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Interaction of suppressor of cytokine signalling 3 with cavin-1 links SOCS3 function and cavin-1 stability (2018)
Journal Article
Williams, J. J., Alotaiq, N., Mullen, W., Burchmore, R., Liu, L., Baillie, G. S., …Palmer, T. M. (2018). Interaction of suppressor of cytokine signalling 3 with cavin-1 links SOCS3 function and cavin-1 stability. Nature communications, 9(1), doi:10.1038/s41467-017-02585-y

Effective suppression of JAK–STAT signalling by the inducible inhibitor “suppressor of cytokine signalling 3” (SOCS3) is essential for limiting signalling from cytokine receptors. Here we show that cavin-1, a component of caveolae, is a functionally... Read More

Protein kinase C phosphorylates AMP-Activated protein kinase α1 Ser487 (2016)
Journal Article
Heathcote, H. R., Mancini, S. J., Strembitska, A., Jamal, K., Reihill, J. A., Palmer, T. M., …Salt, I. P. (2016). Protein kinase C phosphorylates AMP-Activated protein kinase α1 Ser487. Biochemical Journal, 473(24), 4681-4697. doi:10.1042/BCJ20160211

The key metabolic regulator, AMP-activated protein kinase (AMPK), is reported to be down-regulated in metabolic disorders, but the mechanisms are poorly characterised. Recent studies have identified phosphorylation of the AMPKα1/α2 catalytic subunit... Read More

The future of EPAC-targeted therapies: Agonism versus antagonism (2015)
Journal Article
Parnell, E., Palmer, T. M., & Yarwood, S. J. (2015). The future of EPAC-targeted therapies: Agonism versus antagonism. Trends in Pharmacological Sciences, 36(4), 203-214. doi:10.1016/j.tips.2015.02.003

Pharmaceutical manipulation of cAMP levels exerts beneficial effects through the regulation of the exchange protein activated by cAMP (EPAC) and protein kinase A (PKA) signalling routes. Recent attention has turned to the specific regulation of EPAC... Read More