All Outputs (414)

Thermal performance of a controllable pavement solar collector prototype with configuration flexibility (2022)
Journal Article
Ghalandari, T., Baetens, R., Verhaert, I., SNM Nasir, D., Van den bergh, W., & Vuye, C. (2022). Thermal performance of a controllable pavement solar collector prototype with configuration flexibility. Applied energy, 313, Article 118908. https://doi.org/10.1016/j.apenergy.2022.118908

Solar energy harvesting as a renewable and sustainable energy source has been widely investigated in recent years across engineering fields. The use of Pavement Solar Collectors (PSC) can lead to clean energy production, an increase in road safety, p... Read More about Thermal performance of a controllable pavement solar collector prototype with configuration flexibility.

Identification of difluorinated curcumin molecular targets linked to traumatic brain injury pathophysiology (2022)
Journal Article
Sahebkar, A., Sathyapalan, T., Guest, P. C., & Barreto, G. E. (2022). Identification of difluorinated curcumin molecular targets linked to traumatic brain injury pathophysiology. Biomedicine and Pharmacotherapy, 148, Article 112770. https://doi.org/10.1016/j.biopha.2022.112770

Traumatic brain injury (TBI) affects approximately 50% of the world population at some point in their lifetime. To date, there are no effective treatments as most of the damage occurs due to secondary effects through a variety of pathophysiological p... Read More about Identification of difluorinated curcumin molecular targets linked to traumatic brain injury pathophysiology.

Symptom burden and lived experiences of patients, caregivers and healthcare professionals on the management of malignant bowel obstruction: A qualitative systematic review (2022)
Journal Article
Baddeley, E., Mann, M., Bravington, A., Johnson, M. J., Currow, D., Murtagh, F. E., Boland, E., Obita, G., Oliver, A., Seddon, K., Nelson, A., Boland, J. W., & Noble, S. (in press). Symptom burden and lived experiences of patients, caregivers and healthcare professionals on the management of malignant bowel obstruction: A qualitative systematic review. Palliative medicine, https://doi.org/10.1177/02692163221081331

Background: Malignant bowel obstruction occurs in up to 50% of people with advanced ovarian and 15% of people with gastrointestinal cancers. Evaluation and comparison of interventions to manage symptoms are hampered by inconsistent evaluations of eff... Read More about Symptom burden and lived experiences of patients, caregivers and healthcare professionals on the management of malignant bowel obstruction: A qualitative systematic review.

Treatment of chronic cough: P2X3 receptor antagonists and beyond (2022)
Journal Article
Sykes, D. L., Zhang, M., & Morice, A. H. (2022). Treatment of chronic cough: P2X3 receptor antagonists and beyond. Pharmacology and Therapeutics, 237, Article 108166. https://doi.org/10.1016/j.pharmthera.2022.108166

For years chronic cough (CC) has presented an enormous physical, psychological, and social burden on those who experience it, with no approved pharmacological therapies to assuage their symptoms. With our improved understanding of the pathophysiologi... Read More about Treatment of chronic cough: P2X3 receptor antagonists and beyond.

Anti-Proliferative Potential of Fluorinated Curcumin Analogues: Experimental and Computational Analysis and Review of the Literature (2022)
Journal Article
Hatamipour, M., Hadizadeh, F., Jaafari, M. R., Khashyarmanesh, Z., Sathyapalan, T., & Sahebkar, A. (2022). Anti-Proliferative Potential of Fluorinated Curcumin Analogues: Experimental and Computational Analysis and Review of the Literature. Current medicinal chemistry, 29(8), 1459-1471. https://doi.org/10.2174/0929867328666210910141316

BACKGROUND: Curcuminoids, flavoring, and coloring agents in food have potent antioxidant, anti-tumor activity, and anti-inflammatory effects. However, they are rapidly metabolized to lesser active metabolites. Therefore, various studies have been con... Read More about Anti-Proliferative Potential of Fluorinated Curcumin Analogues: Experimental and Computational Analysis and Review of the Literature.

A cucurbit[6]uril-carbon dot system: a potentially new bioimaging agent. (2022)
Journal Article
Zhang, S., Tian, Y., Liu, M., Hong-Meng, T., Li, C. R., Zeng, X., Xiao, X., & Redshaw, C. (2022). A cucurbit[6]uril-carbon dot system: a potentially new bioimaging agent. Materials Chemistry Frontiers, 6, 973-980. https://doi.org/10.1039/d2qm00022a

We report novel cucurbit[6]uril (Q[6])/carbon quantum dots (CQDs) prepared by solvothermal and nitrogen doped methods. The m-Q[6]-CQDs have been characterized by FTIR, XRD and X-ray photoelectron spectroscopy. The obtained m-Q[6]-CQDs exhibit good wa... Read More about A cucurbit[6]uril-carbon dot system: a potentially new bioimaging agent..

The Predictive Role of Parathyroid Hormone for Nonalcoholic Fatty Liver Disease following Bariatric Surgery (2022)
Journal Article
Jamialahmadi, T., Nematy, M., Abdalla, M., Jangjoo, A., Goshayeshi, L., Kroh, M., Moallem, S. A., Abbasifard, M., Sathyapalan, T., & Sahebkar, A. (2022). The Predictive Role of Parathyroid Hormone for Nonalcoholic Fatty Liver Disease following Bariatric Surgery. Journal of Nutrition and Metabolism, 2022, Article 7319742. https://doi.org/10.1155/2022/7319742

Background. Morbid obesity is frequently complicated by chronic liver diseases, including nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), and fibrosis. Parathyroid hormone (PTH) is found to be elevated in morbid obesity... Read More about The Predictive Role of Parathyroid Hormone for Nonalcoholic Fatty Liver Disease following Bariatric Surgery.

COVID-19: Impact on Pediatric Palliative Care (2022)
Journal Article
Scott, H. M., Coombes, L., Braybrook, D., Roach, A., Harðardóttir, D., Bristowe, K., Ellis-Smith, C., Higginson, I., Gao, W., Bluebond-Langner, M., Farsides, B., Murtagh, F. E., Fraser, L. K., & Harding, R. (in press). COVID-19: Impact on Pediatric Palliative Care. Journal of pain and symptom management, https://doi.org/10.1016/j.jpainsymman.2022.02.330

Context: Children and young people with life-limiting or life-threatening conditions and their families are potentially vulnerable during COVID-19 lockdowns due to pre-existing high clinical support needs and social participation limitations. Objecti... Read More about COVID-19: Impact on Pediatric Palliative Care.

Acute aerobic exercise-conditioned serum reduces colon cancer cell proliferation in vitro through interleukin-6-induced regulation of DNA damage (2022)
Journal Article
Orange, S. T., Jordan, A. R., Odell, A., Kavanagh, O., Hicks, K. M., Eaglen, T., Todryk, S., & Saxton, J. M. (2022). Acute aerobic exercise-conditioned serum reduces colon cancer cell proliferation in vitro through interleukin-6-induced regulation of DNA damage. International journal of cancer. Journal international du cancer, 151(2), 265-274. https://doi.org/10.1002/ijc.33982

Epidemiological evidence shows that regular physical activity is associated with reduced risk of primary and recurrent colon cancer. However, the underlying mechanisms of action are poorly understood. We evaluated the effects of stimulating a human c... Read More about Acute aerobic exercise-conditioned serum reduces colon cancer cell proliferation in vitro through interleukin-6-induced regulation of DNA damage.

The prognostic significance of serum interferon-gamma (IFN-γ) in hormonally dependent breast cancer (2022)
Journal Article
Todorović-Raković, N., Milovanović, J., Greenman, J., & Radulovic, M. (2022). The prognostic significance of serum interferon-gamma (IFN-γ) in hormonally dependent breast cancer. Cytokine, 152, Article 155836. https://doi.org/10.1016/j.cyto.2022.155836

Background: Interferon-γ (IFN-γ) is a pleiotropic immunomodulatory cytokine. Because of its contradictory and even dualistic roles in malignancies, its potential as a biomarker remains to be unraveled. Aim: To evaluate the prognostic significance of... Read More about The prognostic significance of serum interferon-gamma (IFN-γ) in hormonally dependent breast cancer.

Diagnostic and Prognostic Protein Biomarkers of β-Cell Function in Type 2 Diabetes and Their Modulation with Glucose Normalization (2022)
Journal Article
Moin, A. S. M., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2022). Diagnostic and Prognostic Protein Biomarkers of β-Cell Function in Type 2 Diabetes and Their Modulation with Glucose Normalization. Metabolites, 12(3), Article 196. https://doi.org/10.3390/metabo12030196

Development of type-2 diabetes(T2D) is preceded by β-cell dysfunction and loss. How-ever, accurate measurement of β-cell function remains elusive. Biomarkers have been reported to predict β-cell functional decline but require validation. Therefore, w... Read More about Diagnostic and Prognostic Protein Biomarkers of β-Cell Function in Type 2 Diabetes and Their Modulation with Glucose Normalization.

Predicting personalised and progressive adaptive dose escalation to gross tumour volume using knowledge-based planning models for inoperable advanced-stage non-small cell lung cancer patients treated with volumetric modulated arc therapy (2022)
Journal Article
Tambe, N., Pires, I. M., Moore, C., Wieczorek, A., Upadhyay, S., & Beavis, A. (2022). Predicting personalised and progressive adaptive dose escalation to gross tumour volume using knowledge-based planning models for inoperable advanced-stage non-small cell lung cancer patients treated with volumetric modulated arc therapy. Biomedical Physics and Engineering Express, 8(3), Article 035001. https://doi.org/10.1088/2057-1976/ac56eb

Objectives: Increased radiation doses could improve local control and overall survival of lung cancer patients, however, this could be challenging without exceeding organs at risk (OAR) dose constraints especially for patients with advanced-stage dis... Read More about Predicting personalised and progressive adaptive dose escalation to gross tumour volume using knowledge-based planning models for inoperable advanced-stage non-small cell lung cancer patients treated with volumetric modulated arc therapy.

Network Pharmacology and Molecular Docking Study of the Chinese Miao Medicine Sidaxue in the Treatment of Rheumatoid Arthritis (2022)
Journal Article
Wu, N., Yuan, T., Yin, Z., Yuan, X., Sun, J., Wu, Z., Zhang, Q., Redshaw, C., Yang, S., & Dai, X. (2022). Network Pharmacology and Molecular Docking Study of the Chinese Miao Medicine Sidaxue in the Treatment of Rheumatoid Arthritis. Drug Design, Development and Therapy, 16, 435-466. https://doi.org/10.2147/DDDT.S330947

Purpose: This study aimed to investigate the molecular mechanisms of Compound Sidaxue (SX), a prescription of Chinese Miao medicine, in treating rheumatoid arthritis (RA) using network pharmacology and in vivo experimental approaches. Methods: Networ... Read More about Network Pharmacology and Molecular Docking Study of the Chinese Miao Medicine Sidaxue in the Treatment of Rheumatoid Arthritis.

Perspectives of stakeholders of the free maternity services for mothers in western Kenya: lessons for universal health coverage (2022)
Journal Article
Ochieng, B. M., Kaseje, M., Kaseje, D. C. O., Oria, K., & Magadi, M. (2022). Perspectives of stakeholders of the free maternity services for mothers in western Kenya: lessons for universal health coverage. BMC health services research, 22(1), Article 226. https://doi.org/10.1186/s12913-022-07632-z

Background: The strategic aim of universal health coverage (UHC) is to ensure that everyone can use health services they need without risk of financial hardship. Linda Mama (Taking care of the mother) initiative focuses on the most vulnerable women,... Read More about Perspectives of stakeholders of the free maternity services for mothers in western Kenya: lessons for universal health coverage.

Effect of Moderate Aerobic Exercise on Complement Activation Pathways in Polycystic Ovary Syndrome Women (2022)
Journal Article
Ramanjaneya, M., Abdalhakam, I., Bettahi, I., Bensila, M., Jerobin, J., Aye, M. M., Alkasem, M., Sathyapalan, T., Atkin, S. L., & Abou-Samra, A. B. (2022). Effect of Moderate Aerobic Exercise on Complement Activation Pathways in Polycystic Ovary Syndrome Women. Frontiers in endocrinology, 12, Article 740703. https://doi.org/10.3389/fendo.2021.740703

Background: The complement system is pivotal in host defense mechanisms, protecting against pathogenic infection by regulating inflammation and cell immunity. Complement-related protein activation occurs through three distinct pathways: classical, al... Read More about Effect of Moderate Aerobic Exercise on Complement Activation Pathways in Polycystic Ovary Syndrome Women.

Impacts of Sodium/Glucose Cotransporter-2 Inhibitors on Circulating Uric Acid Concentrations: A Systematic Review and Meta-Analysis (2022)
Journal Article
Akbari, A., Rafiee, M., Sathyapalan, T., & Sahebkar, A. (2022). Impacts of Sodium/Glucose Cotransporter-2 Inhibitors on Circulating Uric Acid Concentrations: A Systematic Review and Meta-Analysis. Journal of Diabetes Research, 2022, Article 7520632. https://doi.org/10.1155/2022/7520632

Background: Several trials have assessed the antihyperglycemic effects of sodium/glucose cotransporter-2 inhibitors (SGLT2i) in patients with type 2 diabetes mellitus (T2DM). We conducted a quantitative analysis to assess the impact of SGLT2is on ser... Read More about Impacts of Sodium/Glucose Cotransporter-2 Inhibitors on Circulating Uric Acid Concentrations: A Systematic Review and Meta-Analysis.

Towards codesign in respiratory care: development of an implementation-ready intervention to improve guideline-adherent adult asthma care across primary and secondary care settings (The SENTINEL Project) (2022)
Journal Article
Crowther, L., Pearson, M., Cummings, H., & Crooks, M. G. (2022). Towards codesign in respiratory care: development of an implementation-ready intervention to improve guideline-adherent adult asthma care across primary and secondary care settings (The SENTINEL Project). BMJ Open Respiratory Research, 9(1), Article e001155. https://doi.org/10.1136/bmjresp-2021-001155

Short-acting beta agonist (SABA) overuse (≥3 canisters annually) is associated with worse asthma outcomes and accounts for the majority of greenhouse gas emissions from asthma inhalers in England. Reducing SABA overuse aligns with the National Health... Read More about Towards codesign in respiratory care: development of an implementation-ready intervention to improve guideline-adherent adult asthma care across primary and secondary care settings (The SENTINEL Project).

Cancer stem cells: An overview of the pathophysiological and prognostic roles in colorectal cancer (2022)
Journal Article
Pashirzad, M., Sathyapalan, T., Sheikh, A., Kesharwani, P., & Sahebkar, A. (2022). Cancer stem cells: An overview of the pathophysiological and prognostic roles in colorectal cancer. Process Biochemistry, 115, 19-29. https://doi.org/10.1016/j.procbio.2022.02.006

Colorectal cancer (CRC) is one of the most common types of cancer globally. A subpopulation of tumour cells, cancer stem cells (CSC), is speculated to be responsible for tumor initiation, development, maintenance, metastasis, and recurrence. Colorect... Read More about Cancer stem cells: An overview of the pathophysiological and prognostic roles in colorectal cancer.

Bullying, Cyberbullying, and Hate Speech (2022)
Journal Article
Cohen-Almagor, R. (2022). Bullying, Cyberbullying, and Hate Speech. International journal of technoethics, 13(1), 1-17. https://doi.org/10.4018/IJT.291552

The Internet's design and raison d'être are complete freedom, but complete freedom might lead to anarchy and to harmful and anti-social activities. In this paper I address the concepts of moral and social responsibility, applying them to the Internet... Read More about Bullying, Cyberbullying, and Hate Speech.

Pharmacy and Exercise as Complimentary Partners for Successful Cardiovascular Ageing (2022)
Journal Article
Howlett, L. A., Jones, S. A., & Lancaster, M. K. (2022). Pharmacy and Exercise as Complimentary Partners for Successful Cardiovascular Ageing. Current Vascular Pharmacology, 20(3), 284-302. https://doi.org/10.2174/1570161120666220107105840

Diseases of the cardiovascular system have been the biggest cause of mortality for the majority of the last century, currently contributing to almost a third of deaths every year globally. Ageing associates with changes to the structure and function... Read More about Pharmacy and Exercise as Complimentary Partners for Successful Cardiovascular Ageing.