All Outputs (917)

Integrated microfluidic lab-on-a-chip systems for F-18 radiotracer synthesis, purification and quality control (2015)
Journal Article
Archibald, S., Pamme, N., Brown, N., & Tarn, M. (2015). Integrated microfluidic lab-on-a-chip systems for F-18 radiotracer synthesis, purification and quality control. Journal of nuclear medicine, 56(Supplement 3), Article 167

Objectives Dose-on-demand radiotracer production, whereby a single dose is generated using a compact synthesis unit with radioisotope from a mini-cyclotron or external supply is an interesting prospect for widening the availabilty of radiotracers. We... Read More about Integrated microfluidic lab-on-a-chip systems for F-18 radiotracer synthesis, purification and quality control.

Accumulation of tissue factor in endothelial cells induces cell apoptosis, mediated through p38 and p53 activation (2015)
Journal Article
ElKeeb, A. M., Collier, M. E. W., Maraveyas, A., & Ettelaie, C. (2015). Accumulation of tissue factor in endothelial cells induces cell apoptosis, mediated through p38 and p53 activation. Thrombosis and haemostasis, 114(2), 364-378. https://doi.org/10.1160/th14-09-0795

We previously reported that high levels of tissue factor (TF) can induce cellular apoptosis in endothelial. In this study, TF-mediated mechanisms of induction of apoptosis were explored. Endothelial cells were transfected to express wild-type TF. Add... Read More about Accumulation of tissue factor in endothelial cells induces cell apoptosis, mediated through p38 and p53 activation.

Human platelet IgG Fc receptor FcγRIIA in immunity and thrombosis (2015)
Journal Article
Arman, M., & Krauel, K. (2015). Human platelet IgG Fc receptor FcγRIIA in immunity and thrombosis. Journal of thrombosis and haemostasis : JTH, 13(6), 893-908. https://doi.org/10.1111/jth.12905

© 2015 International Society on Thrombosis and Haemostasis. Beyond their prominent role in hemostasis and thrombosis, platelets are increasingly recognized as having immunologic functions. Supporting this, human platelets express FcγRIIA (CD32a), a l... Read More about Human platelet IgG Fc receptor FcγRIIA in immunity and thrombosis.

Synthesis, structural studies, kinetic stability, and oxidation catalysis of the late first row transition metal complexes of 4,10-dimethyl-1,4,7,10-tetraazabicyclo[6.5.2]pentadecane (2015)
Journal Article
Matz, D. L., Jones, D. G., Roewe, K. D., Gorbet, M.-J., Zhang, Z., Chen, Z., Prior, T. J., Archibald, S. J., Yin, G., & Hubin, T. J. (2015). Synthesis, structural studies, kinetic stability, and oxidation catalysis of the late first row transition metal complexes of 4,10-dimethyl-1,4,7,10-tetraazabicyclo[6.5.2]pentadecane. Dalton Transactions : an international journal of inorganic chemistry, 44(27), 12210-12224. https://doi.org/10.1039/c5dt00742a

© The Royal Society of Chemistry 2015. Synthetic details for 4,11-dimethyl-1,4,8,11-tetraazabicyclo[6.5.2]pentadecane, the dimethyl ethylene cross-bridged homocyclen ligand are presented for the first time. Its novel Mn 2+ , Fe 2+ , Mn 3+ , and Fe 3+... Read More about Synthesis, structural studies, kinetic stability, and oxidation catalysis of the late first row transition metal complexes of 4,10-dimethyl-1,4,7,10-tetraazabicyclo[6.5.2]pentadecane.

Low-temperature plasma treatment induces DNA damage leading to necrotic cell death in primary prostate epithelial cells (2015)
Journal Article
Hirst, A. M., Simms, M. S., Mann, V. M., Maitland, N. J., O'Connell, D., & Frame, F. M. (2015). Low-temperature plasma treatment induces DNA damage leading to necrotic cell death in primary prostate epithelial cells. The British Journal of Cancer, 112(9), 1536-1545. https://doi.org/10.1038/bjc.2015.113

Background: In recent years, the rapidly advancing field of low-temperature atmospheric pressure plasmas has shown considerable promise for future translational biomedical applications, including cancer therapy, through the generation of reactive ox... Read More about Low-temperature plasma treatment induces DNA damage leading to necrotic cell death in primary prostate epithelial cells.

The future of EPAC-targeted therapies: Agonism versus antagonism (2015)
Journal Article
Parnell, E., Palmer, T. M., & Yarwood, S. J. (2015). The future of EPAC-targeted therapies: Agonism versus antagonism. Trends in Pharmacological Sciences, 36(4), 203-214. https://doi.org/10.1016/j.tips.2015.02.003

Pharmaceutical manipulation of cAMP levels exerts beneficial effects through the regulation of the exchange protein activated by cAMP (EPAC) and protein kinase A (PKA) signalling routes. Recent attention has turned to the specific regulation of EPAC... Read More about The future of EPAC-targeted therapies: Agonism versus antagonism.

αIIbβ3 variants defined by next-generation sequencing: Predicting variants likely to cause Glanzmann thrombasthenia (2015)
Journal Article
Buitrago, L., Rendon, A., Liang, Y., Simeoni, I., Negri, A., ThromboGenomics Consortium, Filizola, M., Ouwehand, W. H., & Coller, B. S. (2015). αIIbβ3 variants defined by next-generation sequencing: Predicting variants likely to cause Glanzmann thrombasthenia. Proceedings of the National Academy of Sciences of the United States of America, 112(15), E1898-E1907. https://doi.org/10.1073/pnas.1422238112

Next-generation sequencing is transforming our understanding of human genetic variation but assessing the functional impact of novel variants presents challenges. We analyzed missense variants in the integrin αIIbβ3 receptor subunit genes ITGA2B and... Read More about αIIbβ3 variants defined by next-generation sequencing: Predicting variants likely to cause Glanzmann thrombasthenia.

Erratum: RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2 (Nature Cell Biology (2014) 16 (962-971)) (2015)
Journal Article
Pefani, D. E., Latusek, R., Pires, I., Grawenda, A. M., Yee, K. S., Hamilton, G., Van Der Weyden, L., Esashi, F., Hammond, E. M., & O'neill, E. (2015). Erratum: RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2 (Nature Cell Biology (2014) 16 (962-971)). Nature Cell Biology, 17(4), 531. https://doi.org/10.1038/ncb3152

Symmorphosis through dietary regulation: A combinatorial role for proteolysis, autophagy and protein synthesis in normalising muscle metabolism and function of hypertrophic mice after acute starvation (2015)
Journal Article
Collins-Hooper, H., Sartori, R., Giallourou, N., Matsakas, A., Mitchell, R., Mararenkova, H., Flasskamp, H., Macharia, R., Ray, S., Swann, J. R., Sandri, M., & Patel, K. (2015). Symmorphosis through dietary regulation: A combinatorial role for proteolysis, autophagy and protein synthesis in normalising muscle metabolism and function of hypertrophic mice after acute starvation. PLoS ONE, 10(3), e0120524. https://doi.org/10.1371/journal.pone.0120524

Animals are imbued with adaptive mechanisms spanning from the tissue/organ to the cellular scale which insure that processes of homeostasis are preserved in the landscape of size change. However we and others have postulated that the degree of adapta... Read More about Symmorphosis through dietary regulation: A combinatorial role for proteolysis, autophagy and protein synthesis in normalising muscle metabolism and function of hypertrophic mice after acute starvation.

Collateral donor artery physiology and the influence of a chronic total occlusion on fractional flow reserve (2015)
Journal Article
Ladwiniec, A., Cunnington, M. S., Rossington, J., Mather, A. N., Alahmar, A., Oliver, R. M., Nijjer, S. S., Davies, J. E., Thackray, S., Alamgir, F., & Hoye, A. (2015). Collateral donor artery physiology and the influence of a chronic total occlusion on fractional flow reserve. Circulation. Cardiovascular interventions, 8(4), Article UNSP e002219. https://doi.org/10.1161/CIRCINTERVENTIONS.114.002219

Background— The presence of a concomitant chronic total coronary occlusion (CTO) and a large collateral contribution might alter the fractional flow reserve (FFR) of an interrogated vessel, rendering the FFR unreliable at predicting ischemia should t... Read More about Collateral donor artery physiology and the influence of a chronic total occlusion on fractional flow reserve.

Clinical and molecular characterization of a cardiac ryanodine receptor founder mutation causing catecholaminergic polymorphic ventricular tachycardia (2015)
Journal Article
Wangüemert, F., Bosch Calero, C., Pérez, C., Campuzano, O., Beltran-Alvarez, P., Scornik, F. S., Iglesias, A., Berne, P., Allegue, C., Ruiz Hernandez, P. M., Brugada, J., Pérez, G. J., & Brugada, R. (2015). Clinical and molecular characterization of a cardiac ryanodine receptor founder mutation causing catecholaminergic polymorphic ventricular tachycardia. Heart rhythm : the official journal of the Heart Rhythm Society, 12(7), 1636-1643. https://doi.org/10.1016/j.hrthm.2015.03.033

Background Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a difficult-to-diagnose cause of sudden cardiac death (SCD). We identified a family of 1400 individuals with multiple cases of CPVT, including 36 SCDs during youth. Objectives... Read More about Clinical and molecular characterization of a cardiac ryanodine receptor founder mutation causing catecholaminergic polymorphic ventricular tachycardia.

Prostate cancer cells stimulated by calcium-mediated activation of protein kinase C undergo a refractory period before re-releasing calcium-bearing microvesicles (2015)
Journal Article
Stratton, D., Moore, C., Zheng, L., Lange, S., & Inal, J. (2015). Prostate cancer cells stimulated by calcium-mediated activation of protein kinase C undergo a refractory period before re-releasing calcium-bearing microvesicles. Biochemical and biophysical research communications, 460(3), 511-517. https://doi.org/10.1016/j.bbrc.2015.03.061

© 2015 Elsevier Inc.All rights reserved. MVs are released in response to several stress agents, in an attempt to prevent continued cellular damage. After an initial stimulus of prostate cancer cells with sublytic C5b-9 and activation of MV release th... Read More about Prostate cancer cells stimulated by calcium-mediated activation of protein kinase C undergo a refractory period before re-releasing calcium-bearing microvesicles.

IL-24 Inhibits lung cancer cell migration and invasion by disrupting the SDF-1/CXCR4 signaling axis (2015)
Journal Article
Panneerselvam, J., Jin, J., Shanker, M., Lauderdale, J., Bates, J., Wang, Q., Zhao, Y. D., Archibald, S. J., Hubin, T. J., & Ramesh, R. (2015). IL-24 Inhibits lung cancer cell migration and invasion by disrupting the SDF-1/CXCR4 signaling axis. PLoS ONE, 10(3), Article e0122439. https://doi.org/10.1371/journal.pone.0122439

© 2015 Panneerselvam et al. Background The stromal cell derived factor (SDF)-1/chemokine receptor (CXCR)-4 signaling pathway plays a key role in lung cancer metastasis and is molecular target for therapy. In the present study we investigated whether... Read More about IL-24 Inhibits lung cancer cell migration and invasion by disrupting the SDF-1/CXCR4 signaling axis.

Dual-modal magnetic resonance/fluorescent zinc probes for pancreatic β-cell mass imaging (2015)
Journal Article
Stasiuk, G. J., Minuzzi, F., Sae-Heng, M., Rivas, C., Juretschke, H.-P., Piemonti, L., Allegrini, P. R., Laurent, D., Duckworth, A. R., Beeby, A., Rutter, G. A., & Long, N. J. (2015). Dual-modal magnetic resonance/fluorescent zinc probes for pancreatic β-cell mass imaging. Chemistry: a European journal, 21(13), 5023-5033. https://doi.org/10.1002/chem.201406008

Despite the contribution of changes in pancreatic β-cell mass to the development of all forms of diabetes mellitus, few robust approaches currently exist to monitor these changes prospectively in vivo. Although magnetic-resonance imaging (MRI) provid... Read More about Dual-modal magnetic resonance/fluorescent zinc probes for pancreatic β-cell mass imaging.

Progressive age-associated activation of JNK associates with conduction disruption in the aged atrium (2015)
Journal Article
Jones, S. A., & Lancaster, M. K. (2015). Progressive age-associated activation of JNK associates with conduction disruption in the aged atrium. Mechanisms of ageing and development, 146-148, 72-80. https://doi.org/10.1016/j.mad.2015.05.001

Connexin43 (Cx43) is critical for maintaining electrical conduction across atrial muscle. During progressive ageing atrial conduction slows associating with increasing susceptibility to arrhythmias. Changes in Cx43 protein expression, or its phosphor... Read More about Progressive age-associated activation of JNK associates with conduction disruption in the aged atrium.

A novel zinc finger gene, ZNF465, is inappropriately expressed in acute myeloid leukaemia cells (2015)
Journal Article
Collin, J. F., Wells, J. W., Czepulkowski, B., Lyne, L., Duriez, P. J., Banham, A. H., Mufti, G. J., & Guinn, B. A. (2015). A novel zinc finger gene, ZNF465, is inappropriately expressed in acute myeloid leukaemia cells. Genes, Chromosomes and Cancer, 54(5), 288-302. https://doi.org/10.1002/gcc.22242

To increase our knowledge of leukaemia‐associated antigens, especially in acute myeloid leukaemia (AML) M4, we prepared a phage display cDNA library using mRNA from the bone marrow cells of a patient with AML M4 at diagnosis. We immunoscreened 106 pf... Read More about A novel zinc finger gene, ZNF465, is inappropriately expressed in acute myeloid leukaemia cells.

Oxidized LDL activates blood platelets through CD36/NOX2–mediated inhibition of the cGMP/protein kinase G signaling cascade (2015)
Journal Article
Magwenzi, S., Woodward, C., Wraith, K. S., Aburima, A., Raslan, Z., Jones, H., McNeil, C., Wheatcroft, S., Yuldasheva, N., Febbriao, M., Kearney, M., & Naseem, K. M. (2015). Oxidized LDL activates blood platelets through CD36/NOX2–mediated inhibition of the cGMP/protein kinase G signaling cascade. Blood, 125(17), 2693-2703. https://doi.org/10.1182/blood-2014-05-574491

Oxidized low-density lipoprotein (oxLDL) promotes unregulated platelet activation in dyslipidemic disorders. Although oxLDL stimulates activatory signaling, it is unclear how these events drive accelerated thrombosis. Here, we describe a mechanism fo... Read More about Oxidized LDL activates blood platelets through CD36/NOX2–mediated inhibition of the cGMP/protein kinase G signaling cascade.

Differentiating between monozygotic twins through DNA methylation-specific high-resolution melt curve analysis (2015)
Journal Article
Stewart, L., Evans, N., Bexon, K. J., Van Der Meer, D. J., & Williams, G. A. (2015). Differentiating between monozygotic twins through DNA methylation-specific high-resolution melt curve analysis. Analytical Biochemistry, 476, 36-39. https://doi.org/10.1016/j.ab.2015.02.001

Although short tandem repeat profiling is extremely powerful in identifying individuals from crime scene stains, it is unable to differentiate between monozygotic (MZ) twins. Efforts to address this include mutation analysis through whole genome sequ... Read More about Differentiating between monozygotic twins through DNA methylation-specific high-resolution melt curve analysis.

Does radiation-induced c-MYC amplification initiate breast oncogenesis? (2015)
Journal Article
Wade, M. A., May, F. E., Onel, K., & Allan, J. M. (2016). Does radiation-induced c-MYC amplification initiate breast oncogenesis?. Molecular and Cellular Oncology, 3(1), Article e1010950. https://doi.org/10.1080/23723556.2015.1010950

© 2016 Taylor and Francis Group, LLC. The MYC (v-myc avian myelocytomatosis viral oncogene homolog; c-MYC) locus on chromosome 8q is susceptible to high-level amplification following exposure of human breast cells to ionizing radiation, and c-MYC amp... Read More about Does radiation-induced c-MYC amplification initiate breast oncogenesis?.

Extracellular vesicles, tissue factor, cancer and thrombosis – discussion themes of the ISEV 2014 Educational Day (2015)
Journal Article
Gardiner, C., Harrison, P., Belting, M., Böing, A., Campello, E., Carter, B. S., Collier, M. E., Coumans, F., Ettelaie, C., Van Es, N., Hochberg, F. H., Mackman, N., Rennert, R. C., Thaler, J., Rak, J., & Nieuwland, R. (2015). Extracellular vesicles, tissue factor, cancer and thrombosis – discussion themes of the ISEV 2014 Educational Day. Journal of Extracellular Vesicles, 4(1), 1-14. https://doi.org/10.3402/jev.v4.26901

Although the association between cancer and venous thromboembolism (VTE) has long been known, the mechanisms are poorly understood. Circulating tissue factor-bearing extracellular vesicles have been proposed as a possible explanation for the increase... Read More about Extracellular vesicles, tissue factor, cancer and thrombosis – discussion themes of the ISEV 2014 Educational Day.