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Mechanisms underpinning the permanent muscle damage induced by snake venom metalloprotease (2019)
Journal Article
Williams, H. F., Mellows, B. A., Mitchell, R., Sfyri, P., Layfield, H. J., Salamah, M., Vaiyapuri, R., Collins-Hooper, H., Bicknell, A. B., Matsakas, A., Patel, K., & Vaiyapuri, S. (2019). Mechanisms underpinning the permanent muscle damage induced by snake venom metalloprotease. PLoS Neglected Tropical Diseases, 13(1), Article e0007041. https://doi.org/10.1371/journal.pntd.0007041

Snakebite is a major neglected tropical health issue that affects over 5 million people worldwide resulting in around 1.8 million envenomations and 100,000 deaths each year. Snakebite envenomation also causes innumerable morbidities specifically loss... Read More about Mechanisms underpinning the permanent muscle damage induced by snake venom metalloprotease.

Acetate as a model for aspartate-based CXCR4 chemokine receptor binding of cobalt and nickel complexes of cross-bridged tetraazamacrocycles (2019)
Journal Article
Cain, A. N., Carder Freeman, T. N., Roewe, K. D., Cockriel, D. L., Hasley, T. R., Maples, R. D., Allbritton, E. M. A., D'Huys, T., van Loy, T., Burke, B. P., Prior, T. J., Schols, D., Archibald, S. J., & Hubin, T. J. (2019). Acetate as a model for aspartate-based CXCR4 chemokine receptor binding of cobalt and nickel complexes of cross-bridged tetraazamacrocycles. Dalton Transactions : an international journal of inorganic chemistry, 48(8), 2785-2801. https://doi.org/10.1039/c8dt04728f

A number of disease states including WHIM syndrome, HIV infection and cancer have been linked to the chemokine receptor CXCR4. High-affinity CXCR4 antagonist transition metal complexes of configurationally restricted bis-tetraazamacrocyclic ligands h... Read More about Acetate as a model for aspartate-based CXCR4 chemokine receptor binding of cobalt and nickel complexes of cross-bridged tetraazamacrocycles.

Antigenic targets for the immunotherapy of acute myeloid leukaemia (2019)
Journal Article
Khan, G., Orchard, K., & Guinn, B. A. (2019). Antigenic targets for the immunotherapy of acute myeloid leukaemia. Journal of Clinical Medicine, 8(2), 134. https://doi.org/10.3390/jcm8020134

One of the most promising approaches to preventing relapse is the stimulation of the body’s own immune system to kill residual cancer cells after conventional therapy has destroyed the bulk of the tumour. In acute myeloid leukaemia (AML), the high fr... Read More about Antigenic targets for the immunotherapy of acute myeloid leukaemia.

Elevated local senescence in diabetic wound healing is linked to pathological repair via CXCR2. (2019)
Journal Article
Wilkinson, H. N., Clowes, C., Banyard, K. L., Matteuci, P., Mace, K., & Hardman, M. J. (2019). Elevated local senescence in diabetic wound healing is linked to pathological repair via CXCR2. Journal of Investigative Dermatology, 139(5), 1171-1181.e6. https://doi.org/10.1016/j.jid.2019.01.005

© 2019 The Authors Cellular senescence can be broadly defined as a stable, but essentially irreversible, loss of proliferative capacity. Historically, senescence has been described as a negative outcome of advanced cellular age. It is now clear, howe... Read More about Elevated local senescence in diabetic wound healing is linked to pathological repair via CXCR2..

Time intervals from first symptom to diagnosis for head and neck cancers: An analysis of linked patient reports and medical records from the UK (2019)
Journal Article
Allgar, V. L., Oliver, S. E., Chen, H., Oviasu, O., Johnson, M. J., & Macleod, U. (2019). Time intervals from first symptom to diagnosis for head and neck cancers: An analysis of linked patient reports and medical records from the UK. Cancer epidemiology, 59, 37-45. https://doi.org/10.1016/j.canep.2019.01.008

© 2019 Elsevier Ltd Background: England has significantly higher mortality risks due to Head and Neck Cancer (HNC) compared with other European countries. Early diagnosis is important as it is likely to increase early-stage diagnosis and improve surv... Read More about Time intervals from first symptom to diagnosis for head and neck cancers: An analysis of linked patient reports and medical records from the UK.

Metabolomic Screening of Embryos to Enhance Successful Selection and Transfer (2019)
Book Chapter
McKeegan, P. J., & Sturmey, R. G. (2019). Metabolomic Screening of Embryos to Enhance Successful Selection and Transfer. In G. Kovacs, A. Rutherford, & D. K. Gardner (Eds.), How to prepare the egg and embryo to maximize IVF success (295-304). Cambridge University Press. https://doi.org/10.1017/9781316756744.025

A key role of cellular metabolism is the provision of energy, in the form of adenosine triphosphate (ATP). In the case of the embryo, energy demand is dynamic and highly regulated to facilitate developmental milestones such as fertilization, cleavage... Read More about Metabolomic Screening of Embryos to Enhance Successful Selection and Transfer.

Alteration in endothelial permeability occurs in response to the activation of PAR2 by factor Xa but not directly by the TF-factor VIIa complex (2019)
Journal Article
Benelhaj, N. E., Maraveyas, A., Featherby, S., Collier, M. E., Johnson, M. J., & Ettelaie, C. (2019). Alteration in endothelial permeability occurs in response to the activation of PAR2 by factor Xa but not directly by the TF-factor VIIa complex. Thrombosis Research, 175, 13-20. https://doi.org/10.1016/j.thromres.2019.01.009

Alterations in the endothelial permeability occur in response to the activation of coagulation mechanisms in order to control clot formation. The activation of the protease activated receptors (PAR) can induce signals that regulate such cellular resp... Read More about Alteration in endothelial permeability occurs in response to the activation of PAR2 by factor Xa but not directly by the TF-factor VIIa complex.

Therapeutic targeting of the proinflammatory IL-6-JAK/STAT signalling pathways responsible for vascular restenosis in Type 2 diabetes mellitus (2019)
Journal Article
Moshapa, F. T., Riches-Suman, K., & Palmer, T. M. (2019). Therapeutic targeting of the proinflammatory IL-6-JAK/STAT signalling pathways responsible for vascular restenosis in Type 2 diabetes mellitus. Cardiology Research and Practice, 2019, Article ID 9846312. https://doi.org/10.1155/2019/9846312

Type 2 diabetes mellitus (T2DM) is increasing worldwide, and it is associated with increased risk of coronary artery disease (CAD). For T2DM patients, the main surgical intervention for CAD is autologous saphenous vein grafting. However, T2DM patient... Read More about Therapeutic targeting of the proinflammatory IL-6-JAK/STAT signalling pathways responsible for vascular restenosis in Type 2 diabetes mellitus.

Cell proliferation detected using [18F]FLT PET/CT as an early marker of abdominal aortic aneurysm (2019)
Journal Article
Gandhi, R., Cawthorne, C., Craggs, L. J., Wright, J. D., Domarkas, J., He, P., Koch-Paszkowski, J., Shires, M., Scarsbrook, A. F., Archibald, S. J., Tsoumpas, C., & Bailey, M. A. (2019). Cell proliferation detected using [18F]FLT PET/CT as an early marker of abdominal aortic aneurysm. Journal of Nuclear Cardiology, https://doi.org/10.1007/s12350-019-01946-y

© 2019, The Author(s). Background: Abdominal aortic aneurysm (AAA) is a focal aortic dilatation progressing towards rupture. Non-invasive AAA-associated cell proliferation biomarkers are not yet established. We investigated the feasibility of the cel... Read More about Cell proliferation detected using [18F]FLT PET/CT as an early marker of abdominal aortic aneurysm.

K2p3.1 protein is expressed as a transmural gradient across the rat left ventricular free wall (2018)
Journal Article
Jones, S. A., Walton, R. D., Morton, M., & Lancaster, M. K. (2019). K2p3.1 protein is expressed as a transmural gradient across the rat left ventricular free wall. Journal of Cardiovascular Electrophysiology, 30(3), 383-391. https://doi.org/10.1111/jce.13805

Introduction: K 2p 3.1, also known as TASK-1, is a twin-pore acid-sensitive repolarizing K + channel, responsible for a background potassium current that significantly contributes to setting the resting membrane potential of cardiac myocytes. Inhibit... Read More about K2p3.1 protein is expressed as a transmural gradient across the rat left ventricular free wall.

Genetic correlation between multiple myeloma and chronic lymphocytic leukaemia provides evidence for shared aetiology (2018)
Journal Article
Went, M., Sud, A., Speedy, H., Sunter, N. J., Försti, A., Law, P. J., Johnson, D. C., Mirabella, F., Holroyd, A., Li, N., Orlando, G., Weinhold, N., van Duin, M., Chen, B., Mitchell, J. S., Mansouri, L., Juliusson, G., Smedby, K. E., Jayne, S., Majid, A., …Houlston, R. S. (2019). Genetic correlation between multiple myeloma and chronic lymphocytic leukaemia provides evidence for shared aetiology. Blood Cancer Journal, 9(1), Article 1. https://doi.org/10.1038/s41408-018-0162-8

© 2018, The Author(s). The clustering of different types of B-cell malignancies in families raises the possibility of shared aetiology. To examine this, we performed cross-trait linkage disequilibrium (LD)-score regression of multiple myeloma (MM) a... Read More about Genetic correlation between multiple myeloma and chronic lymphocytic leukaemia provides evidence for shared aetiology.

A769662 inhibits insulin-stimulated akt activation in human macrovascular endothelial cells independent of AMP-activated protein kinase (2018)
Journal Article
Strembitska, A., Mancini, S. J., Gamwell, J. M., Palmer, T. M., Baillie, G. S., & Salt, I. P. (2018). A769662 inhibits insulin-stimulated akt activation in human macrovascular endothelial cells independent of AMP-activated protein kinase. International Journal of Molecular Sciences, 19(12), 3886. https://doi.org/10.3390/ijms19123886

Protein kinase B (Akt) is a key enzyme in the insulin signalling cascade, required for insulin-stimulated NO production in endothelial cells (ECs). Previous studies have suggested that AMP-activated protein kinase (AMPK) activation stimulates NO synt... Read More about A769662 inhibits insulin-stimulated akt activation in human macrovascular endothelial cells independent of AMP-activated protein kinase.

Can sit-to-stand muscle power explain the ability to perform functional tasks in adults with severe obesity? (2018)
Journal Article
Orange, S. T., Marshall, P., Madden, L. A., & Vince, R. V. (2019). Can sit-to-stand muscle power explain the ability to perform functional tasks in adults with severe obesity?. Journal of sports sciences, 37(11), 1227-1234. https://doi.org/10.1080/02640414.2018.1553500

This study examined the relationship between sit-to-stand (STS) power and physical function in adults with severe obesity. Thirty-eight adults (age: 44 ± 12 years; body mass index [BMI]: 45.2 ± 7.8 kg/m2) completed evaluations of STS power, strength... Read More about Can sit-to-stand muscle power explain the ability to perform functional tasks in adults with severe obesity?.

Visualizing kinetically robust CoIII4L6 assemblies in Vivo: SPECT imaging of the encapsulated [99mTc]TcO4- Anion (2018)
Journal Article
Burke, B. P., Grantham, W., Burke, M. J., Nichol, G. S., Roberts, D., Renard, I., Hargreaves, R., Cawthorne, C., Archibald, S. J., & Lusby, P. J. (2018). Visualizing kinetically robust CoIII4L6 assemblies in Vivo: SPECT imaging of the encapsulated [99mTc]TcO4- Anion. Journal of the American Chemical Society, 140(49), 16877-16881. https://doi.org/10.1021/jacs.8b09582

© 2018 American Chemical Society. Noncovalent encapsulation is an attractive approach for modifying the efficacy and physiochemical properties of both therapeutic and diagnostic species. Abiotic self-assembled constructs have shown promise, yet many... Read More about Visualizing kinetically robust CoIII4L6 assemblies in Vivo: SPECT imaging of the encapsulated [99mTc]TcO4- Anion.

Effect of high glucose on human alveolar macrophage phenotype and phagocytosis of mycobacteria (2018)
Journal Article
Vance, J., Santos, A., Sadofsky, L., Morice, A., & Cervantes, J. (2019). Effect of high glucose on human alveolar macrophage phenotype and phagocytosis of mycobacteria. Lung, 197(1), 89–94. https://doi.org/10.1007/s00408-018-0181-z

Purpose Diabetes mellitus (DBM) reduces immunological activity and increases susceptibility to various infections, including tuberculosis (TB). Human alveolar macrophage (hAM) functions are altered in DBM. Methods To mimic hyperglycemic conditions i... Read More about Effect of high glucose on human alveolar macrophage phenotype and phagocytosis of mycobacteria.

Platelet releasate promotes skeletal myogenesis by increasing muscle stem cell commitment to differentiation and accelerates muscle regeneration following acute injury (2018)
Journal Article
Scully, D., Sfyri, P., Verpoorten, S., Papadopoulos, P., Muñoz-Turrillas, M. C., Mitchell, R., Aburima, A., Patel, K., Gutiérrez, L., Naseem, K. M., & Matsakas, A. (2019). Platelet releasate promotes skeletal myogenesis by increasing muscle stem cell commitment to differentiation and accelerates muscle regeneration following acute injury. Acta Physiologica, 225(3), Article e13207. https://doi.org/10.1111/apha.13207

Aim The use of platelets as biomaterials has gained intense research interest. However, the mechanisms regarding platelet‐mediated skeletal myogenesis remain to be established. The aim of this study was to determine the role of platelet releasate in... Read More about Platelet releasate promotes skeletal myogenesis by increasing muscle stem cell commitment to differentiation and accelerates muscle regeneration following acute injury.

Effects of acute insulin-induced hypoglycaemia on endothelial microparticles in adults with and without type 2 diabetes (2018)
Journal Article
Al-Qaissi, A., Papageorgiou, M., Deshmukh, H., Madden, L. A., Rigby, A., Kilpatrick, E. S., Atkin, S. L., & Sathyapalan, T. (2019). Effects of acute insulin-induced hypoglycaemia on endothelial microparticles in adults with and without type 2 diabetes. Diabetes, Obesity and Metabolism, 21(3), 533-540. https://doi.org/10.1111/dom.13548

Aims Endothelial microparticles (EMPs) are novel surrogate markers of endothelial injury and dysfunction that may be differentially produced in response to acute insulin‐induced hypoglycaemia in adults with and without type 2 diabetes.

Agreement between blood draw techniques for assessing platelet activation by flow cytometry (2018)
Journal Article
Welch, E. L., Crooks, M. G., & Hart, S. P. (2019). Agreement between blood draw techniques for assessing platelet activation by flow cytometry. Platelets, 30(4), 530-534. https://doi.org/10.1080/09537104.2018.1535705

It is widely believed that assays of platelet activation are susceptible to preanalytical variables related to blood draw technique. We assessed platelet activation by whole blood flow cytometry and investigated the effects of: (1) drawing blood into... Read More about Agreement between blood draw techniques for assessing platelet activation by flow cytometry.

Inhibiting arginine methylation as a tool to investigate cross-talk with methylation and acetylation post-translational modifications in a glioblastoma cell line (2018)
Journal Article
Samuel, S. F., Marsden, A. J., Deepak, S., Rivero, F., Greenman, J., & Beltran-Alvarez, P. (2018). Inhibiting arginine methylation as a tool to investigate cross-talk with methylation and acetylation post-translational modifications in a glioblastoma cell line. Proteomes, 6(4), Article 44. https://doi.org/10.3390/proteomes6040044

Glioblastomas (GBM) are the most common grade 4 brain tumours; patients have very poor prognosis with an average survival of 15 months after diagnosis. Novel research lines have begun to explore aberrant protein arginine methylation (ArgMe) as a poss... Read More about Inhibiting arginine methylation as a tool to investigate cross-talk with methylation and acetylation post-translational modifications in a glioblastoma cell line.