Beltran-Alvarez, P. (2021). Arginine methylation: the promise of a ‘silver bullet’ for brain tumours?. Amino acids, 53(4), 489-506. https://doi.org/10.1007/s00726-020-02937-x

Despite intense research efforts, our pharmaceutical repertoire against high-grade brain tumours has not been able to increase patient survival for a decade and life expectancy remains at less than 16months after diagnosis, on average. Inhibitors of... Read More about Arginine methylation: the promise of a ‘silver bullet’ for brain tumours?.

The inhibitory subunit of cardiac troponin (cTnI) is modified by arginine methylation in the human heart (2019)
Journal Article
Onwuli, D. O., Samuel, S., Sfyri, P., Welham, K., Goddard, M., Abu-Omar, Y., Loubani, M., Rivero, F., Matsakas, A., Benoit, D. M., Wade, M., Greenman, J., & Beltran-Alvarez, P. (2019). The inhibitory subunit of cardiac troponin (cTnI) is modified by arginine methylation in the human heart. International journal of cardiology, 282, 76-80. https://doi.org/10.1016/j.ijcard.2019.01.102

Background
The inhibitory subunit of cardiac troponin (cTnI) is a gold standard cardiac biomarker and also an essential protein in cardiomyocyte excitation-contraction coupling. The interactions of cTnI with other proteins are fine-tuned by post-tra... Read More about The inhibitory subunit of cardiac troponin (cTnI) is modified by arginine methylation in the human heart.

Inhibiting arginine methylation as a tool to investigate cross-talk with methylation and acetylation post-translational modifications in a glioblastoma cell line (2018)
Journal Article
Samuel, S. F., Marsden, A. J., Deepak, S., Rivero, F., Greenman, J., & Beltran-Alvarez, P. (2018). Inhibiting arginine methylation as a tool to investigate cross-talk with methylation and acetylation post-translational modifications in a glioblastoma cell line. Proteomes, 6(4), Article 44. https://doi.org/10.3390/proteomes6040044

Glioblastomas (GBM) are the most common grade 4 brain tumours; patients have very poor prognosis with an average survival of 15 months after diagnosis. Novel research lines have begun to explore aberrant protein arginine methylation (ArgMe) as a poss... Read More about Inhibiting arginine methylation as a tool to investigate cross-talk with methylation and acetylation post-translational modifications in a glioblastoma cell line.