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PCSK6 and Survival in Idiopathic Pulmonary Fibrosis (2023)
Journal Article
Oldham, J. M., Allen, R. J., Lorenzo-Salazar, J. M., Molyneaux, P. L., Ma, S. F., Joseph, C., Kim, J. S., Guillen-Guio, B., Hernández-Beeftink, T., Kropski, J. A., Huang, Y., Lee, C. T., Adegunsoye, A., Pugashetti, J. V., Linderholm, A. L., Vo, V., Strek, M. E., Jou, J., Muñoz-Barrera, A., Rubio-Rodriguez, L. A., …Noth, I. (2023). PCSK6 and Survival in Idiopathic Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine, 207(11), 1515-1524. https://doi.org/10.1164/rccm.202205-0845OC

Rationale: Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by limited treatment options and high mortality. A better understanding of the molecular drivers of IPF progression is needed. Objectives: To identify and validate... Read More about PCSK6 and Survival in Idiopathic Pulmonary Fibrosis.

Serum transthyretin and aminotransferases are associated with lean mass in people with coronary heart disease: Further insights from the CARE-CR study (2023)
Journal Article
James, E., Goodall, S., Nichols, S., Walker, K., Carroll, S., O’Doherty, A. F., & Ingle, L. (2023). Serum transthyretin and aminotransferases are associated with lean mass in people with coronary heart disease: Further insights from the CARE-CR study. Frontiers in Medicine, 10, Article 1094733. https://doi.org/10.3389/fmed.2023.1094733

Background: Low muscle mass disproportionately affects people with coronary heart disease compared to healthy controls but is under-researched and insufficiently treated. Inflammation, poor nutrition, and neural decline might contribute to low muscle... Read More about Serum transthyretin and aminotransferases are associated with lean mass in people with coronary heart disease: Further insights from the CARE-CR study.

Modulation of transient receptor potential (TRP) channels by plant derived substances used in over-the-counter cough and cold remedies (2023)
Journal Article
Stinson, R. J., Morice, A. H., & Sadofsky, L. R. (2023). Modulation of transient receptor potential (TRP) channels by plant derived substances used in over-the-counter cough and cold remedies. Respiratory Research, 24(1), Article 45. https://doi.org/10.1186/s12931-023-02347-z

Background: Upper respiratory tract infections (URTIs) impact all age groups and have a significant economic and social burden on society, worldwide. Most URTIs are mild and self-limiting, but due to the wide range of possible causative agents, inclu... Read More about Modulation of transient receptor potential (TRP) channels by plant derived substances used in over-the-counter cough and cold remedies.

High-intensity interval training in cardiac rehabilitation: a multi-centre randomized controlled trial (2023)
Journal Article
McGregor, G., Powell, R., Begg, B., Birkett, S. T., Nichols, S., Ennis, S., McGuire, S., Prosser, J., Fiassam, O., Hee, S. W., Hamborg, T., Banerjee, P., Hartfiel, N., Charles, J. M., Edwards, R. T., Drane, A., Ali, D., Osman, F., He, H., Lachlan, T., …Shave, R. (2023). High-intensity interval training in cardiac rehabilitation: a multi-centre randomized controlled trial. European Journal of Preventive Cardiology, 30(9), 745-755. https://doi.org/10.1093/eurjpc/zwad039

BACKGROUND: There is a lack of international consensus regarding the prescription of high-intensity interval training (HIIT) for people with coronary artery disease (CAD) attending cardiac rehabilitation (CR). AIMS: To assess the clinical effectivene... Read More about High-intensity interval training in cardiac rehabilitation: a multi-centre randomized controlled trial.

Modulatory properties of curcumin in cancer: A narrative review on the role of interferons (2023)
Journal Article
Chamani, S., Moossavi, M., Naghizadeh, A., Abbasifard, M., Kesharwani, P., Sathyapalan, T., & Sahebkar, A. (online). Modulatory properties of curcumin in cancer: A narrative review on the role of interferons. Phytotherapy Research, https://doi.org/10.1002/ptr.7734

The immune network is an effective network of cell types and chemical compounds established to maintain the body's homeostasis from foreign threats and to prevent the risk of a wide range of diseases; hence, its proper functioning and balance are ess... Read More about Modulatory properties of curcumin in cancer: A narrative review on the role of interferons.

Women and maternity care providers experiences of planned home birth in Northern Ireland: A descriptive survey (2023)
Journal Article
Gillen, P., Bamidele, O., & Healy, M. (2023). Women and maternity care providers experiences of planned home birth in Northern Ireland: A descriptive survey. Women and Birth, 36(4), e412-e420. https://doi.org/10.1016/j.wombi.2023.01.005

Background: Where a woman gives birth impacts both her postnatal outcomes and experiences. However, for women who plan home birth in Northern Ireland, their experiences and that of their maternity care providers are rarely sought. Aim: This study exa... Read More about Women and maternity care providers experiences of planned home birth in Northern Ireland: A descriptive survey.

Validation of the HULL Score clinical prediction rule for unsuspected pulmonary embolism in ambulatory cancer patients (2023)
Journal Article
Haque, F., Ryde, J., Broughton, L., Huang, C., Sethi, S., Stephens, A., Pillai, A., Mirza, S., Brown, V., Avery, G., Bozas, G., & Maraveyas, A. (2023). Validation of the HULL Score clinical prediction rule for unsuspected pulmonary embolism in ambulatory cancer patients. ERJ Open Research, 9(3), Article 00651-2022. https://doi.org/10.1183/23120541.00651-2022

Background Clinical prediction rules (CPRs) developed to predict adverse outcomes of suspected pulmonary embolism (PE) and facilitate outpatient management have limitations in discriminating outcomes for ambulatory cancer patients with unsuspected PE... Read More about Validation of the HULL Score clinical prediction rule for unsuspected pulmonary embolism in ambulatory cancer patients.

The Skin Microbiome: Current Landscape and Future Opportunities (2023)
Journal Article
Smythe, P., & Wilkinson, H. N. (2023). The Skin Microbiome: Current Landscape and Future Opportunities. International Journal of Molecular Sciences, 24(4), Article 3950. https://doi.org/10.3390/ijms24043950

Our skin is the largest organ of the body, serving as an important barrier against the harsh extrinsic environment. Alongside preventing desiccation, chemical damage and hypothermia, this barrier protects the body from invading pathogens through a so... Read More about The Skin Microbiome: Current Landscape and Future Opportunities.

Telemedicine in addictions: Feasibility randomised controlled trial (2023)
Journal Article
Mayet, S., Gledhill, A., McCaw, I., Hashmani, Z., Drozdova, Z., Arshad, S., Shahbaz, S., Huang, C., & Phillips, T. (2023). Telemedicine in addictions: Feasibility randomised controlled trial. Heroin Addiction and Related Clinical Problems, 25(3), 27-36

Background. Opioid dependence is high risk. Opioid agonist treatment (OAT) improves outcomes and reduces deaths. Nonattendance at addiction specialist prescribers who monitor OAT worsens outcomes. Telemedicine has been shown to improve attendance wit... Read More about Telemedicine in addictions: Feasibility randomised controlled trial.

Curcumin-piperine co-supplementation and human health: A comprehensive review of preclinical and clinical studies (2023)
Journal Article
Heidari, H., Bagherniya, M., Majeed, M., Sathyapalan, T., Jamialahmadi, T., & Sahebkar, A. (online). Curcumin-piperine co-supplementation and human health: A comprehensive review of preclinical and clinical studies. Phytotherapy Research, https://doi.org/10.1002/ptr.7737

Curcumin is extracted from the rhizomes Curcuma longa L. It is known for its anti-inflammatory and anti-oxidant activities. Despite its safety and potential for use against various diseases, curcumin's utility is restricted due to its low oral bioava... Read More about Curcumin-piperine co-supplementation and human health: A comprehensive review of preclinical and clinical studies.

Impact of the Covid-19 pandemic on neuropsychiatric symptoms and antipsychotic prescribing for people with dementia in nursing home settings (2023)
Journal Article
McDermid, J., Ballard, C., Khan, Z., Aarsland, D., Fox, C., Fossey, J., Clare, L., Moniz-Cook, E., Soto-Martin, M., Sweetnam, A., Mills, K., Cummings, J., & Corbett, A. (2023). Impact of the Covid-19 pandemic on neuropsychiatric symptoms and antipsychotic prescribing for people with dementia in nursing home settings. International journal of geriatric psychiatry, 38(1), Article e5878. https://doi.org/10.1002/gps.5878

Objectives: This study aimed to determine the impact of the Covid-19 pandemic on neuropsychiatric symptoms and antipsychotic use in people with dementia living in nursing homes. Methods: This was a comparative analysis of baseline data from two large... Read More about Impact of the Covid-19 pandemic on neuropsychiatric symptoms and antipsychotic prescribing for people with dementia in nursing home settings.

Is the uptake, engagement, and effectiveness of exclusively mobile interventions for the promotion of weight-related behaviors equal for all? A systematic review (2023)
Journal Article
Szinay, D., Forbes, C. C., Busse, H., DeSmet, A., Smit, E. S., & König, L. M. (in press). Is the uptake, engagement, and effectiveness of exclusively mobile interventions for the promotion of weight-related behaviors equal for all? A systematic review. Obesity Reviews, Article e13542. https://doi.org/10.1111/obr.13542

Mobile health interventions are promising behavior change tools. However, there is a concern that they may benefit some populations less than others and thus widen inequalities in health. This systematic review investigated differences in uptake of,... Read More about Is the uptake, engagement, and effectiveness of exclusively mobile interventions for the promotion of weight-related behaviors equal for all? A systematic review.

Antitussive efficacy of the current treatment protocol for refractory chronic cough: our real-world experience in a retrospective cohort study (2023)
Journal Article
Zhang, M., Morice, A. H., Si, F., Zhang, L., Chen, Q., Wang, S., Zhu, Y., Xu, X., Yu, L., & Qiu, Z. (2023). Antitussive efficacy of the current treatment protocol for refractory chronic cough: our real-world experience in a retrospective cohort study. Therapeutic Advances in Respiratory Disease, 17, https://doi.org/10.1177/17534666231167716

BACKGROUND: The management of refractory chronic cough (RCC) is a great challenge. Neuromodulators have long been used for RCC with imperfect efficacy. OBJECTIVES: We summarized the outcomes of the current treatments used at our specialist cough clin... Read More about Antitussive efficacy of the current treatment protocol for refractory chronic cough: our real-world experience in a retrospective cohort study.

Complex-order PID controller design for enhanced blood-glucose regulation in Type-I diabetes patients (2023)
Journal Article
Saleem, O., & Iqbal, J. (2023). Complex-order PID controller design for enhanced blood-glucose regulation in Type-I diabetes patients. Measurement and Control, https://doi.org/10.1177/00202940231189504

Type-I Diabetes (TID) is a chronic autoimmune disease that elevates the glucose levels in the patient’s bloodstream. This paper formulates a fractional complex-order Proportional-Integral-Derivative (PID) control strategy for robust Blood Glucose (BG... Read More about Complex-order PID controller design for enhanced blood-glucose regulation in Type-I diabetes patients.

Expert Views on Medical Involvement in the Swiss Assisted Dying Practice: “We Want to Have Our Cake and Eat It Too”? (2023)
Journal Article
Nyquist, C., Cohen-Almagor, R., & Kim, S. Y. H. (2023). Expert Views on Medical Involvement in the Swiss Assisted Dying Practice: “We Want to Have Our Cake and Eat It Too”?. AJOB Empirical Bioethics, https://doi.org/10.1080/23294515.2023.2232796

Background: Most jurisdictions that allow euthanasia and assisted suicide (AS) regulate it through the medical profession. However, the extent and nature of how medicine should be involved are debated. Swiss AS practice is unusual in that it is manag... Read More about Expert Views on Medical Involvement in the Swiss Assisted Dying Practice: “We Want to Have Our Cake and Eat It Too”?.

Nebulised interferon-β1a (SNG001) in hospitalised COVID-19: SPRINTER phase III study (2022)
Journal Article
Monk, P. D., Brookes, J. L., Tear, V. J., Batten, T. N., Mankowski, M., Adzic-Vukicevic, T., Crooks, M. G., Dosanjh, D. P., Kraft, M., Brightling, C. E., Gabbay, F. J., Holgate, S. T., Djukanovic, R., & Wilkinson, T. M. (2023). Nebulised interferon-β1a (SNG001) in hospitalised COVID-19: SPRINTER phase III study. ERJ Open Research, 9(2), Article 00605-2022. https://doi.org/10.1183/23120541.00605-2022

Background Despite the availability of vaccines and therapies, patients are being hospitalised with coronavirus disease 2019 (COVID-19). Interferon (IFN)-β is a naturally occurring protein that stimulates host immune responses against most viruses, i... Read More about Nebulised interferon-β1a (SNG001) in hospitalised COVID-19: SPRINTER phase III study.

Embedding new technology into clinical ultrasound practice: Is role extension for sonographers the key to improving patient pathways? (2022)
Journal Article
Parker, P., Edwards, H., Twiddy, M., Whybrow, P., & Rigby, A. (2022). Embedding new technology into clinical ultrasound practice: Is role extension for sonographers the key to improving patient pathways?. Ultrasound, 31(2), 84-90. https://doi.org/10.1177/1742271X221139210

Introduction: MicroUS is a new imaging technique that may have potential to reliably monitor prostate disease and therefore release capacity in MRI departments. Firstly, however, it is essential to identify which healthcare staff may be suitable to l... Read More about Embedding new technology into clinical ultrasound practice: Is role extension for sonographers the key to improving patient pathways?.

Classical and alternate complement factor overexpression in non-obese weight matched women with polycystic ovary syndrome does not correlate with vitamin D (2022)
Journal Article
Moin, A. S. M., Sathyapalan, T., Butler, A. E., & Atkin, S. L. (2022). Classical and alternate complement factor overexpression in non-obese weight matched women with polycystic ovary syndrome does not correlate with vitamin D. Frontiers in endocrinology, 13, Article 935750. https://doi.org/10.3389/fendo.2022.935750

Introduction: Women with polycystic ovary syndrome (PCOS) exhibit complement factor expression changes that may be obesity-driven rather than an intrinsic facet of PCOS; furthermore, complement changes have been associated with vitamin D deficiency,... Read More about Classical and alternate complement factor overexpression in non-obese weight matched women with polycystic ovary syndrome does not correlate with vitamin D.