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Imaging COX-2 expression in cancer using PET/SPECT radioligands: current status and future directions (2013)
Journal Article
Pacelli, A., Greenman, J., Cawthorne, C., & Smith, G. (2014). Imaging COX-2 expression in cancer using PET/SPECT radioligands: current status and future directions. Journal of Labelled Compounds and Radiopharmaceuticals, 57(4), 317-322. https://doi.org/10.1002/jlcr.3160

The role of cyclooxygenase (COX)-2 as a driving force in early tumourigenesis and the current interest in the combination of COX-2 inhibitors with standard therapy in clinical trials creates an urgent need to establish clinically relevant diagnostic... Read More about Imaging COX-2 expression in cancer using PET/SPECT radioligands: current status and future directions.

A Cdc42- and Rac-interactive binding (CRIB) domain mediates functions of coronin (2013)
Journal Article
Swaminathan, K., Müller-Taubenberger, A., Faix, J., Rivero, F., & Noegel, A. A. (2014). A Cdc42- and Rac-interactive binding (CRIB) domain mediates functions of coronin. Proceedings of the National Academy of Sciences of the United States of America, 111(1), E25-E33. https://doi.org/10.1073/pnas.1315368111

The Cdc42- and Rac-interactive binding motif (CRIB) of coronin binds to Rho GTPases with a preference for GDP-loaded Rac. Mutation of the Cdc42- and Rac-interactive binding motif abrogates Rac binding. This results in increased 1evels of activated Ra... Read More about A Cdc42- and Rac-interactive binding (CRIB) domain mediates functions of coronin.

Lanthanide(III) complexes of rhodamine-DO3A conjugates as agents for dual-modal imaging (2013)
Journal Article
Rivas, C., Stasiuk, G. J., Gallo, J., Minuzzi, F., Rutter, G. A., & Long, N. J. (2013). Lanthanide(III) complexes of rhodamine-DO3A conjugates as agents for dual-modal imaging. Inorganic chemistry, 52(24), 14284-14293. https://doi.org/10.1021/ic402233g

Two novel dual-modal MRI/optical probes based on a rhodamine-DO3A conjugate have been prepared. The bis aqua-Gd(III) complex Gd.L1 and mono aqua-Gd(III) complex Gd.L2 behave as dual-modal imaging probes (r1 = 8.5 and 3.8 mM-1s-1 for Gd.L1 and Gd.L2 r... Read More about Lanthanide(III) complexes of rhodamine-DO3A conjugates as agents for dual-modal imaging.

A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia (2013)
Journal Article
Speedy, H. E., Di Bernardo, M. C., Sava, G. P., Dyer, M. J. S., Holroyd, A., Wang, Y., …Houlston, R. S. (2014). A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia. Nature genetics, 46(1), 56-60. https://doi.org/10.1038/ng.2843

Genome-wide association studies (GWAS) of chronic lymphocytic leukemia (CLL) have shown that common genetic variation contributes to the heritable risk of CLL. To identify additional CLL susceptibility loci, we conducted a GWAS and performed a meta-a... Read More about A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.

Replication stress and chromatin context link ATM activation to a role in DNA replication (2013)
Journal Article
Olcina, M. M., Foskolou, I. P., Anbalagan, S., Senra, J. M., Pires, I. M., Jiang, Y., …Hammond, E. M. (2013). Replication stress and chromatin context link ATM activation to a role in DNA replication. Molecular cell, 52(5), 758-766. https://doi.org/10.1016/j.molcel.2013.10.019

ATM-mediated signaling in response to DNA damage is a barrier to tumorigenesis. Here we asked whether replication stress could also contribute to ATM signaling. We demonstrate that, in the absence of DNA damage, ATM responds to replication stress in... Read More about Replication stress and chromatin context link ATM activation to a role in DNA replication.

Filamin-A is required for the incorporation of tissue factor into cell-derived microvesicles (2013)
Journal Article
Collier, M. E. W., Ettelaie, C., & Maraveyas, A. (2014). Filamin-A is required for the incorporation of tissue factor into cell-derived microvesicles. Thrombosis and haemostasis, 111(4), 647-655. https://doi.org/10.1160/TH13-09-0769

We previously reported that the incorporation of tissue factor (TF) into cell-derived microvesicles (MVs) is regulated by the phosphorylation of the cytoplasmic domain of TF. Since the cytoskeletal protein filamin-A is known to bind to the cytoplasmi... Read More about Filamin-A is required for the incorporation of tissue factor into cell-derived microvesicles.

HDAC inhibitor confers radiosensitivity to prostate stem-like cells (2013)
Journal Article
Frame, F. M., Pellacani, D., Collins, A. T., Simms, M. S., Mann, V. M., Jones, G., …Maitland, N. J. (2013). HDAC inhibitor confers radiosensitivity to prostate stem-like cells. The British Journal of Cancer, 109(12), 3023-3033. https://doi.org/10.1038/bjc.2013.691

Background: Radiotherapy can be an effective treatment for prostate cancer, but radiorecurrent tumours do develop. Considering prostate cancer heterogeneity, we hypothesised that primitive stem-like cells may constitute the radiation-resistant fract... Read More about HDAC inhibitor confers radiosensitivity to prostate stem-like cells.

Regulation of cell survival by sphingosine-1-phosphate receptor S1P 1 via reciprocal ERK-dependent suppression of Bim and PI-3-kinase/protein kinase C-mediated upregulation of Mcl-1 (2013)
Journal Article
Rutherford, C., Childs, S., Ohotski, J., McGlynn, L., Riddick, M., MacFarlane, S., …Palmer, T. M. (2013). Regulation of cell survival by sphingosine-1-phosphate receptor S1P 1 via reciprocal ERK-dependent suppression of Bim and PI-3-kinase/protein kinase C-mediated upregulation of Mcl-1. Cell Death and Disease, 4(11), Article e927. https://doi.org/10.1038/cddis.2013.455

Although the ability of bioactive lipid sphingosine-1-phosphate (S1P) to positively regulate anti-apoptotic/pro-survival responses by binding to S1P1 is well known, the molecular mechanisms remain unclear. Here we demonstrate that expression of S1P1... Read More about Regulation of cell survival by sphingosine-1-phosphate receptor S1P 1 via reciprocal ERK-dependent suppression of Bim and PI-3-kinase/protein kinase C-mediated upregulation of Mcl-1.

The G-protein-coupled receptor CLR is upregulated in an autocrine loop with adrenomedullin in clear cell renal cell carcinoma and associated with poor prognosis (2013)
Journal Article
Nikitenko, L. L., Leek, R., Henderson, S., Pillay, N., Turley, H., Generali, D., …Fox, S. B. (2013). The G-protein-coupled receptor CLR is upregulated in an autocrine loop with adrenomedullin in clear cell renal cell carcinoma and associated with poor prognosis. Clinical cancer research : an official journal of the American Association for Cancer Research, 19(20), 5740-5748. https://doi.org/10.1158/1078-0432.CCR-13-1712

Purpose: The G-protein-coupled receptor (GPCR) calcitonin receptor-like receptor (CLR) and its ligand peptide adrenomedullin (encoded by ADM gene) are implicated in tumor angiogenesis in mouse models but poorly defined in human cancers. We therefore... Read More about The G-protein-coupled receptor CLR is upregulated in an autocrine loop with adrenomedullin in clear cell renal cell carcinoma and associated with poor prognosis.

PASD1: A Promising Target for the Immunotherapy of Haematological Malignancies (2013)
Journal Article
Khan, G., Denniss, F., Mills, K. I., Guinn, B., & Pulford, K. (2013). PASD1: A Promising Target for the Immunotherapy of Haematological Malignancies. Genetic Syndromes and Gene Therapy, 04(09), Article 186. https://doi.org/10.4172/2157-7412.1000186

In general, there is a lack of good immunotherapy targets within the spectrum of haematological malignancies. However haematopoietic stem cell transplants and continuing antigen discovery have allowed further insight into how further improvements in... Read More about PASD1: A Promising Target for the Immunotherapy of Haematological Malignancies.

Analysis of radiation-induced cell death in head and neck squamous cell carcinoma and rat liver maintained in microfluidic devices (2013)
Journal Article
Green, V. L., Greenman, J., Carr, S. D., & Stafford, N. D. (2014). Analysis of radiation-induced cell death in head and neck squamous cell carcinoma and rat liver maintained in microfluidic devices. Otolaryngology and head and neck surgery, 150(1), 73-80. https://doi.org/10.1177/0194599813507427

Objective The aim of this study was to investigate how head and neck squamous cell carcinoma (HNSCC) tissue biopsies maintained in a pseudo in vivo environment within a bespoke microfluidic device respond to radiation treatment. Study Design Feasibi... Read More about Analysis of radiation-induced cell death in head and neck squamous cell carcinoma and rat liver maintained in microfluidic devices.

Microparticle-associated tissue factor is recycled by endothelial cells resulting in enhanced surface tissue factor activity (2013)
Journal Article
Collier, M. E. W., Mah, P., Xiao, Y., Maraveyas, A., & Ettelaie, C. (2013). Microparticle-associated tissue factor is recycled by endothelial cells resulting in enhanced surface tissue factor activity. Thrombosis and haemostasis, 110(5), 966-976. https://doi.org/10.1160/TH13-01-0055

In this study the uptake of tissue factor (TF)-positive microparticles by endothelial cells and the recycling of the TF component were examined. Human dermal blood endothelial cells (HDBEC) were incubated with microparticles derived from cancer cell... Read More about Microparticle-associated tissue factor is recycled by endothelial cells resulting in enhanced surface tissue factor activity.

Identification and characterisation of mutations associated with von Willebrand disease in a Turkish patient cohort (2013)
Journal Article
Hampshire, D. J., Abuzenadah, A. M., Cartwright, A., Al-Shammari, N. S., Coyle, R. E., Eckert, M., …Goodeve, A. C. (2013). Identification and characterisation of mutations associated with von Willebrand disease in a Turkish patient cohort. Thrombosis and haemostasis, 110(2), 264-274. https://doi.org/10.1160/TH13-02-0135

Several cohort studies have investigated the molecular basis of von Willebrand disease (VWD); however, these have mostly focused on European and North American populations. This study aimed to investigate mutation spectrum in 26 index cases (IC) from... Read More about Identification and characterisation of mutations associated with von Willebrand disease in a Turkish patient cohort.

Proteomic analysis of B-cell receptor signaling in chronic lymphocytic leukaemia reveals a possible role for kininogen (2013)
Journal Article
Kashuba, E., Eagle, G. L., Bailey, J., Evans, P., Welham, K. J., Allsup, D., & Cawkwell, L. (2013). Proteomic analysis of B-cell receptor signaling in chronic lymphocytic leukaemia reveals a possible role for kininogen. Journal of Proteomics, 91, 478-485. https://doi.org/10.1016/j.jprot.2013.08.002

CLL is an incurable disease with variable prognosis. The hyper reactivity of the B-cell receptor (BCR) to unknown antigen ligation plays a pivotal role in CLL-cell survival. We aimed to investigate the BCR signalling pathway using proteomics to ident... Read More about Proteomic analysis of B-cell receptor signaling in chronic lymphocytic leukaemia reveals a possible role for kininogen.

Protein arginine methyl transferases-3 and -5 increase cell surface expression of cardiac sodium channel (2013)
Journal Article
Beltran-Alvarez, P., Espejo, A., Schmauder, R., Beltran, C., Mrowka, R., Linke, T., …Brugada, R. (2013). Protein arginine methyl transferases-3 and -5 increase cell surface expression of cardiac sodium channel. FEBS Letters, 587(19), 3159-3165. https://doi.org/10.1016/j.febslet.2013.07.043

The α-subunit of the cardiac voltage-gated sodium channel (Na V1.5) plays a central role in cardiomyocyte excitability. We have recently reported that NaV1.5 is post-translationally modified by arginine methylation. Here, we aimed to identify the enz... Read More about Protein arginine methyl transferases-3 and -5 increase cell surface expression of cardiac sodium channel.

An analogue peptide from the cancer/testis antigen PASD1 induces CD8+ T cell responses against naturally processed peptide (2013)
Journal Article
Hardwick, N., Buchan, S., Ingram, W., Khan, G., Vittes, G., Rice, J., …Guinn, B. A. (2013). An analogue peptide from the cancer/testis antigen PASD1 induces CD8+ T cell responses against naturally processed peptide. Cancer Immunology Research, 13(3), 16-26. https://doi.org/10.1158/1424-9634.DCL-16.13.3

We have previously identified the novel Cancer/Testis antigen PASD1 by immunoscreening a testis library with pooled acute myeloid leukemia (AML) patient sera. To develop a cytotoxic T lymphocyte (CTL)-inducing vaccine, we have now investigated the ca... Read More about An analogue peptide from the cancer/testis antigen PASD1 induces CD8+ T cell responses against naturally processed peptide.

Increased frequency and suppressive activity of CD127low/- regulatory T cells in the peripheral circulation of patients with head and neck squamous cell carcinoma are associated with advanced stage and nodal involvement (2013)
Journal Article
Drennan, S., Stafford, N. D., Greenman, J., & Green, V. (2013). Increased frequency and suppressive activity of CD127low/- regulatory T cells in the peripheral circulation of patients with head and neck squamous cell carcinoma are associated with advanced stage and nodal involvement. Immunology, 140(3), 335-343. https://doi.org/10.1111/imm.12144

The presence of regulatory T (Treg) cells is thought to be an important mechanism by which head and neck squamous cell carcinoma (HNSCC) successfully evades the immune system. Using multicolour flow cytometry, the frequency and functional capacity of... Read More about Increased frequency and suppressive activity of CD127low/- regulatory T cells in the peripheral circulation of patients with head and neck squamous cell carcinoma are associated with advanced stage and nodal involvement.

Muscle ERRγ mitigates Duchenne muscular dystrophy via metabolic and angiogenic reprogramming (2013)
Journal Article
Matsakas, A., Yadav, V., Lorca, S., & Narkar, V. (2013). Muscle ERRγ mitigates Duchenne muscular dystrophy via metabolic and angiogenic reprogramming. FASEB Journal, 27(10), 4004-4016. https://doi.org/10.1096/fj.13-228296

Treatment of Duchenne muscular dystrophy (DMD) by replacing mutant dystrophin or restoring dystrophin-associated glycoprotein complex (DAG) has been clinically challenging. Instead, identifying and targeting muscle pathways deregulated in DMD will pr... Read More about Muscle ERRγ mitigates Duchenne muscular dystrophy via metabolic and angiogenic reprogramming.

An attenuating role of a WASP-related protein, WASP-B, in the regulation of F-actin polymerization and pseudopod formation via the regulation of RacC during Dictyostelium chemotaxis (2013)
Journal Article
Chung, C. Y., Feoktistov, A., Hollingsworth, R. J., Rivero, F., & Mandel, N. S. (2013). An attenuating role of a WASP-related protein, WASP-B, in the regulation of F-actin polymerization and pseudopod formation via the regulation of RacC during Dictyostelium chemotaxis. Biochemical and biophysical research communications, 436(4), 719-724. https://doi.org/10.1016/j.bbrc.2013.06.022

The WASP family of proteins has emerged as important regulators that connect multiple signaling pathways to regulate the actin cytoskeleton. Dictyostelium cells express WASP, as well as a WASP related protein, WASP-B, endoded by wasB gene. WASP-B con... Read More about An attenuating role of a WASP-related protein, WASP-B, in the regulation of F-actin polymerization and pseudopod formation via the regulation of RacC during Dictyostelium chemotaxis.