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Identification of a novel, actin-rich structure, the actin nodule, in the early stages of platelet spreading (2008)
Journal Article
Calaminus, S. D. J., Thomas, S., McCarty, O. J. T., Machesky, L. M., & Watson, S. P. (2008). Identification of a novel, actin-rich structure, the actin nodule, in the early stages of platelet spreading. Journal of thrombosis and haemostasis : JTH, 6(11), 1944-1952. https://doi.org/10.1111/j.1538-7836.2008.03141.x

During platelet spreading, the actin cytoskeleton undergoes marked changes, forming filopodia, lamellipodia and stress fibres. In the present study, we report the identification of a novel actin-rich structure, termed an actin nodule, which appears p... Read More about Identification of a novel, actin-rich structure, the actin nodule, in the early stages of platelet spreading.

DNA damage and metabolic activity in the preimplantation embryo (2008)
Journal Article
Sturmey, R. G., Hawkhead, J. A., Barker, E. A., & Leese, H. J. (2009). DNA damage and metabolic activity in the preimplantation embryo. Human Reproduction, 24(1), 81-91. https://doi.org/10.1093/humrep/den346

BACKGROUND: Embryos with greater viability have a lower or 'quieter' amino acid metabolism than those which arrest. We have hypothesized this is due to non-viable embryos possessing greater cellular/molecular damage and consuming more nutrients, such... Read More about DNA damage and metabolic activity in the preimplantation embryo.

Globular adiponectin increases cGMP formation in blood platelets independently of nitric oxide (2008)
Journal Article
Riba, R., Patel, B., Aburima, A., & Naseem, K. M. (2008). Globular adiponectin increases cGMP formation in blood platelets independently of nitric oxide. Journal of thrombosis and haemostasis : JTH, 6(12), 2121-2131. https://doi.org/10.1111/j.1538-7836.2008.03179.x

Background: Platelet-derived nitric oxide (NO) has been shown to play conflicting roles in platelet function, although it is accepted that NO mediates its actions through soluble guanylyl cyclase (sGC). This confusion concerning the roles of platelet... Read More about Globular adiponectin increases cGMP formation in blood platelets independently of nitric oxide.

Synthesis and characterization of the chromium(III) complexes of ethylene cross-bridged cyclam and cyclen ligands (2008)
Journal Article
Maples, D. L., Maples, R. D., Hoffert, W. A., Parsell, T. H., Asselt, A. V., Silversides, J. D., Archibald, S. J., & Hubin, T. J. (2009). Synthesis and characterization of the chromium(III) complexes of ethylene cross-bridged cyclam and cyclen ligands. Inorganica Chimica Acta, 362(6), 2084-2088. https://doi.org/10.1016/j.ica.2008.09.034

Dichloro(4,10-dimethyl-1,4,7,10-tetraazabicyclo[5.5.2] tetradecane) chromium(III) chloride, Dichloro(4,10-dibenzyl-1,4,7,10-tetraazabicyclo[ 5.5.2] tetradecane) chromium(III) chloride, and Dichloro(4,11-dimethyl- 1,4,8,11-tetraazabicyclo[6.6.2] hexad... Read More about Synthesis and characterization of the chromium(III) complexes of ethylene cross-bridged cyclam and cyclen ligands.

Characterization of RhoBTB-dependent Cul3 ubiquitin ligase complexes - Evidence for an autoregulatory mechanism (2008)
Journal Article
Schenková, K., Aspenström, P., Berthold, J., Ramos, S., Miura, Y., Furukawa, M., & Rivero-Crespo, F. (2008). Characterization of RhoBTB-dependent Cul3 ubiquitin ligase complexes - Evidence for an autoregulatory mechanism. Experimental Cell Research, 314(19), 3453-3465. https://doi.org/10.1016/j.yexcr.2008.09.005

RhoBTB proteins are atypical members of the Rho family of small GTPases. Two of the three RhoBTB proteins, RhoBTB1 and RhoBTB2, have been proposed as tumor suppressors and might function as adaptors of Cul3-dependent ubiquitin ligase complexes. Using... Read More about Characterization of RhoBTB-dependent Cul3 ubiquitin ligase complexes - Evidence for an autoregulatory mechanism.

Benz(2-heteroaryl)cyanoximes and their Tl(i) complexes: new room temperature blue emitters (2008)
Journal Article
Ilkun, O. T., Archibald, S. J., Barnes, C. L., Gerasimchuk, N., Biagioni, R., Silchenko, S., Gerasimchuk, O. A., & Nemykin, V. N. (2008). Benz(2-heteroaryl)cyanoximes and their Tl(i) complexes: new room temperature blue emitters. Dalton Transactions : an international journal of inorganic chemistry, 5715-5729. https://doi.org/10.1039/b803846e

A series of five 2-heteroarylcyanoximes such as: α-oximino-(2-benzimidazolyl)acetonitrile (HBIHCO), α-oximino-(N-methy-l-2-benzimidazolyl)acetonitrile (HBIMCO), α-oximino-(2-benzoxazolyl)acetonitrile (HBOCO), α-oximino-(2-benzothiazolyl)acetonitrile... Read More about Benz(2-heteroaryl)cyanoximes and their Tl(i) complexes: new room temperature blue emitters.

Tissue factor-containing microparticles released from mesangial cells in response to high glucose and AGE induce tube formation in microvascular cells (2008)
Journal Article
Ettelaie, C., Su, S., Li, C., & Collier, M. E. W. (2008). Tissue factor-containing microparticles released from mesangial cells in response to high glucose and AGE induce tube formation in microvascular cells. Microvascular Research, 76(3), 152-160. https://doi.org/10.1016/j.mvr.2008.07.007

Hyperglycaemia and the associated formation of advanced glycation end-products (AGE) have been implicated in the pathogenesis of diabetic vasculopathy. In addition to its role in coagulation, tissue factor (TF) is known to regulate vascular prolifera... Read More about Tissue factor-containing microparticles released from mesangial cells in response to high glucose and AGE induce tube formation in microvascular cells.

An internal polyadenylation signal substantially increases expression levels of lentivirus-delivered transgenes but has the potential to reduce viral titer in a promoter-dependent manner (2008)
Journal Article
Hager, S., Frame, F. M., Collins, A. T., Burns, J. E., & Maitland, N. J. (2008). An internal polyadenylation signal substantially increases expression levels of lentivirus-delivered transgenes but has the potential to reduce viral titer in a promoter-dependent manner. Human Gene Therapy, 19(8), 840-850. https://doi.org/10.1089/hum.2007.165

In lentiviral gene delivery systems, transgene expression cassettes are commonly cloned without a polyadenylation signal to prevent disruption of full-length lentiviral genomes on mRNA maturation in producer cells. The lack of the polyadenylation sig... Read More about An internal polyadenylation signal substantially increases expression levels of lentivirus-delivered transgenes but has the potential to reduce viral titer in a promoter-dependent manner.

The on-line synthesis of enzyme functionalized silica nanoparticles in a microfluidic reactor using polyethylenimine polymer and R5 peptide (2008)
Journal Article
He, P., Greenway, G., & Haswell, S. J. (2008). The on-line synthesis of enzyme functionalized silica nanoparticles in a microfluidic reactor using polyethylenimine polymer and R5 peptide. Nanotechnology, 19(31), 315603. https://doi.org/10.1088/0957-4484/19/31/315603

A simple microfluidic reactor system is described for the effective synthesis of enzyme functionalized nanoparticles which offers many advantages over batch reactions, including excellent enzyme efficiencies. Better control of the process parameters... Read More about The on-line synthesis of enzyme functionalized silica nanoparticles in a microfluidic reactor using polyethylenimine polymer and R5 peptide.

OC6. Endo180 function in metastatic prostate cancer bone lesions (2008)
Presentation / Conference Contribution
Kogianni, G., Eleftheriou, K., Waxman, J., Cobb, J. P., & Sturge, J. OC6. Endo180 function in metastatic prostate cancer bone lesions. Presented at VII International Conference on Cancer Induced Bone Disease, Edinburgh

Linking Ras to myosin function: RasGEF Q, a Dictyostelium exchange factor for RasB, affects myosin II functions (2008)
Journal Article
Mondal, S., Bakthavatsalam, D., Steimle, P., Gassen, B., Rivero, F., & Noegel, A. A. (2008). Linking Ras to myosin function: RasGEF Q, a Dictyostelium exchange factor for RasB, affects myosin II functions. Journal of Cell Biology, 181(5), 747-760. https://doi.org/10.1083/jcb.200710111

Ras guanine nucleotide exchange factor (GEF) Q, a nucleotide exchange factor from Dictyostelium discoideum, is a 143-kD protein containing RasGEF domains and a DEP domain. We show that RasGEF Q can bind to F-actin, has the potential to form complexes... Read More about Linking Ras to myosin function: RasGEF Q, a Dictyostelium exchange factor for RasB, affects myosin II functions.

Synthetic CD4+ T cell-targeted antigen-presenting cells elicit protective antitumor responses (2008)
Journal Article
Caserta, S., Alessi, P., Guarnerio, J., Basso, V., & Mondino, A. (2008). Synthetic CD4+ T cell-targeted antigen-presenting cells elicit protective antitumor responses. Cancer Research, 68(8), 3010-3018. https://doi.org/10.1158/0008-5472.can-07-5796

CD4 + helper T cells are critical for protective immune responses and yet suboptimally primed in response to tumors. Cell-based vaccination strategies are under evaluation in clinical trials but limited by the need to derive antigenpresenting cells... Read More about Synthetic CD4+ T cell-targeted antigen-presenting cells elicit protective antitumor responses.

Microparticle-associated vascular adhesion molecule-1 and tissue factor follow a circadian rhythm in healthy human subjects (2008)
Journal Article
Madden, L. A., Vince, R. V., Sandström, M. E., Taylor, L., McNaughton, L., & Laden, G. (2008). Microparticle-associated vascular adhesion molecule-1 and tissue factor follow a circadian rhythm in healthy human subjects. Thrombosis and haemostasis, 99(5), 909 - 915. https://doi.org/10.1160/th08-01-0030

An increased risk of death or severe injury due to late-morning thrombotic events is well established. Tissue factor (TF) is the initiator of the coagulation cascade, and endothelial stresses, coupled with production of pro-coagulant microparticles (... Read More about Microparticle-associated vascular adhesion molecule-1 and tissue factor follow a circadian rhythm in healthy human subjects.

Distinguishing Properties of Cells From the Myocardial Sleeves of the Pulmonary Veins: A Comparison of Normal and Abnormal Pacemakers (2008)
Journal Article
Jones, S. A., Yamamoto, M., Tellez, J. O., Billeter, R., Boyett, M. R., Honjo, H., & Lancaster, M. K. (2008). Distinguishing Properties of Cells From the Myocardial Sleeves of the Pulmonary Veins: A Comparison of Normal and Abnormal Pacemakers. Circulation. Arrhythmia and electrophysiology, 1(1), 39-48. https://doi.org/10.1161/CIRCEP.107.748467

BACKGROUND: A common source of arrhythmogenic spontaneous activity instigating atrial fibrillation is the myocardial tissue, or sleeves, at the base of the pulmonary veins. This study compared the properties of cells from the myocardial sleeves of th... Read More about Distinguishing Properties of Cells From the Myocardial Sleeves of the Pulmonary Veins: A Comparison of Normal and Abnormal Pacemakers.

Dictyostelium Sun-1 connects the centrosome to chromatin and ensures genome stability (2008)
Journal Article
Rivero, F., Xiong, H., Rivero-Crespo, F., Euteneuer, U., Mondal, S., Mana-Capelli, S., Larochelle, D., Vogel, A., Gassen, B., & Noegel, A. A. (2008). Dictyostelium Sun-1 connects the centrosome to chromatin and ensures genome stability. Traffic, 9(5), 708-724. https://doi.org/10.1111/j.1600-0854.2008.00721.x

The centrosome-nucleus attachment is a prerequisite for faithful chromosome segregation during mitosis. We addressed the function of the nuclear envelope (NE) protein Sun-1 in centrosome-nucleus connection and the maintenance of genome stability in D... Read More about Dictyostelium Sun-1 connects the centrosome to chromatin and ensures genome stability.

Investigation of the mechanisms of tissue factor-mediated evasion of tumour cells from cellular cytotoxicity (2008)
Journal Article
Li, C., Collier, M. E. W., Frentzou, G. A., Greenman, J., & Ettelaie, C. (2008). Investigation of the mechanisms of tissue factor-mediated evasion of tumour cells from cellular cytotoxicity. Cancer Immunology, Immunotherapy, 57(9), 1347-1355. https://doi.org/10.1007/s00262-008-0469-6

Aims We previously reported that overexpression of tissue factor (TF) protected HT29 tumour cells from cellular cytotoxicity through a mechanism requiring the presence of the cytoplasmic domain of TF. In this investigation the mechanism of TF-mediate... Read More about Investigation of the mechanisms of tissue factor-mediated evasion of tumour cells from cellular cytotoxicity.

Fluvastatin reduces oxidative damage in human vascular endothelial cells by upregulating Bcl-2 (2008)
Journal Article
Xu, S. Z., Zhong, W., Watson, N. M., Dickerson, E., Wake, J. D., Lindow, S. W., Newton, C. J., & Atkin, S. L. (2008). Fluvastatin reduces oxidative damage in human vascular endothelial cells by upregulating Bcl-2. Journal of thrombosis and haemostasis : JTH, 6(4), 692-700. https://doi.org/10.1111/j.1538-7836.2008.02913.x

Background: 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) have been widely used in clinical practise and their efficacy in reducing cardiovascular risk has been well described. Objectives: To investigate the effect of low doses... Read More about Fluvastatin reduces oxidative damage in human vascular endothelial cells by upregulating Bcl-2.