All Outputs (30)

Linking Ras to myosin function: RasGEF Q, a Dictyostelium exchange factor for RasB, affects myosin II functions (2008)
Journal Article
Mondal, S., Bakthavatsalam, D., Steimle, P., Gassen, B., Rivero, F., & Noegel, A. A. (2008). Linking Ras to myosin function: RasGEF Q, a Dictyostelium exchange factor for RasB, affects myosin II functions. Journal of Cell Biology, 181(5), 747-760. https://doi.org/10.1083/jcb.200710111

Ras guanine nucleotide exchange factor (GEF) Q, a nucleotide exchange factor from Dictyostelium discoideum, is a 143-kD protein containing RasGEF domains and a DEP domain. We show that RasGEF Q can bind to F-actin, has the potential to form complexes... Read More about Linking Ras to myosin function: RasGEF Q, a Dictyostelium exchange factor for RasB, affects myosin II functions.

Synthetic CD4+ T cell-targeted antigen-presenting cells elicit protective antitumor responses (2008)
Journal Article
Caserta, S., Alessi, P., Guarnerio, J., Basso, V., & Mondino, A. (2008). Synthetic CD4+ T cell-targeted antigen-presenting cells elicit protective antitumor responses. Cancer Research, 68(8), 3010-3018. https://doi.org/10.1158/0008-5472.can-07-5796

CD4 + helper T cells are critical for protective immune responses and yet suboptimally primed in response to tumors. Cell-based vaccination strategies are under evaluation in clinical trials but limited by the need to derive antigenpresenting cells... Read More about Synthetic CD4+ T cell-targeted antigen-presenting cells elicit protective antitumor responses.

Microparticle-associated vascular adhesion molecule-1 and tissue factor follow a circadian rhythm in healthy human subjects (2008)
Journal Article
Madden, L. A., Vince, R. V., Sandström, M. E., Taylor, L., McNaughton, L., & Laden, G. (2008). Microparticle-associated vascular adhesion molecule-1 and tissue factor follow a circadian rhythm in healthy human subjects. Thrombosis and haemostasis, 99(5), 909 - 915. https://doi.org/10.1160/th08-01-0030

An increased risk of death or severe injury due to late-morning thrombotic events is well established. Tissue factor (TF) is the initiator of the coagulation cascade, and endothelial stresses, coupled with production of pro-coagulant microparticles (... Read More about Microparticle-associated vascular adhesion molecule-1 and tissue factor follow a circadian rhythm in healthy human subjects.

Distinguishing Properties of Cells From the Myocardial Sleeves of the Pulmonary Veins: A Comparison of Normal and Abnormal Pacemakers (2008)
Journal Article
Jones, S. A., Yamamoto, M., Tellez, J. O., Billeter, R., Boyett, M. R., Honjo, H., & Lancaster, M. K. (2008). Distinguishing Properties of Cells From the Myocardial Sleeves of the Pulmonary Veins: A Comparison of Normal and Abnormal Pacemakers. Circulation. Arrhythmia and electrophysiology, 1(1), 39-48. https://doi.org/10.1161/CIRCEP.107.748467

BACKGROUND: A common source of arrhythmogenic spontaneous activity instigating atrial fibrillation is the myocardial tissue, or sleeves, at the base of the pulmonary veins. This study compared the properties of cells from the myocardial sleeves of th... Read More about Distinguishing Properties of Cells From the Myocardial Sleeves of the Pulmonary Veins: A Comparison of Normal and Abnormal Pacemakers.

Dictyostelium Sun-1 connects the centrosome to chromatin and ensures genome stability (2008)
Journal Article
Rivero, F., Xiong, H., Rivero-Crespo, F., Euteneuer, U., Mondal, S., Mana-Capelli, S., Larochelle, D., Vogel, A., Gassen, B., & Noegel, A. A. (2008). Dictyostelium Sun-1 connects the centrosome to chromatin and ensures genome stability. Traffic, 9(5), 708-724. https://doi.org/10.1111/j.1600-0854.2008.00721.x

The centrosome-nucleus attachment is a prerequisite for faithful chromosome segregation during mitosis. We addressed the function of the nuclear envelope (NE) protein Sun-1 in centrosome-nucleus connection and the maintenance of genome stability in D... Read More about Dictyostelium Sun-1 connects the centrosome to chromatin and ensures genome stability.

Investigation of the mechanisms of tissue factor-mediated evasion of tumour cells from cellular cytotoxicity (2008)
Journal Article
Li, C., Collier, M. E. W., Frentzou, G. A., Greenman, J., & Ettelaie, C. (2008). Investigation of the mechanisms of tissue factor-mediated evasion of tumour cells from cellular cytotoxicity. Cancer Immunology, Immunotherapy, 57(9), 1347-1355. https://doi.org/10.1007/s00262-008-0469-6

Aims We previously reported that overexpression of tissue factor (TF) protected HT29 tumour cells from cellular cytotoxicity through a mechanism requiring the presence of the cytoplasmic domain of TF. In this investigation the mechanism of TF-mediate... Read More about Investigation of the mechanisms of tissue factor-mediated evasion of tumour cells from cellular cytotoxicity.

Fluvastatin reduces oxidative damage in human vascular endothelial cells by upregulating Bcl-2 (2008)
Journal Article
Xu, S. Z., Zhong, W., Watson, N. M., Dickerson, E., Wake, J. D., Lindow, S. W., Newton, C. J., & Atkin, S. L. (2008). Fluvastatin reduces oxidative damage in human vascular endothelial cells by upregulating Bcl-2. Journal of thrombosis and haemostasis : JTH, 6(4), 692-700. https://doi.org/10.1111/j.1538-7836.2008.02913.x

Background: 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) have been widely used in clinical practise and their efficacy in reducing cardiovascular risk has been well described. Objectives: To investigate the effect of low doses... Read More about Fluvastatin reduces oxidative damage in human vascular endothelial cells by upregulating Bcl-2.

Regulatory T cells: what role do they play in antitumor immunity in patients with head and neck cancer? (2008)
Journal Article
Alhamarneh, O., Amarnath, S. M. P., Stafford, N. D., & Greenman, J. (2008). Regulatory T cells: what role do they play in antitumor immunity in patients with head and neck cancer?. Head & neck, 30(2), 251-261. https://doi.org/10.1002/hed.20739

Advances in the treatment modalities for head and neck squamous cell carcinoma (HNSCC) over the last 20 years involving surgery, radiotherapy, chemotherapy, and immunotherapy are not fully reflected in increases in the 5-year survival rates, mainly d... Read More about Regulatory T cells: what role do they play in antitumor immunity in patients with head and neck cancer?.

TRPC channel activation by extracellular thioredoxin (2008)
Journal Article
Xu, S.-Z., Sukumar, P., Zeng, F., Li, J., Jairaman, A., English, A., Naylor, J., Ciurtin, C., Majeed, Y., Milligan, C. J., Bahnasi, Y. M., Al-Shawaf, E., Porter, K. E., Jiang, L.-H., Emery, P., Sivaprasadarao, A., & Beech, D. J. (2008). TRPC channel activation by extracellular thioredoxin. Nature, 451(7174), 69-72. https://doi.org/10.1038/nature06414

Mammalian homologues of Drosophila melanogaster transient receptor potential (TRP) are a large family of multimeric cation channels that act, or putatively act, as sensors of one or more chemical factor. Major research objectives are the identificati... Read More about TRPC channel activation by extracellular thioredoxin.

Development of a microfluidic device for the maintenance and interrogation of viable tissue biopsies (2008)
Journal Article
Dyer, C. E., Greenman, J., Haswell, S. J., & Hattersley, S. M. (2008). Development of a microfluidic device for the maintenance and interrogation of viable tissue biopsies. Lab on a chip, 8(11), 1842-1846. https://doi.org/10.1039/b809345h

A microfluidic based experimental methodology has been developed that offers a biomimetic microenvironment in which pseudo in vivo tissue studies can be carried out under in vitro conditions. Using this innovative technique, which utilizes the inhere... Read More about Development of a microfluidic device for the maintenance and interrogation of viable tissue biopsies.