All Outputs (954)

N-linked glycosylation regulates human proteinase-activated receptor-1 cell surface expression and disarming via neutrophil proteinases and thermolysin (2011)
Journal Article
Xiao, Y. P., Morice, A. H., Compton, S. J., & Sadofsky, L. (2011). N-linked glycosylation regulates human proteinase-activated receptor-1 cell surface expression and disarming via neutrophil proteinases and thermolysin. Journal of Biological Chemistry, 286(26), 22991-23002. https://doi.org/10.1074/jbc.M110.204271

Proteinase-activated receptor 1 (PAR1) induces activation of platelet and vascular cells after proteolytic cleavage of its extracellular N terminus by thrombin. In pathological situations, other proteinases may be generated in the circulation and mig... Read More about N-linked glycosylation regulates human proteinase-activated receptor-1 cell surface expression and disarming via neutrophil proteinases and thermolysin.

Microsystems for personalized biomolecular diagnostics (2011)
Journal Article
Shaw, K. J., Birch, C., Hughes, E. M., Jakes, A. D., Greenman, J., & Haswell, S. J. (2011). Microsystems for personalized biomolecular diagnostics. Engineering in Life Sciences, 11(2), 121-132. https://doi.org/10.1002/elsc.201000175

The development of microfluidic methodology that can be used in conjunction with drug screening and biomolecular diagnostics offers a route to evidence-based personalized medical care. Ideally, all personal diagnostics are best carried out in a rapid... Read More about Microsystems for personalized biomolecular diagnostics.

Clinical evaluation of cellular immunotherapy in acute myeloid leukaemia (2011)
Journal Article
Smits, E. L., Lee, C., Hardwick, N., Brooks, S., Van Tendeloo, V. F., Orchard, K., & Guinn, B. A. (2011). Clinical evaluation of cellular immunotherapy in acute myeloid leukaemia. Cancer Immunology, Immunotherapy, 60(6), 757-769. https://doi.org/10.1007/s00262-011-1022-6

Immunotherapy is currently under active investigation as an adjuvant therapy to improve the overall survival of patients with acute myeloid leukaemia (AML) by eliminating residual leukaemic cells following standard therapy. The graft-versus-leukaemia... Read More about Clinical evaluation of cellular immunotherapy in acute myeloid leukaemia.

Flow focussing of particles and cells based on their intrinsic properties using a simple diamagnetic repulsion setup (2011)
Journal Article
Rodríguez-Villarreal, A. I., Tarn, M. D., Madden, L. A., Lutz, J. B., Greenman, J., Samitier, J., & Pamme, N. (2011). Flow focussing of particles and cells based on their intrinsic properties using a simple diamagnetic repulsion setup. Lab on a chip, 11(7), 1240-1248. https://doi.org/10.1039/c0lc00464b

The continuous flow focussing and manipulation of particles and cells are important factors in microfluidic applications for performing accurate and reproducible procedures downstream. Many particle focussing methods require complex setups or channel... Read More about Flow focussing of particles and cells based on their intrinsic properties using a simple diamagnetic repulsion setup.

Identification of methicillin-resistant Staphylococcus aureus-specific peptides for targeted photoantimicrobial chemotherapy (2011)
Journal Article
Vince, R. V., Madden, L. A., Alonso, C. M., Savoie, H., Boyle, R. W., Todman, M., Paget, T., & Greenman, J. (2011). Identification of methicillin-resistant Staphylococcus aureus-specific peptides for targeted photoantimicrobial chemotherapy. Photochemical & photobiological sciences : an international journal, 10(4), 515-522. https://doi.org/10.1039/c0pp00267d

The increasing prevalence of multi-drug resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), necessitates development of alternative modes of bacterial targeting which are not hindered by antibiotic resistance and minimise... Read More about Identification of methicillin-resistant Staphylococcus aureus-specific peptides for targeted photoantimicrobial chemotherapy.

Challenges in chelating positron emitting copper isotopes: tailored synthesis of unsymmetric chelators to form ultra stable complexes (2011)
Journal Article
Silversides, J. D., Smith, R., & Archibald, S. J. (2011). Challenges in chelating positron emitting copper isotopes: tailored synthesis of unsymmetric chelators to form ultra stable complexes. Dalton Transactions : an international journal of inorganic chemistry, 40(23), 6289-6297. https://doi.org/10.1039/c0dt01395a

The synthesis of chelators that form high stability complexes with copper(II) isotopes and do not suffer from transchelation in vivo has been a goal for many chemists. Such chelators will facilitate the exploitation of the Cu-64 isotope (t(1/2) = 12.... Read More about Challenges in chelating positron emitting copper isotopes: tailored synthesis of unsymmetric chelators to form ultra stable complexes.

Genome-wide transcriptomic analysis of the response to nitrogen limitation in Streptomyces coelicolor A3(2) (2011)
Journal Article
Lewis, R. A., Shahi, S. K., Laing, E., Bucca, G., Efthimiou, G., Bushell, M., & Smith, C. P. (2011). Genome-wide transcriptomic analysis of the response to nitrogen limitation in Streptomyces coelicolor A3(2). BMC research notes, 4(1), Article 78. https://doi.org/10.1186/1756-0500-4-78

Background: The present study represents a genome-wide transcriptomic analysis of the response of the model streptomycete Streptomyces coelicolor A3(2) M145 to fermentor culture in Modified Evans Media limited, respectively, for nitrogen, phosphate a... Read More about Genome-wide transcriptomic analysis of the response to nitrogen limitation in Streptomyces coelicolor A3(2).

A pilot study to investigate the role of the 26S proteasome in radiotherapy resistance and loco-regional recurrence following breast conserving therapy for early breast cancer (2011)
Journal Article
ELFadl, D., Hodgkinson, V. C., Long, E. D., Scaife, L., Drew, P. J., Lind, M. J., & Cawkwell, L. (2011). A pilot study to investigate the role of the 26S proteasome in radiotherapy resistance and loco-regional recurrence following breast conserving therapy for early breast cancer. The Breast : official journal of the European Society of Mastology, 20(4), 334-337. https://doi.org/10.1016/j.breast.2011.02.017

Breast conserving therapy is a currently accepted method for managing patients with early stage breast cancer. However, approximately 7% of patients may develop loco-regional tumour recurrence within 5 years. We previously reported that expression of... Read More about A pilot study to investigate the role of the 26S proteasome in radiotherapy resistance and loco-regional recurrence following breast conserving therapy for early breast cancer.

Preparation, structural characterization, and thermal ammonolysis of two novel dimeric transition silylamide complexes (2011)
Journal Article
Cheng, F., Hope, C. N., Archibald, S. J., Bradley, J. S., Clark, S., Francesconi, M. G., Kelly, S. M., Young, N. A., & Lefebvre, F. (2011). Preparation, structural characterization, and thermal ammonolysis of two novel dimeric transition silylamide complexes. International Journal of Applied Ceramic Technology, 8(2), 467-481. https://doi.org/10.1111/j.1744-7402.2009.02452.x

The preparation and molecular structures of two novel dimeric transition metal silylamide complexes {Li0.5Zr[NHSi(NMe2)3]1.5[NSi(NMe2)3]0.5[μ -NSi(NMe2)3]}2 and {Li0.5Hf[NHSi(NMe2)3]1.5[NSi(NMe2)3]0.5[μ-NSi(NMe2)3]}2 with a tetrahedral coordination e... Read More about Preparation, structural characterization, and thermal ammonolysis of two novel dimeric transition silylamide complexes.

Effect of the VWF promoter (GT) n repeat and single-nucleotide polymorphism c.-2527G>A on circulating von Willebrand factor levels under normal conditions (2011)
Journal Article
Hickson, N., Hampshire, D., Castaman, G., Eikenboom, J., Rodeghiero, F., Peake, I., & Goodeve, A. (2011). Effect of the VWF promoter (GT) n repeat and single-nucleotide polymorphism c.-2527G>A on circulating von Willebrand factor levels under normal conditions. Journal of thrombosis and haemostasis : JTH, 9(3), 603-605. https://doi.org/10.1111/j.1538-7836.2010.04161.x

Repeatedly identified differentially expressed proteins (RIDEPs) from antibody microarray proteomic analysis (2011)
Journal Article
Hodgkinson, V. C., ELFadl, D., Drew, P. J., Lind, M. J., & Cawkwell, L. (2011). Repeatedly identified differentially expressed proteins (RIDEPs) from antibody microarray proteomic analysis. Journal of Proteomics, 74(5), 698-703. https://doi.org/10.1016/j.jprot.2011.02.014

Antibody microarrays are powerful new tools in the field of comparative proteomics. The success of the biomarker discovery pipeline relies on the quality of data generated in the discovery phase and careful selection of proteins for the verification... Read More about Repeatedly identified differentially expressed proteins (RIDEPs) from antibody microarray proteomic analysis.

Regulation of the incorporation of tissue factor into microparticles by serine phosphorylation of the cytoplasmic domain of tissue factor (2011)
Journal Article
Collier, M. E. W., & Ettelaie, C. (2011). Regulation of the incorporation of tissue factor into microparticles by serine phosphorylation of the cytoplasmic domain of tissue factor. Journal of Biological Chemistry, 286(14), 11977-11984. https://doi.org/10.1074/jbc.m110.195214

The mechanisms that regulate the incorporation and release of tissue factors (TFs) into cell-derived microparticles are as yet unidentified. In this study, we have explored the regulation of TF release into microparticles by the phosphorylation of se... Read More about Regulation of the incorporation of tissue factor into microparticles by serine phosphorylation of the cytoplasmic domain of tissue factor.

Reversing microcrystalline tests—An analytical approach to recycling of microcrystals from drugs of abuse (2011)
Journal Article
Elie, L. E., Baron, M. G., Croxton, R. S., & Elie, M. P. (2011). Reversing microcrystalline tests—An analytical approach to recycling of microcrystals from drugs of abuse. Forensic Science International, 207(1-3), e55-e58. https://doi.org/10.1016/j.forsciint.2011.01.008

A combined analysis of microcrystalline tests followed by LC–MS or GC–MS analysis is described. Microcrystalline tests are shown to be non-destructive as addition products formed were easily dissociated after the application of an appropriate solvent... Read More about Reversing microcrystalline tests—An analytical approach to recycling of microcrystals from drugs of abuse.

Low molecular weight heparin suppresses tissue factor-mediated cancer cell invasion and migration in vitro (2011)
Journal Article
Ettelaie, C., Fountain, D., Collier, M. E. W., Beeby, E., Xiao, Y. P., & Maraveyas, A. (2011). Low molecular weight heparin suppresses tissue factor-mediated cancer cell invasion and migration in vitro. Experimental and Therapeutic Medicine, 2(2), 363-367. https://doi.org/10.3892/etm.2011.211

Elevated expression of tissue factor (TF) has been associated with an increased risk of thrombosis in the majority of cancers. Moreover, treatment of cancer patients with low molecular weight heparin (LMWH) appears to have beneficial effects that rea... Read More about Low molecular weight heparin suppresses tissue factor-mediated cancer cell invasion and migration in vitro.

The Value of Fieldwork in Life and Environmental Sciences in the Context of Higher Education: A Case Study in Learning About Biodiversity (2011)
Journal Article
Scott, G. W., Goulder, R., Wheeler, P., Scott, L. J., Tobin, M. L., & Marsham, S. (2012). The Value of Fieldwork in Life and Environmental Sciences in the Context of Higher Education: A Case Study in Learning About Biodiversity. Journal of Science Education and Technology, 21(1), 11-21. https://doi.org/10.1007/s10956-010-9276-x

Fieldwork is assumed by most practitioners to be an important if not essential component of a degree level education in the environmental sciences. However, there is strong evidence that as a result of a wide range of pressures (academic, financial a... Read More about The Value of Fieldwork in Life and Environmental Sciences in the Context of Higher Education: A Case Study in Learning About Biodiversity.

Axon and muscle spindle hyperplasia in the myostatin null mouse (2011)
Journal Article
Elashry, M. I., Otto, A., Matsakas, A., El-Morsy, S. E., Jones, L., Anderson, B., & Patel, K. (2011). Axon and muscle spindle hyperplasia in the myostatin null mouse. Journal of anatomy, 218(2), 173-184. https://doi.org/10.1111/j.1469-7580.2010.01327.x

Germline deletion of the myostatin gene results in hyperplasia and hypertrophy of the tension-generating (extrafusal) fibres in skeletal muscle. As this gene is expressed predominantly in myogenic tissues it offers an excellent model with which to in... Read More about Axon and muscle spindle hyperplasia in the myostatin null mouse.

Prostate cancer stem cells: do they have a basal or luminal phenotype? (2011)
Journal Article
Maitland, N. J., Frame, F. M., Polson, E. S., Lewis, J. L., & Collins, A. T. (2011). Prostate cancer stem cells: do they have a basal or luminal phenotype?. Hormones and Cancer, 2(1), 47-61. https://doi.org/10.1007/s12672-010-0058-y

The prostate is a luminal secretory tissue whose function is regulated by male sex hormones. Castration produces involution of the prostate to a reversible basal state, and as the majority of prostate cancers also have a luminal phenotype, drug-induc... Read More about Prostate cancer stem cells: do they have a basal or luminal phenotype?.

Encouraging use of community-based resources by bioscience students (2010)
Journal Article
Goulder, R., & Scott, G. W. (2010). Encouraging use of community-based resources by bioscience students. Bioscience education e-journal BEE-j, 16(1), 1-4. https://doi.org/10.3108/beej.16.c1

This communication reports how bioscience students are encouraged to benefit from city and regional community-based resources through use of a guidebook and student-managed learning. Positive outcomes of the module are that bioscience students take t... Read More about Encouraging use of community-based resources by bioscience students.

Altered Primary and Secondary Myogenesis in the Myostatin-Null Mouse (2010)
Journal Article
Matsakas, A., Otto, A., Elashry, M. I., Brown, S. C., & Patel, K. (2010). Altered Primary and Secondary Myogenesis in the Myostatin-Null Mouse. Rejuvenation Research, 13(6), 717-727. https://doi.org/10.1089/rej.2010.1065

Skeletal muscle fiber generation occurs principally in two myogenic phases: (1) Primary (embryonic) myogenesis when myoblasts proliferate and fuse to form primary myotubes and (2) secondary (fetal) myogenesis when successive waves of myoblasts fuse a... Read More about Altered Primary and Secondary Myogenesis in the Myostatin-Null Mouse.

Targeted epidermal growth factor receptor therapy in malignant pleural mesothelioma: where do we stand? (2010)
Journal Article
Agarwal, V., Lind, M. J., & Cawkwell, L. (2011). Targeted epidermal growth factor receptor therapy in malignant pleural mesothelioma: where do we stand?. Cancer Treatment Reviews, 37(7), 533-542. https://doi.org/10.1016/j.ctrv.2010.11.004

The median survival for patients with malignant pleural mesothelioma remains extremely poor and there is a need for the development of more effective treatment modalities. The epidermal growth factor receptor is frequently over-expressed in malignant... Read More about Targeted epidermal growth factor receptor therapy in malignant pleural mesothelioma: where do we stand?.